(145 nodes) WD40 repeat, conserved site network (Astatotilapia calliptera)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC113009944	Fizzy/cell division cycle 20 related 1b. (531 aa)
	eif3i	Eukaryotic translation initiation factor 3 subunit I; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (334 aa)
	WDSUB1	WD repeat, sterile alpha motif and U-box domain containing 1. (485 aa)
	pex7	Peroxisomal biogenesis factor 7. (307 aa)
	ENSACLP00000009777	WDFY family member 4. (309 aa)
	WDR1	WD repeat domain 1. (470 aa)
	wdr37	WD repeat domain 37. (522 aa)
	rrp9	Ribosomal RNA processing 9, U3 small nucleolar RNA binding protein. (482 aa)
	LOC113017146	Uncharacterized protein. (720 aa)
	LOC113026198	POC1 centriolar protein B. (525 aa)
	dcaf12	DDB1 and CUL4 associated factor 12. (483 aa)
	LLGL1	LLGL scribble cell polarity complex component 1. (1068 aa)
	ENSACLP00000017518	WD repeat domain 24. (819 aa)
	ENSACLP00000017156	WD repeat domain 90. (1616 aa)
	eed	Embryonic ectoderm development. (443 aa)
	LOC113016769	PWP2 small subunit processome component. (935 aa)
	ciao1	Probable cytosolic iron-sulfur protein assembly protein CIAO1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Belongs to the WD repeat CIA1 family. (330 aa)
	LOC113010599	Transducin (beta)-like 1 X-linked receptor 1b. (512 aa)
	wdr83	WD repeat domain containing 83. (317 aa)
	pak1ip1	PAK1 interacting protein 1. (359 aa)
	LOC113030479	Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration; Belongs to the WD repeat LIS1/nudF family. (410 aa)
	ENSACLP00000011033	Kinesin family member 21B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1652 aa)
	wdr36	WD repeat domain 36. (889 aa)
	ENSACLP00000011575	Receptor for activated C kinase 1. (233 aa)
	LOC113036056	Receptor for activated C kinase 1. (317 aa)
	gnb5	Guanine nucleotide binding protein (G protein), beta 5a. (361 aa)
	atg16l1	ATG16 autophagy related 16-like 1 (S. cerevisiae). (604 aa)
	wdr89	WD repeat domain 89. (378 aa)
	traf7	TNF receptor-associated factor 7. (725 aa)
	wdhd1	WD repeat and HMG-box DNA binding protein 1. (1134 aa)
	prpf19	Pre-mRNA processing factor 19. (505 aa)
	ENSACLP00000014943	UTP15 small subunit processome component. (571 aa)
	ENSACLP00000015189	WD_REPEATS_REGION domain-containing protein. (617 aa)
	brwd3	Bromodomain and WD repeat domain containing 3. (1794 aa)
	LOC113036715	F-box and WD repeat domain containing 11b. (527 aa)
	plrg1	Pleiotropic regulator 1. (513 aa)
	nup43	Nucleoporin 43. (372 aa)
	TBL1XR1	Transducin beta like 1 X-linked receptor 1. (515 aa)
	pwp1	PWP1 homolog, endonuclein. (487 aa)
	wdr5	WD repeat domain 5. (333 aa)
	ENSACLP00000038704	F-box and WD repeat domain containing 7. (773 aa)
	tbl3	Transducin (beta)-like 3. (927 aa)
	LOC113020740	Coronin; Belongs to the WD repeat coronin family. (930 aa)
	cstf1	Cleavage stimulation factor, 3' pre-RNA, subunit 1. (431 aa)
	coro1c	Coronin; Belongs to the WD repeat coronin family. (1131 aa)
	LOC113006854	Uncharacterized protein. (887 aa)
	phip	Pleckstrin homology domain interacting protein. (1835 aa)
	dcaf13	Ddb1 and cul4 associated factor 13. (495 aa)
	wdr12	Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (421 aa)
	gnb3	Guanine nucleotide binding protein (G protein), beta polypeptide 3a. (340 aa)
	KATNB1	Katanin p80 WD40 repeat-containing subunit B1; Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. (640 aa)
	gemin5	Gem (nuclear organelle) associated protein 5. (1491 aa)
	LOC113027513	Retinoblastoma binding protein 4, like. (427 aa)
	ENSACLP00000000815	WD40 repeat domain 95. (669 aa)
	LOC113016048	TLE family member 2, transcriptional corepressor a. (776 aa)
	LOC113017016	TLE family member 2, transcriptional corepressor b. (769 aa)
	wdr47	WD repeat domain 47a. (916 aa)
	ENSACLP00000002207	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1. (4874 aa)
	fbxw9	F-box and WD repeat domain containing 9. (576 aa)
	wdr75	WD repeat domain 75. (837 aa)
	ENSACLP00000003275	Bromodomain and WD repeat domain containing 1. (1628 aa)
	FZR1	Fizzy/cell division cycle 20 related 1a. (496 aa)
