(51 nodes) RHOH GTPase cycle network (Astatotilapia calliptera)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	mtr	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1269 aa)
	vcp	Valosin containing protein; Belongs to the AAA ATPase family. (806 aa)
	LOC113012314	Non-specific serine/threonine protein kinase. (697 aa)
	PAK2	Non-specific serine/threonine protein kinase. (513 aa)
	VAMP3	Vesicle associated membrane protein 3. (103 aa)
	nsfl1c	NSFL1 (p97) cofactor (p47). (373 aa)
	ENSACLP00000010400	NIPSNAP domain-containing protein. (291 aa)
	CSK	Tyrosine-protein kinase. (451 aa)
	lamtor1	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (158 aa)
	LOC113021027	Rho GDP dissociation inhibitor (GDI) alpha. (206 aa)
	ENSACLP00000014270	Transmembrane protein 59. (315 aa)
	ARHGDIA	Uncharacterized protein. (203 aa)
	osbpl11	Oxysterol-binding protein; Belongs to the OSBP family. (718 aa)
	ENSACLP00000016464	Tyrosine-protein kinase. (610 aa)
	LOC113021483	Uncharacterized protein. (834 aa)
	cav1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (181 aa)
	LOC113021157	Rho GDP dissociation inhibitor (GDI) gamma. (222 aa)
	SPATA5	Spermatogenesis associated 5. (898 aa)
	pak2	Non-specific serine/threonine protein kinase. (529 aa)
	LOC113011423	Transferrin receptor 1a. (771 aa)
	ENSACLP00000021794	Transferrin receptor 1a. (744 aa)
	ENSACLP00000021806	Uncharacterized protein. (98 aa)
	uaca	Uveal autoantigen with coiled-coil domains and ankyrin repeats b. (1377 aa)
	ENSACLP00000023365	Non-specific serine/threonine protein kinase. (662 aa)
	pak1	Non-specific serine/threonine protein kinase. (591 aa)
	rock1	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1386 aa)
	spata5l1	Spermatogenesis associated 5-like 1. (782 aa)
	PAK3	Non-specific serine/threonine protein kinase. (575 aa)
	pak4	Non-specific serine/threonine protein kinase. (660 aa)
	slc1a5	Solute carrier family 1 member 5. (527 aa)
	fam91a1	Family with sequence similarity 91 member A1. (833 aa)
	CSK-2	Tyrosine-protein kinase. (450 aa)
	LOC113022863	RAB7a, member RAS oncogene family. (207 aa)
	LOC113023765	Junction plakoglobin a. (728 aa)
	ENSACLP00000028421	Ral GTPase activating protein, alpha subunit 2 (catalytic). (2011 aa)
	lck	Tyrosine-protein kinase. (501 aa)
	dbt	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (497 aa)
	ENSACLP00000030140	Nipsnap homolog 2. (325 aa)
	wdr11	WD repeat domain 11. (1242 aa)
	PAK6	Non-specific serine/threonine protein kinase. (647 aa)
	LOC113034100	Nipsnap homolog 1 (C. elegans). (267 aa)
	ENSACLP00000034847	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (150 aa)
	LOC113021701	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (165 aa)
	ENSACLP00000035605	Zgc:136908; Belongs to the AAA ATPase family. (721 aa)
	LOC113022527	Uncharacterized protein. (210 aa)
	LOC113022528	RAB7A, member RAS oncogene family. (207 aa)
	ENSACLP00000036642	Ral GTPase activating protein, alpha subunit 1 (catalytic). (2198 aa)
	ENSACLP00000036795	Ral GTPase activating protein, alpha subunit 1 (catalytic). (709 aa)
	rock2	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1396 aa)
	pak5	Non-specific serine/threonine protein kinase. (782 aa)
	VANGL1	Vang-like protein. (536 aa)

Your Current Organism:

Astatotilapia calliptera

NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSK	ENSACLP00000010400	ENSACLP00000010630	ENSACLP00000010400	Tyrosine-protein kinase.	NIPSNAP domain-containing protein.	0.519
CSK	ENSACLP00000014270	ENSACLP00000010630	ENSACLP00000014270	Tyrosine-protein kinase.	Transmembrane protein 59.	0.598
CSK	ENSACLP00000016464	ENSACLP00000010630	ENSACLP00000016464	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.566
CSK	ENSACLP00000023365	ENSACLP00000010630	ENSACLP00000023365	Tyrosine-protein kinase.	Non-specific serine/threonine protein kinase.	0.495
CSK	ENSACLP00000030140	ENSACLP00000010630	ENSACLP00000030140	Tyrosine-protein kinase.	Nipsnap homolog 2.	0.519
CSK	ENSACLP00000034847	ENSACLP00000010630	ENSACLP00000034847	Tyrosine-protein kinase.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.668
CSK	ENSACLP00000035605	ENSACLP00000010630	ENSACLP00000035605	Tyrosine-protein kinase.	Zgc:136908; Belongs to the AAA ATPase family.	0.602
CSK	LOC113012314	ENSACLP00000010630	ENSACLP00000005049	Tyrosine-protein kinase.	Non-specific serine/threonine protein kinase.	0.495
CSK	LOC113021483	ENSACLP00000010630	ENSACLP00000017221	Tyrosine-protein kinase.	Uncharacterized protein.	0.604
CSK	LOC113021701	ENSACLP00000010630	ENSACLP00000034855	Tyrosine-protein kinase.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.646
CSK	LOC113022527	ENSACLP00000010630	ENSACLP00000036096	Tyrosine-protein kinase.	Uncharacterized protein.	0.417
CSK	LOC113022528	ENSACLP00000010630	ENSACLP00000036175	Tyrosine-protein kinase.	RAB7A, member RAS oncogene family.	0.417
CSK	LOC113022863	ENSACLP00000010630	ENSACLP00000027744	Tyrosine-protein kinase.	RAB7a, member RAS oncogene family.	0.417
CSK	LOC113023765	ENSACLP00000010630	ENSACLP00000028091	Tyrosine-protein kinase.	Junction plakoglobin a.	0.604
CSK	LOC113034100	ENSACLP00000010630	ENSACLP00000034064	Tyrosine-protein kinase.	Nipsnap homolog 1 (C. elegans).	0.519
CSK	PAK2	ENSACLP00000010630	ENSACLP00000008028	Tyrosine-protein kinase.	Non-specific serine/threonine protein kinase.	0.564
CSK	PAK3	ENSACLP00000010630	ENSACLP00000024991	Tyrosine-protein kinase.	Non-specific serine/threonine protein kinase.	0.545
CSK	PAK6	ENSACLP00000010630	ENSACLP00000033442	Tyrosine-protein kinase.	Non-specific serine/threonine protein kinase.	0.495
CSK	SPATA5	ENSACLP00000010630	ENSACLP00000020878	Tyrosine-protein kinase.	Spermatogenesis associated 5.	0.602
CSK	VAMP3	ENSACLP00000010630	ENSACLP00000009650	Tyrosine-protein kinase.	Vesicle associated membrane protein 3.	0.520