(59 nodes) ATPase, AAA-type, core network (Astatotilapia calliptera)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC113014266	Bromo domain-containing protein. (1295 aa)
	psmc4	Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (417 aa)
	psmc2	Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
	fign	Fidgetin; Belongs to the AAA ATPase family. (752 aa)
	SPATA5	Spermatogenesis associated 5. (898 aa)
	FIGNL2	Fidgetin like 2. (688 aa)
	ENSACLP00000005459	Uncharacterized protein; Belongs to the AAA ATPase family. (501 aa)
	trip13	Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (423 aa)
	vps4a	Vacuolar protein sorting 4 homolog A; Belongs to the AAA ATPase family. (451 aa)
	chtf18	AAA domain-containing protein. (922 aa)
	LOC113023517	AAA domain-containing protein. (771 aa)
	nvl	Nuclear VCP like. (864 aa)
	ENSACLP00000009814	AAA domain-containing protein. (866 aa)
	LOC113021414	N-ethylmaleimide-sensitive factor a. (754 aa)
	CLPB	ClpB homolog, mitochondrial AAA ATPase chaperonin. (676 aa)
	rfc5	Replication factor C (activator 1) 5. (335 aa)
	lonp2	Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import; Belongs to the peptidase S16 family. ECO:0000256\|PROSITE-. (842 aa)
	VPS4B	Vacuolar protein sorting 4 homolog B; Belongs to the AAA ATPase family. (485 aa)
	ENSACLP00000032193	ATPase family AAA domain containing 2. (1320 aa)
	ATAD3A	ATPase family AAA domain containing 3A. (665 aa)
	orc1	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (899 aa)
	psmc6	Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (389 aa)
	LOC113033882	ATPase family AAA domain containing 1a; Belongs to the AAA ATPase family. (404 aa)
	psmc1	Proteasome 26S subunit, ATPase 1b; Belongs to the AAA ATPase family. (440 aa)
	ENSACLP00000030049	Zgc:153738. (739 aa)
	ENSACLP00000035605	Zgc:136908; Belongs to the AAA ATPase family. (721 aa)
	LOC113028093	N-ethylmaleimide-sensitive factor b. (746 aa)
	spg7	SPG7 matrix AAA peptidase subunit, paraplegin. (808 aa)
	KATNAL2	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays. (380 aa)
	ENSACLP00000038050	AAA domain-containing protein. (767 aa)
	atad2b	ATPase family AAA domain containing 2B. (1452 aa)
	KATNA1-2	Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. (346 aa)
	rfc4	Replication factor C (activator 1) 4. (357 aa)
	ENSACLP00000001994	ATPase family AAA domain containing 5a. (1510 aa)
	ENSACLP00000003469	Si:ch1073-174d20.2; Belongs to the AAA ATPase family. (666 aa)
	vcp	Valosin containing protein; Belongs to the AAA ATPase family. (806 aa)
	LOC113007497	BC1 (ubiquinol-cytochrome c reductase) synthesis-like; Belongs to the AAA ATPase family. (420 aa)
	wrnip1	WRN helicase interacting protein 1. (603 aa)
	ENSACLP00000030020	Uncharacterized protein; Belongs to the AAA ATPase family. (692 aa)
	lonp1	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family. (1002 aa)
	pex6	Peroxisomal biogenesis factor 6. (1044 aa)
	pex1	Peroxisomal biogenesis factor 1. (1247 aa)
	ENSACLP00000029011	Uncharacterized protein; Belongs to the AAA ATPase family. (499 aa)
	fignl1	Fidgetin-like 1; Belongs to the AAA ATPase family. (637 aa)
	KATNA1	Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. (513 aa)
	ENSACLP00000026893	Neuron navigator 3. (2275 aa)
	spata5l1	Spermatogenesis associated 5-like 1. (782 aa)
	cdc6	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (602 aa)
	afg3l2	AFG3-like AAA ATPase 2. (800 aa)
	atad1	ATPase family AAA domain containing 1b; Belongs to the AAA ATPase family. (364 aa)
	LOC113010874	YME1-like 1b. (719 aa)
	rfc1	Replication factor C subunit 1. (1161 aa)
	LOC113016205	Uncharacterized protein; Belongs to the AAA ATPase family. (435 aa)
	LOC113029275	YME1-like 1a. (732 aa)
	psmc3	Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (476 aa)
	LOC113018080	AAA domain-containing protein; Belongs to the AAA ATPase family. (345 aa)
	clpx	Caseinolytic mitochondrial matrix peptidase chaperone subunit b. (624 aa)
	rfc2	Replication factor C (activator 1) 2. (356 aa)
	psmc5	Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (448 aa)

