(99 nodes) Positive regulation of double-strand break repair network (Astatotilapia calliptera)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSACLP00000032745	DDE_3 domain-containing protein. (209 aa)
	ENSACLP00000033394	Uncharacterized protein. (95 aa)
	ENSACLP00000033624	Bromo domain-containing protein. (257 aa)
	ENSACLP00000033646	Uncharacterized protein. (94 aa)
	ENSACLP00000033700	HTH_Tnp_Tc3_2 domain-containing protein. (124 aa)
	ENSACLP00000034173	Uncharacterized protein. (104 aa)
	pias4	Protein inhibitor of activated STAT, 4a. (507 aa)
	parp3	Poly [ADP-ribose] polymerase. (532 aa)
	LOC113020311	SET domain-containing protein. (2049 aa)
	ENSACLP00000035424	Uncharacterized protein. (160 aa)
	ENSACLP00000035801	Uncharacterized protein. (157 aa)
	bcl7a	BAF chromatin remodeling complex subunit BCL7A. (199 aa)
	ENSACLP00000037930	Uncharacterized protein. (339 aa)
	LOC113032036	Spire-type actin nucleation factor 1b. (868 aa)
	ENSACLP00000038280	Uncharacterized protein. (80 aa)
	ENSACLP00000038980	Uncharacterized protein. (291 aa)
	yeats4	YEATS domain containing 4. (226 aa)
	actr2	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (394 aa)
	ENSACLP00000039041	Uncharacterized protein. (294 aa)
	ENSACLP00000040085	Uncharacterized protein. (167 aa)
	ENSACLP00000040104	HTH_Tnp_Tc3_2 domain-containing protein. (150 aa)
	ENSACLP00000040457	Uncharacterized protein. (282 aa)
	ENSACLP00000040559	Uncharacterized protein. (333 aa)
	ENSACLP00000040884	annotation not available (275 aa)
	ENSACLP00000041419	Uncharacterized protein. (313 aa)
	ENSACLP00000041280	Uncharacterized protein. (214 aa)
	ENSACLP00000000488	Uncharacterized protein. (81 aa)
	ENSACLP00000000972	HTH_Tnp_Tc3_2 domain-containing protein. (197 aa)
	ENSACLP00000001381	Uncharacterized protein. (342 aa)
	kmt5b	Lysine methyltransferase 5B. (910 aa)
	ENSACLP00000002055	Structural maintenance of chromosomes flexible hinge domain containing 1. (1782 aa)
	ENSACLP00000002185	Uncharacterized protein. (339 aa)
	ENSACLP00000002677	LEDGF domain-containing protein. (309 aa)
	ENSACLP00000002696	PWWP domain-containing protein. (110 aa)
	ENSACLP00000002706	Fumarate hydratase. (508 aa)
	ENSACLP00000002986	RING-type domain-containing protein. (206 aa)
	LOC113010023	Enhancer of polycomb homolog. (838 aa)
	arid2	AT rich interactive domain 2 (ARID, RFX-like). (1702 aa)
	sirt6	Sirtuin 6. (351 aa)
	dtx3	Zgc:66440. (369 aa)
	timeless	Timeless circadian clock. (1249 aa)
	ENSACLP00000006278	Uncharacterized protein. (309 aa)
	ENSACLP00000008127	Uncharacterized protein. (127 aa)
	ENSACLP00000008430	Uncharacterized protein. (117 aa)
	ENSACLP00000008529	Uncharacterized protein. (90 aa)
	ENSACLP00000008753	Uncharacterized protein. (436 aa)
	spire2	Spire-type actin nucleation factor 2. (782 aa)
	ENSACLP00000008938	Uncharacterized protein. (339 aa)
	LOC113034173	Uncharacterized protein. (237 aa)
	ENSACLP00000009352	SMC5-SMC6 complex localization factor 1. (723 aa)
	ercc6	Excision repair cross-complementation group 6. (1439 aa)
	ENSACLP00000012492	Uncharacterized protein. (276 aa)
	ENSACLP00000012888	Uncharacterized protein. (322 aa)
	ENSACLP00000013395	Uncharacterized protein. (185 aa)
	LOC113034961	Uncharacterized protein. (1420 aa)
	ENSACLP00000015558	Helicase, POLQ like. (821 aa)
	LOC113029328	Enhancer of polycomb homolog. (845 aa)
	ENSACLP00000016050	Uncharacterized protein. (322 aa)
	mrgbp	MRG/MORF4L binding protein. (220 aa)
	pnkp	Polynucleotide kinase 3'-phosphatase. (602 aa)
	ENSACLP00000017396	Uncharacterized protein. (181 aa)
	ENSACLP00000018376	Uncharacterized protein. (134 aa)
	ENSACLP00000018517	Uncharacterized protein. (190 aa)
	ENSACLP00000019769	Uncharacterized protein. (337 aa)
	vps72	Vacuolar protein sorting 72 homolog a. (366 aa)
	LOC113018933	Zgc:101810; Belongs to the actin family. (394 aa)
	ENSACLP00000021856	Uncharacterized protein. (284 aa)
	ENSACLP00000022849	Uncharacterized protein. (578 aa)
	ENSACLP00000022919	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (999 aa)
	ENSACLP00000022921	Uncharacterized protein. (323 aa)
	ENSACLP00000022953	Pogo transposable element derived with ZNF domain b. (1877 aa)
	ENSACLP00000023083	Transformation/transcription domain-associated protein; Belongs to the PI3/PI4-kinase family. (2569 aa)
	ENSACLP00000023092	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4053 aa)
	MGMT	O-6-methylguanine-DNA methyltransferase. (198 aa)
	ENSACLP00000024574	Uncharacterized protein. (318 aa)
	ENSACLP00000024944	DDE_3 domain-containing protein. (338 aa)
	ENSACLP00000024950	Uncharacterized protein. (81 aa)
	LOC113033185	Si:dkey-3h3.3. (427 aa)
	spire1	Spire-type actin nucleation factor 1a. (799 aa)
	ENSACLP00000025911	Uncharacterized protein. (202 aa)
	LOC113009745	Fork-head domain-containing protein. (757 aa)
	ENSACLP00000026572	Uncharacterized protein. (319 aa)
	ENSACLP00000026809	Uncharacterized protein. (1222 aa)
	ENSACLP00000026867	Uncharacterized protein. (93 aa)
	mms19	MMS19 homolog, cytosolic iron-sulfur assembly component. (1031 aa)
	ENSACLP00000026990	Uncharacterized protein. (335 aa)
	wdr48	WD repeat domain 48b. (685 aa)
	spidr	Uncharacterized protein. (935 aa)
	ENSACLP00000027673	Uncharacterized protein. (76 aa)
	ENSACLP00000027709	Forkhead box M1. (581 aa)
	FOXM1	Forkhead box M1. (495 aa)
	wrap53	WD repeat containing, antisense to TP53. (545 aa)
	ENSACLP00000028323	DDE_3 domain-containing protein. (338 aa)
	ENSACLP00000028424	Uncharacterized protein. (79 aa)
	actl6a	Actin-like 6A; Belongs to the actin family. (432 aa)
	ENSACLP00000029756	Uncharacterized protein. (347 aa)
	dmap1	DNA methyltransferase 1 associated protein 1. (481 aa)
	ENSACLP00000030800	Uncharacterized protein. (118 aa)
	LOC113022928	SET domain and mariner transposase fusion gene. (316 aa)

