(108 nodes) PPAR signaling pathway network (Astatotilapia calliptera)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSACLP00000013429	Solute carrier family 27 member 6. (670 aa)
	LOC113007633	Uncharacterized protein; Belongs to the FGGY kinase family. (540 aa)
	ENSACLP00000000796	Ankyrin repeat domain 24. (1140 aa)
	ENSACLP00000002933	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (472 aa)
	ENSACLP00000002959	PLAT domain-containing protein. (505 aa)
	LOC113032455	Retinoid x receptor, beta b. (444 aa)
	LOC113027051	Carnitine palmitoyltransferase 1Ab (liver); Belongs to the carnitine/choline acetyltransferase family. (777 aa)
	ppard	Peroxisome proliferator-activated receptor delta b. (509 aa)
	acaa1	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (429 aa)
	ENSACLP00000003820	Uncharacterized protein. (83 aa)
	ILK	Integrin linked kinase. (452 aa)
	LOC113018666	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (158 aa)
	LOC113007866	Cytochrome P450, family 27, subfamily A, polypeptide 7; Belongs to the cytochrome P450 family. (535 aa)
	acox1	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (661 aa)
	LOC113014969	Apolipoprotein A-IV a. (250 aa)
	FABP7	Fatty acid binding protein 7; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
	LOC113036968	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (306 aa)
	ppara	Peroxisome proliferator-activated receptor alpha a. (476 aa)
	nr1i2	Nuclear receptor subfamily 1, group I, member 2. (441 aa)
	SCD	Stearoyl-CoA desaturase; Belongs to the fatty acid desaturase type 1 family. (350 aa)
	LOC113032471	Fatty acid binding protein 11b; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (134 aa)
	LOC113019272	Uncharacterized protein; Belongs to the carnitine/choline acetyltransferase family. (785 aa)
	acadm	Acyl-CoA dehydrogenase medium chain. (424 aa)
	ENSACLP00000009605	Ubiquitin B. (723 aa)
	LOC113007799	Diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein). (90 aa)
	ENSACLP00000010701	Phosphoenolpyruvate carboxykinase 1 (soluble). (620 aa)
	FABP6	Fatty acid binding protein 6. (151 aa)
	ENSACLP00000010807	Carn_acyltransf domain-containing protein. (85 aa)
	angptl4	Angiopoietin-like 4. (466 aa)
	ENSACLP00000011803	Carnitine palmitoyltransferase 1Cb; Belongs to the carnitine/choline acetyltransferase family. (786 aa)
	LOC113034296	Acyl-CoA synthetase long chain family member 2. (712 aa)
	ENSACLP00000013213	Si:ch211-255i3.4. (73 aa)
	DBI	ACB domain-containing protein. (93 aa)
	ENSACLP00000040535	Sorbin and SH3 domain containing 2a. (1459 aa)
	LOC113010910	Acyl-CoA synthetase long chain family member 3b. (711 aa)
	cpt2	Carnitine palmitoyltransferase 2; Belongs to the carnitine/choline acetyltransferase family. (670 aa)
	ENSACLP00000039118	Retinoid X receptor, alpha a. (501 aa)
	PPARA	Peroxisome proliferator-activated receptor alpha b. (501 aa)
	LOC113026910	Carnitine palmitoyltransferase 1B (muscle); Belongs to the carnitine/choline acetyltransferase family. (786 aa)
	acsl5	Acyl-CoA synthetase long chain family member 5. (695 aa)
	acsl4	Acyl-CoA synthetase long chain family member 4a. (712 aa)
	LOC113016027	Uncharacterized protein. (465 aa)
	ENSACLP00000036571	Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (313 aa)
	me1	Malic enzyme. (650 aa)
	LOC113023871	AMP-binding domain-containing protein. (646 aa)
	LOC113011007	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (513 aa)
	LOC113015604-2	Uncharacterized protein; Belongs to the FGGY kinase family. (567 aa)
	LOC113031029	Uncharacterized protein. (452 aa)
	plin2	Perilipin; Belongs to the perilipin family. (434 aa)
