32 items (Astatotilapia calliptera) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	apaf1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1258 aa)
	ENSACLP00000030351	Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (334 aa)
	casp9	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (423 aa)
	LOC113007482	Transmembrane protein 198a. (390 aa)
	casp7	Caspase 7, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (312 aa)
	LOC113015928	Transmembrane protein 198b. (364 aa)
	LOC113029596	Zgc:153993. (274 aa)
	septin5	Septin 5a; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (376 aa)
	LOC113031667	PYD and CARD domain containing. (199 aa)
	apip	Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway. May play a role in apoptosis. (245 aa)
	LOC113007820	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (121 aa)
	LOC113025186	Septin 5b; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (369 aa)
	LOC113021014	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (394 aa)
	LOC113015255	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (113 aa)
	LOC113015033	Uncharacterized protein. (203 aa)
	LOC113014732	Uncharacterized protein. (463 aa)
	LOC113036932	Diablo, IAP-binding mitochondrial protein a. (237 aa)
	LOC113036951	Diablo, IAP-binding mitochondrial protein a. (264 aa)
	mapk1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa)
	LOC113022614	DUF4203 domain-containing protein. (340 aa)
	gsdme	Gasdermin Eb. (476 aa)
	bax	Uncharacterized protein. (205 aa)
	ENSACLP00000006475	Uncharacterized protein. (165 aa)
	ENSACLP00000007057	Uncharacterized protein. (412 aa)
	ENSACLP00000008297	DUF4062 domain-containing protein. (131 aa)
	ENSACLP00000009370	Uncharacterized protein. (281 aa)
	ENSACLP00000010624	Septin 4a; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (495 aa)
	LOC113035255-2	Cytochrome c. (104 aa)
	LOC113035255	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
	aven	Apoptosis, caspase activation inhibitor. (328 aa)
	ENSACLP00000036974	X-linked inhibitor of apoptosis. (427 aa)
	FILIP1L	Filamin A interacting protein 1 like. (1241 aa)

Your Current Organism:

Astatotilapia calliptera

NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSACLP00000006475	ENSACLP00000009370	ENSACLP00000006475	ENSACLP00000009370	Uncharacterized protein.	Uncharacterized protein.	0.428
ENSACLP00000006475	LOC113007820	ENSACLP00000006475	ENSACLP00000012331	Uncharacterized protein.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.894
ENSACLP00000006475	LOC113015033	ENSACLP00000006475	ENSACLP00000001206	Uncharacterized protein.	Uncharacterized protein.	0.606
ENSACLP00000006475	LOC113015255	ENSACLP00000006475	ENSACLP00000001199	Uncharacterized protein.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.894
ENSACLP00000006475	LOC113029596	ENSACLP00000006475	ENSACLP00000000007	Uncharacterized protein.	Zgc:153993.	0.967
ENSACLP00000006475	LOC113035255	ENSACLP00000006475	ENSACLP00000040361	Uncharacterized protein.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.877
ENSACLP00000006475	LOC113035255-2	ENSACLP00000006475	ENSACLP00000040499	Uncharacterized protein.	Cytochrome c.	0.877
ENSACLP00000006475	LOC113036932	ENSACLP00000006475	ENSACLP00000004116	Uncharacterized protein.	Diablo, IAP-binding mitochondrial protein a.	0.428
ENSACLP00000006475	LOC113036951	ENSACLP00000006475	ENSACLP00000005018	Uncharacterized protein.	Diablo, IAP-binding mitochondrial protein a.	0.428
ENSACLP00000006475	apaf1	ENSACLP00000006475	ENSACLP00000032714	Uncharacterized protein.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.741
ENSACLP00000006475	casp9	ENSACLP00000006475	ENSACLP00000026306	Uncharacterized protein.	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.492
ENSACLP00000007057	LOC113031667	ENSACLP00000007057	ENSACLP00000016475	Uncharacterized protein.	PYD and CARD domain containing.	0.544
ENSACLP00000008297	ENSACLP00000009370	ENSACLP00000008297	ENSACLP00000009370	DUF4062 domain-containing protein.	Uncharacterized protein.	0.631
ENSACLP00000008297	ENSACLP00000036974	ENSACLP00000008297	ENSACLP00000036974	DUF4062 domain-containing protein.	X-linked inhibitor of apoptosis.	0.715
ENSACLP00000008297	LOC113007482	ENSACLP00000008297	ENSACLP00000026196	DUF4062 domain-containing protein.	Transmembrane protein 198a.	0.472
ENSACLP00000008297	LOC113007820	ENSACLP00000008297	ENSACLP00000012331	DUF4062 domain-containing protein.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.966
ENSACLP00000008297	LOC113015033	ENSACLP00000008297	ENSACLP00000001206	DUF4062 domain-containing protein.	Uncharacterized protein.	0.906
ENSACLP00000008297	LOC113015255	ENSACLP00000008297	ENSACLP00000001199	DUF4062 domain-containing protein.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.966
ENSACLP00000008297	LOC113015928	ENSACLP00000008297	ENSACLP00000018778	DUF4062 domain-containing protein.	Transmembrane protein 198b.	0.472
ENSACLP00000008297	LOC113021014	ENSACLP00000008297	ENSACLP00000011537	DUF4062 domain-containing protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.437