Your Current Organism:

Astatotilapia calliptera

NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSACLP00000002677	ENSACLP00000002696	ENSACLP00000002677	ENSACLP00000002696	LEDGF domain-containing protein.	PWWP domain-containing protein.	0.880
ENSACLP00000002696	ENSACLP00000002677	ENSACLP00000002696	ENSACLP00000002677	PWWP domain-containing protein.	LEDGF domain-containing protein.	0.880
ENSACLP00000002986	LOC113033185	ENSACLP00000002986	ENSACLP00000025315	RING-type domain-containing protein.	Si:dkey-3h3.3.	0.824
ENSACLP00000002986	dtx3	ENSACLP00000002986	ENSACLP00000004877	RING-type domain-containing protein.	Zgc:66440.	0.825
ENSACLP00000008753	ENSACLP00000015558	ENSACLP00000008753	ENSACLP00000015558	Uncharacterized protein.	Helicase, POLQ like.	0.571
ENSACLP00000008753	wdr48	ENSACLP00000008753	ENSACLP00000027363	Uncharacterized protein.	WD repeat domain 48b.	0.745
ENSACLP00000009352	ENSACLP00000023092	ENSACLP00000009352	ENSACLP00000023092	SMC5-SMC6 complex localization factor 1.	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	0.414
ENSACLP00000009352	sirt6	ENSACLP00000009352	ENSACLP00000004612	SMC5-SMC6 complex localization factor 1.	Sirtuin 6.	0.438
ENSACLP00000009352	timeless	ENSACLP00000009352	ENSACLP00000005627	SMC5-SMC6 complex localization factor 1.	Timeless circadian clock.	0.670
ENSACLP00000015558	ENSACLP00000008753	ENSACLP00000015558	ENSACLP00000008753	Helicase, POLQ like.	Uncharacterized protein.	0.571
ENSACLP00000015558	ENSACLP00000022919	ENSACLP00000015558	ENSACLP00000022919	Helicase, POLQ like.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.645
ENSACLP00000015558	parp3	ENSACLP00000015558	ENSACLP00000034876	Helicase, POLQ like.	Poly [ADP-ribose] polymerase.	0.594
ENSACLP00000022849	ENSACLP00000023083	ENSACLP00000022849	ENSACLP00000023083	Uncharacterized protein.	Transformation/transcription domain-associated protein; Belongs to the PI3/PI4-kinase family.	0.923
ENSACLP00000022849	ENSACLP00000023092	ENSACLP00000022849	ENSACLP00000023092	Uncharacterized protein.	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	0.495
ENSACLP00000022849	ENSACLP00000028424	ENSACLP00000022849	ENSACLP00000028424	Uncharacterized protein.	Uncharacterized protein.	0.807
ENSACLP00000022849	ENSACLP00000033624	ENSACLP00000022849	ENSACLP00000033624	Uncharacterized protein.	Bromo domain-containing protein.	0.807
ENSACLP00000022849	ENSACLP00000033646	ENSACLP00000022849	ENSACLP00000033646	Uncharacterized protein.	Uncharacterized protein.	0.807
ENSACLP00000022849	LOC113010023	ENSACLP00000022849	ENSACLP00000003026	Uncharacterized protein.	Enhancer of polycomb homolog.	0.949
ENSACLP00000022849	LOC113018933	ENSACLP00000022849	ENSACLP00000020934	Uncharacterized protein.	Zgc:101810; Belongs to the actin family.	0.557
ENSACLP00000022849	LOC113029328	ENSACLP00000022849	ENSACLP00000015687	Uncharacterized protein.	Enhancer of polycomb homolog.	0.949