	ENSACLP00000003704	Striatin, calmodulin binding protein. (779 aa)
	EML6	EMAP like 6. (1958 aa)
	WDR7	WD repeat domain 7. (1497 aa)
	ENSACLP00000004083	WD repeat and FYVE domain containing 3. (3521 aa)
	gtf3c2	General transcription factor IIIC, polypeptide 2, beta. (948 aa)
	LOC113018688	Coronin; Belongs to the WD repeat coronin family. (525 aa)
	WDR49	WD repeat domain 49. (879 aa)
	LOC113011815	Retinoblastoma binding protein 4. (424 aa)
	LOC113014472	WD_REPEATS_REGION domain-containing protein. (426 aa)
	ENSACLP00000006837	WD_REPEATS_REGION domain-containing protein. (529 aa)
	LOC113028313	SEC31 homolog B, COPII coat complex component. (1219 aa)
	cop1	COP1 E3 ubiquitin ligase. (715 aa)
	ENSACLP00000007109	WD repeat domain 17. (1243 aa)
	copa	Coatomer subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. (1222 aa)
	ENSACLP00000007302	SREBF chaperone. (1271 aa)
	chaf1b	Chromatin assembly factor 1, subunit B. (600 aa)
	coro6	Coronin; Belongs to the WD repeat coronin family. (514 aa)
	KIF21A	Kinesin family member 21A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1589 aa)
	LOC113007872	Transducin beta like 1 X-linked. (533 aa)
	daw1	Dynein assembly factor with WDR repeat domains 1. (415 aa)
	BOP1	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (645 aa)
	wdr59	WD repeat domain 59. (991 aa)
	cfap52	Cilia and flagella associated protein 52. (620 aa)
	DCAF7	DDB1 and CUL4 associated factor 7. (342 aa)
	wdr61	WD repeat domain 61. (305 aa)
	ENSACLP00000036564	WD_REPEATS_REGION domain-containing protein. (159 aa)
	STRN	Striatin. (779 aa)
	EML5	EMAP like 5. (1959 aa)
	LOC113020313	Coronin; Belongs to the WD repeat coronin family. (456 aa)
	ENSACLP00000034749	WD_REPEATS_REGION domain-containing protein. (132 aa)
	dtl	Denticleless E3 ubiquitin protein ligase homolog (Drosophila). (661 aa)
	ENSACLP00000034615	Lysosomal trafficking regulator. (3728 aa)
	wsb2	WD repeat and SOCS box containing 2. (450 aa)
	WDR77	WD repeat domain 77. (337 aa)
	LOC113024317	Coronin; Belongs to the WD repeat coronin family. (525 aa)
	nedd1	NEDD1 gamma-tubulin ring complex targeting factor. (658 aa)
	wsb1	WD repeat and SOCS box containing 1. (427 aa)
	nle1	Notchless homolog 1 (Drosophila). (535 aa)
	ambra1	Autophagy/beclin-1 regulator 1b. (1358 aa)
	lrwd1	Leucine-rich repeats and WD repeat domain containing 1. (743 aa)
	ENSACLP00000031815	Kinesin family member 21A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1488 aa)
	grwd1	Glutamate-rich WD repeat containing 1. (481 aa)
	tbl2	Transducin (beta)-like 2. (441 aa)
	wdfy2	WD repeat and FYVE domain containing 2. (400 aa)
	pafah1b1	Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration; Belongs to the WD repeat LIS1/nudF family. (410 aa)
	ENSACLP00000030223	NACHT and WD repeat domain containing 1. (1364 aa)
	WDR31	WD repeat domain 31. (327 aa)
	wdr18	WD repeat domain 18. (431 aa)
	fbxw2	F-box and WD repeat domain containing 2. (454 aa)
	rae1	Ribonucleic acid export 1. (368 aa)
	gnb4	Guanine nucleotide binding protein (G protein), beta polypeptide 4b. (345 aa)
	snrnp40	Small nuclear ribonucleoprotein 40 (U5). (347 aa)
	prpf4	PRP4 pre-mRNA processing factor 4 homolog (yeast). (510 aa)
	LOC113024232	SMU1 DNA replication regulator and spliceosomal factor b. (510 aa)
	wdr48	WD repeat domain 48b. (685 aa)
	taf5	TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (750 aa)
	LOC113033510	Uncharacterized protein. (772 aa)
	POC1A	POC1 centriolar protein A. (472 aa)
	ENSACLP00000026279	Striatin, calmodulin binding protein 4. (750 aa)
	TLE4	Uncharacterized protein. (783 aa)
	LOC113013015	Guanine nucleotide binding protein (G protein), beta polypeptide 1a. (340 aa)
	cdc40	Cell division cycle 40 homolog (S. cerevisiae). (581 aa)
	wdr3	WD repeat domain 3. (941 aa)
	strn3	Striatin, calmodulin binding protein 3. (706 aa)
	wdr53	WD repeat domain 53. (383 aa)
	nup37	Nucleoporin 37. (323 aa)
	ENSACLP00000023991	TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor. (622 aa)
	ENSACLP00000023989	Coronin; Belongs to the WD repeat coronin family. (1247 aa)
	mlst8	MTOR associated protein, LST8 homolog (S. cerevisiae). (342 aa)