	LOC113014375	Fatty acid binding protein 10b, liver basic. (169 aa)
	LOC113015822	Perilipin; Belongs to the perilipin family. (437 aa)
	slc27a4	Solute carrier family 27 member 4. (655 aa)
	slc27a1	Solute carrier family 27 member 1a. (648 aa)
	fabp6	Fatty acid binding protein 6, ileal (gastrotropin). (127 aa)
	ENSACLP00000030567	Si:dkey-91i10.3; Belongs to the cytochrome P450 family. (610 aa)
	ENSACLP00000030202	Acyl-CoA synthetase long chain family member 1b. (682 aa)
	armc2	Armadillo repeat containing 2. (823 aa)
	acsl1	Acyl-CoA synthetase long chain family member 1a. (720 aa)
	LOC113034409	AMP-binding domain-containing protein. (750 aa)
	ENSACLP00000029463	Fatty acid binding protein 2, intestinal; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (107 aa)
	ENSACLP00000029236	Sorbin and SH3 domain containing 1. (936 aa)
	RXRB	Retinoid X receptor beta. (470 aa)
	UFC1	Ubiquitin-fold modifier conjugating enzyme 1. (98 aa)
	cd36	CD36 molecule (thrombospondin receptor); Belongs to the CD36 family. (468 aa)
	ENSACLP00000028248	Phosphoenolpyruvate carboxykinase 2 (mitochondrial). (646 aa)
	LOC113014489	Fatty acid binding protein 3, muscle and heart; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (172 aa)
	LOC113020177	Uncharacterized protein. (662 aa)
	ENSACLP00000028142	Solute carrier family 27 member 2a. (384 aa)
	ENSACLP00000028103	Solute carrier family 27 member 2a. (615 aa)
	LOC113025280	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (515 aa)
	ENSACLP00000027946	Uncharacterized protein. (112 aa)
	LOC113031724	Aquaporin 10a; Belongs to the MIP/aquaporin (TC 1.A.8) family. (283 aa)
	acsbg1	Acyl-CoA synthetase bubblegum family member 1. (695 aa)
	ENSACLP00000025326	Cytochrome P450 family 8 subfamily B member 1; Belongs to the cytochrome P450 family. (513 aa)
	LOC113011306	Uncharacterized protein. (521 aa)
	CYP8B1	Cytochrome P450 family 8 subfamily B member 1. (521 aa)
	LOC113031713	Acyl-CoA binding domain containing 7. (88 aa)
	PPARG	Peroxisome proliferator activated receptor gamma. (536 aa)
	LOC113015604	Uncharacterized protein; Belongs to the FGGY kinase family. (604 aa)
	ehhadh	Enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family. (719 aa)
	LOC113015054	Fatty acid binding protein 11a; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (134 aa)
	pltp	Phospholipid transfer protein. (495 aa)
	LOC113014215	Uncharacterized protein. (175 aa)
	acsl3	AMP-binding domain-containing protein. (719 aa)
	acox3	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (692 aa)
	fabp1	Fatty acid binding protein 1b, tandem duplicate 1. (127 aa)
	LOC113026694	Fatty acid desaturase 2. (445 aa)
	acsl6	AMP-binding domain-containing protein. (722 aa)
	ENSACLP00000019141	Stearoyl-CoA desaturase b; Belongs to the fatty acid desaturase type 1 family. (310 aa)
	scp2	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (562 aa)
	LOC113026692	Fatty acid desaturase 2. (445 aa)
	LOC113016569	Si:ch211-113j14.1; Belongs to the cytochrome P450 family. (535 aa)
	ENSACLP00000018109	Perilipin 6. (491 aa)
	pdpk1	3-phosphoinositide dependent protein kinase 1b. (565 aa)
	nr1h3	Nuclear receptor subfamily 1, group H, member 3. (464 aa)
	LOC113022767	Aquaporin 7; Belongs to the MIP/aquaporin (TC 1.A.8) family. (308 aa)
	LOC113012002	FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
	LOC113031003	Uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (312 aa)
	LOC113030915	Uncoupling protein 3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
	ENSACLP00000016344	Uncharacterized protein. (296 aa)
	acsbg2	Acyl-CoA synthetase bubblegum family member 2. (764 aa)
