(23 nodes) PI3K events in ERBB2 signaling network (Astatotilapia calliptera)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSACLP00000014200	Receptor protein-tyrosine kinase. (1407 aa)
	LOC113008803	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	ENSACLP00000041264	EGF-like domain-containing protein. (703 aa)
	LOC113034337	EGF-like domain-containing protein. (199 aa)
	LOC113013517	Erb-b2 receptor tyrosine kinase 3b. (1460 aa)
	ENSACLP00000015318	Receptor protein-tyrosine kinase. (970 aa)
	ENSACLP00000015432	Epidermal growth factor. (985 aa)
	LOC113010568	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	LOC113018242	PH domain-containing protein. (781 aa)
	LOC113019391	Neuregulin 3b. (778 aa)
	LOC113025599	Betacellulin, epidermal growth factor family member. (194 aa)
	LOC113019652	Zgc:158659; Belongs to the PI3/PI4-kinase family. (1070 aa)
	LOC113010022	Receptor protein-tyrosine kinase. (1206 aa)
	LOC113029559	Receptor protein-tyrosine kinase. (1175 aa)
	grb2	Growth factor receptor-bound protein 2b. (217 aa)
	LOC113007667	Receptor protein-tyrosine kinase. (1374 aa)
	nrg4	EGF-like domain-containing protein. (109 aa)
	LOC113025288	Neuregulin 1. (626 aa)
	LOC113030566	Neuregulin 2a. (709 aa)
	LOC113036403	Crystallin, beta B1, like 3; Belongs to the beta/gamma-crystallin family. (209 aa)
	LOC113033325	Neuregulin 2b. (712 aa)
	ENSACLP00000036859	Uncharacterized protein. (386 aa)
	gab1	GRB2-associated binding protein 1. (746 aa)

Your Current Organism:

Astatotilapia calliptera

NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSACLP00000014200	ENSACLP00000015318	ENSACLP00000014200	ENSACLP00000015318	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.876
ENSACLP00000014200	ENSACLP00000015432	ENSACLP00000014200	ENSACLP00000015432	Receptor protein-tyrosine kinase.	Epidermal growth factor.	0.962
ENSACLP00000014200	ENSACLP00000041264	ENSACLP00000014200	ENSACLP00000041264	Receptor protein-tyrosine kinase.	EGF-like domain-containing protein.	0.871
ENSACLP00000014200	LOC113007667	ENSACLP00000014200	ENSACLP00000027774	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.828
ENSACLP00000014200	LOC113008803	ENSACLP00000014200	ENSACLP00000038993	Receptor protein-tyrosine kinase.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.882
ENSACLP00000014200	LOC113010568	ENSACLP00000014200	ENSACLP00000015873	Receptor protein-tyrosine kinase.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.897
ENSACLP00000014200	LOC113018242	ENSACLP00000014200	ENSACLP00000017806	Receptor protein-tyrosine kinase.	PH domain-containing protein.	0.743
ENSACLP00000014200	LOC113019391	ENSACLP00000014200	ENSACLP00000019874	Receptor protein-tyrosine kinase.	Neuregulin 3b.	0.891
ENSACLP00000014200	LOC113019652	ENSACLP00000014200	ENSACLP00000020128	Receptor protein-tyrosine kinase.	Zgc:158659; Belongs to the PI3/PI4-kinase family.	0.882
ENSACLP00000014200	LOC113025288	ENSACLP00000014200	ENSACLP00000028641	Receptor protein-tyrosine kinase.	Neuregulin 1.	0.934
ENSACLP00000014200	LOC113025599	ENSACLP00000014200	ENSACLP00000003724	Receptor protein-tyrosine kinase.	Betacellulin, epidermal growth factor family member.	0.914
ENSACLP00000014200	LOC113030566	ENSACLP00000014200	ENSACLP00000028700	Receptor protein-tyrosine kinase.	Neuregulin 2a.	0.945
ENSACLP00000014200	LOC113033325	ENSACLP00000014200	ENSACLP00000033200	Receptor protein-tyrosine kinase.	Neuregulin 2b.	0.945
ENSACLP00000014200	LOC113034337	ENSACLP00000014200	ENSACLP00000012774	Receptor protein-tyrosine kinase.	EGF-like domain-containing protein.	0.948
ENSACLP00000014200	LOC113036403	ENSACLP00000014200	ENSACLP00000031604	Receptor protein-tyrosine kinase.	Crystallin, beta B1, like 3; Belongs to the beta/gamma-crystallin family.	0.441
ENSACLP00000014200	gab1	ENSACLP00000014200	ENSACLP00000037247	Receptor protein-tyrosine kinase.	GRB2-associated binding protein 1.	0.743
ENSACLP00000014200	grb2	ENSACLP00000014200	ENSACLP00000027361	Receptor protein-tyrosine kinase.	Growth factor receptor-bound protein 2b.	0.971
ENSACLP00000014200	nrg4	ENSACLP00000014200	ENSACLP00000028215	Receptor protein-tyrosine kinase.	EGF-like domain-containing protein.	0.903
ENSACLP00000015318	ENSACLP00000014200	ENSACLP00000015318	ENSACLP00000014200	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.876
ENSACLP00000015318	ENSACLP00000015432	ENSACLP00000015318	ENSACLP00000015432	Receptor protein-tyrosine kinase.	Epidermal growth factor.	0.975