Your Current Organism:

Astatotilapia calliptera

NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLPB	ENSACLP00000003469	ENSACLP00000011388	ENSACLP00000003469	ClpB homolog, mitochondrial AAA ATPase chaperonin.	Si:ch1073-174d20.2; Belongs to the AAA ATPase family.	0.453
CLPB	KATNAL2	ENSACLP00000011388	ENSACLP00000037605	ClpB homolog, mitochondrial AAA ATPase chaperonin.	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	0.554
CLPB	LOC113007497	ENSACLP00000011388	ENSACLP00000004356	ClpB homolog, mitochondrial AAA ATPase chaperonin.	BC1 (ubiquinol-cytochrome c reductase) synthesis-like; Belongs to the AAA ATPase family.	0.453
CLPB	LOC113010874	ENSACLP00000011388	ENSACLP00000022626	ClpB homolog, mitochondrial AAA ATPase chaperonin.	YME1-like 1b.	0.495
CLPB	LOC113023517	ENSACLP00000011388	ENSACLP00000009031	ClpB homolog, mitochondrial AAA ATPase chaperonin.	AAA domain-containing protein.	0.453
CLPB	LOC113029275	ENSACLP00000011388	ENSACLP00000011960	ClpB homolog, mitochondrial AAA ATPase chaperonin.	YME1-like 1a.	0.495
CLPB	afg3l2	ENSACLP00000011388	ENSACLP00000024123	ClpB homolog, mitochondrial AAA ATPase chaperonin.	AFG3-like AAA ATPase 2.	0.453
CLPB	clpx	ENSACLP00000011388	ENSACLP00000015539	ClpB homolog, mitochondrial AAA ATPase chaperonin.	Caseinolytic mitochondrial matrix peptidase chaperone subunit b.	0.742
CLPB	lonp1	ENSACLP00000011388	ENSACLP00000029952	ClpB homolog, mitochondrial AAA ATPase chaperonin.	Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family.	0.929
CLPB	lonp2	ENSACLP00000011388	ENSACLP00000033550	ClpB homolog, mitochondrial AAA ATPase chaperonin.	Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import; Belongs to the peptidase S16 family. ECO:0000256\|PROSITE-.	0.929
CLPB	psmc3	ENSACLP00000011388	ENSACLP00000013269	ClpB homolog, mitochondrial AAA ATPase chaperonin.	Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family.	0.408
CLPB	spg7	ENSACLP00000011388	ENSACLP00000037314	ClpB homolog, mitochondrial AAA ATPase chaperonin.	SPG7 matrix AAA peptidase subunit, paraplegin.	0.453
ENSACLP00000001994	ENSACLP00000005459	ENSACLP00000001994	ENSACLP00000005459	ATPase family AAA domain containing 5a.	Uncharacterized protein; Belongs to the AAA ATPase family.	0.467
ENSACLP00000001994	ENSACLP00000029011	ENSACLP00000001994	ENSACLP00000029011	ATPase family AAA domain containing 5a.	Uncharacterized protein; Belongs to the AAA ATPase family.	0.467
ENSACLP00000001994	ENSACLP00000030020	ENSACLP00000001994	ENSACLP00000030020	ATPase family AAA domain containing 5a.	Uncharacterized protein; Belongs to the AAA ATPase family.	0.467
ENSACLP00000001994	ENSACLP00000030049	ENSACLP00000001994	ENSACLP00000030049	ATPase family AAA domain containing 5a.	Zgc:153738.	0.409
ENSACLP00000001994	ENSACLP00000035605	ENSACLP00000001994	ENSACLP00000035605	ATPase family AAA domain containing 5a.	Zgc:136908; Belongs to the AAA ATPase family.	0.566
ENSACLP00000001994	ENSACLP00000038050	ENSACLP00000001994	ENSACLP00000038050	ATPase family AAA domain containing 5a.	AAA domain-containing protein.	0.448
ENSACLP00000001994	FIGNL2	ENSACLP00000001994	ENSACLP00000004727	ATPase family AAA domain containing 5a.	Fidgetin like 2.	0.467
ENSACLP00000001994	KATNAL2	ENSACLP00000001994	ENSACLP00000037605	ATPase family AAA domain containing 5a.	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	0.456