	ENSACLP00000015969	SIK family kinase 3. (1353 aa)
	aqp10	Aquaporin 10b; Belongs to the MIP/aquaporin (TC 1.A.8) family. (296 aa)
	acadl	Acyl-CoA dehydrogenase long chain. (442 aa)
	LOC113030103	Uncharacterized protein. (3518 aa)
	LOC113026627	Uncharacterized protein. (665 aa)
	LOC113026626	AMP-binding domain-containing protein. (665 aa)
	LOC113033638	Sorbin and SH3 domain containing 3. (806 aa)

Your Current Organism:

Astatotilapia calliptera

NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CYP8B1	ENSACLP00000019141	ENSACLP00000025244	ENSACLP00000019141	Cytochrome P450 family 8 subfamily B member 1.	Stearoyl-CoA desaturase b; Belongs to the fatty acid desaturase type 1 family.	0.404
CYP8B1	ENSACLP00000025326	ENSACLP00000025244	ENSACLP00000025326	Cytochrome P450 family 8 subfamily B member 1.	Cytochrome P450 family 8 subfamily B member 1; Belongs to the cytochrome P450 family.	0.683
CYP8B1	ENSACLP00000030567	ENSACLP00000025244	ENSACLP00000030567	Cytochrome P450 family 8 subfamily B member 1.	Si:dkey-91i10.3; Belongs to the cytochrome P450 family.	0.823
CYP8B1	LOC113007866	ENSACLP00000025244	ENSACLP00000004414	Cytochrome P450 family 8 subfamily B member 1.	Cytochrome P450, family 27, subfamily A, polypeptide 7; Belongs to the cytochrome P450 family.	0.823
CYP8B1	LOC113011007	ENSACLP00000025244	ENSACLP00000035537	Cytochrome P450 family 8 subfamily B member 1.	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	0.640
CYP8B1	LOC113011306	ENSACLP00000025244	ENSACLP00000025285	Cytochrome P450 family 8 subfamily B member 1.	Uncharacterized protein.	0.683
CYP8B1	LOC113016569	ENSACLP00000025244	ENSACLP00000018791	Cytochrome P450 family 8 subfamily B member 1.	Si:ch211-113j14.1; Belongs to the cytochrome P450 family.	0.823
CYP8B1	LOC113023871	ENSACLP00000025244	ENSACLP00000036160	Cytochrome P450 family 8 subfamily B member 1.	AMP-binding domain-containing protein.	0.478
CYP8B1	LOC113025280	ENSACLP00000025244	ENSACLP00000028034	Cytochrome P450 family 8 subfamily B member 1.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.736
CYP8B1	SCD	ENSACLP00000025244	ENSACLP00000007264	Cytochrome P450 family 8 subfamily B member 1.	Stearoyl-CoA desaturase; Belongs to the fatty acid desaturase type 1 family.	0.404
CYP8B1	acadl	ENSACLP00000025244	ENSACLP00000014282	Cytochrome P450 family 8 subfamily B member 1.	Acyl-CoA dehydrogenase long chain.	0.446
CYP8B1	acox1	ENSACLP00000025244	ENSACLP00000004885	Cytochrome P450 family 8 subfamily B member 1.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.503
CYP8B1	slc27a1	ENSACLP00000025244	ENSACLP00000031897	Cytochrome P450 family 8 subfamily B member 1.	Solute carrier family 27 member 1a.	0.566
DBI	LOC113007799	ENSACLP00000040758	ENSACLP00000009727	ACB domain-containing protein.	Diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein).	0.832
DBI	LOC113031713	ENSACLP00000040758	ENSACLP00000024957	ACB domain-containing protein.	Acyl-CoA binding domain containing 7.	0.830
DBI	acaa1	ENSACLP00000040758	ENSACLP00000003773	ACB domain-containing protein.	Acetyl-CoA acyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family.	0.738
DBI	acadl	ENSACLP00000040758	ENSACLP00000014282	ACB domain-containing protein.	Acyl-CoA dehydrogenase long chain.	0.673
DBI	acadm	ENSACLP00000040758	ENSACLP00000009237	ACB domain-containing protein.	Acyl-CoA dehydrogenase medium chain.	0.687
DBI	acox1	ENSACLP00000040758	ENSACLP00000004885	ACB domain-containing protein.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.762
DBI	acox3	ENSACLP00000040758	ENSACLP00000020371	ACB domain-containing protein.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.725