	thoc6	THO complex 6. (334 aa)
	ercc8	Excision repair cross-complementation group 8. (424 aa)
	ENSACLP00000022915	Coronin; Belongs to the WD repeat coronin family. (334 aa)
	LOC113015060	Guanine nucleotide binding protein (G protein), beta polypeptide 3b. (342 aa)
	TLE3	TLE family member 3, transcriptional corepressor. (801 aa)
	SMU1	SMU1 DNA replication regulator and spliceosomal factor. (540 aa)
	ENSACLP00000021729	TLE family member 3, transcriptional corepressor. (747 aa)
	GNB5	Guanine nucleotide binding protein (G protein), beta 5b. (353 aa)
	coro2b	Coronin; Belongs to the WD repeat coronin family. (481 aa)
	ddb2	Damage-specific DNA binding protein 2. (543 aa)
	wdfy1	WD repeat and FYVE domain containing 1. (410 aa)
	ENSACLP00000020699	WD_REPEATS_REGION domain-containing protein. (460 aa)
	LOC113022298	Guanine nucleotide binding protein (G protein), beta polypeptide 1b. (340 aa)
	ENSACLP00000020432	Guanine nucleotide binding protein (G protein), beta polypeptide 2. (327 aa)

Your Current Organism:

Astatotilapia calliptera

NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BOP1	EML5	ENSACLP00000008725	ENSACLP00000035505	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	EMAP like 5.	0.535
BOP1	EML6	ENSACLP00000008725	ENSACLP00000003837	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	EMAP like 6.	0.535
BOP1	ENSACLP00000003275	ENSACLP00000008725	ENSACLP00000003275	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Bromodomain and WD repeat domain containing 1.	0.535
BOP1	ENSACLP00000006837	ENSACLP00000008725	ENSACLP00000006837	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	WD_REPEATS_REGION domain-containing protein.	0.535
BOP1	ENSACLP00000007109	ENSACLP00000008725	ENSACLP00000007109	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	WD repeat domain 17.	0.837
BOP1	ENSACLP00000014943	ENSACLP00000008725	ENSACLP00000014943	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	UTP15 small subunit processome component.	0.730
BOP1	ENSACLP00000023991	ENSACLP00000008725	ENSACLP00000023991	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor.	0.535
BOP1	ENSACLP00000030223	ENSACLP00000008725	ENSACLP00000030223	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	NACHT and WD repeat domain containing 1.	0.535
BOP1	FZR1	ENSACLP00000008725	ENSACLP00000003391	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Fizzy/cell division cycle 20 related 1a.	0.584
BOP1	LOC113007872	ENSACLP00000008725	ENSACLP00000008617	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Transducin beta like 1 X-linked.	0.535
BOP1	LOC113009944	ENSACLP00000008725	ENSACLP00000020143	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Fizzy/cell division cycle 20 related 1b.	0.584
BOP1	LOC113010599	ENSACLP00000008725	ENSACLP00000015703	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Transducin (beta)-like 1 X-linked receptor 1b.	0.535
BOP1	LOC113016769	ENSACLP00000008725	ENSACLP00000016831	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	PWP2 small subunit processome component.	0.905
BOP1	TBL1XR1	ENSACLP00000008725	ENSACLP00000040294	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Transducin beta like 1 X-linked receptor 1.	0.535
BOP1	WDR77	ENSACLP00000008725	ENSACLP00000034205	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	WD repeat domain 77.	0.539
BOP1	brwd3	ENSACLP00000008725	ENSACLP00000015269	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Bromodomain and WD repeat domain containing 3.	0.535
BOP1	dcaf13	ENSACLP00000008725	ENSACLP00000037216	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Ddb1 and cul4 associated factor 13.	0.697
BOP1	grwd1	ENSACLP00000008725	ENSACLP00000031707	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Glutamate-rich WD repeat containing 1.	0.939
BOP1	nle1	ENSACLP00000008725	ENSACLP00000032882	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Notchless homolog 1 (Drosophila).	0.926
BOP1	pak1ip1	ENSACLP00000008725	ENSACLP00000010182	Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	PAK1 interacting protein 1.	0.741