STRINGSTRING
mad1l1 mad1l1 gsk3b gsk3b PLK1 PLK1 ENSACLP00000002048 ENSACLP00000002048 anapc7 anapc7 ccne1 ccne1 espl1 espl1 LOC113020369 LOC113020369 ENSACLP00000006245 ENSACLP00000006245 ENSACLP00000006066 ENSACLP00000006066 ENSACLP00000005893 ENSACLP00000005893 mcm7 mcm7 cdk2 cdk2 LOC113036694 LOC113036694 cdk7 cdk7 LOC113009452 LOC113009452 LOC113009063 LOC113009063 cdk4 cdk4 bub1b bub1b ENSACLP00000004744 ENSACLP00000004744 ccna1 ccna1 LOC113037131 LOC113037131 ENSACLP00000004131 ENSACLP00000004131 LOC113006604 LOC113006604 ENSACLP00000004087 ENSACLP00000004087 GADD45B GADD45B LOC113032810 LOC113032810 FZR1 FZR1 LOC113033248 LOC113033248 tfdp1 tfdp1 LOC113035402 LOC113035402 ENSACLP00000035671 ENSACLP00000035671 ttk ttk ENSACLP00000034976 ENSACLP00000034976 ENSACLP00000034906 ENSACLP00000034906 LOC113019977 LOC113019977 LOC113010290 LOC113010290 ENSACLP00000034034 ENSACLP00000034034 cul1 cul1 cdk6 cdk6 LOC113030401 LOC113030401 LOC113022485 LOC113022485 LOC113022479 LOC113022479 wee1 wee1 LOC113016698 LOC113016698 LOC113026355 LOC113026355 LOC113025000 LOC113025000 orc1 orc1 TMEM82 TMEM82 CDKN2A CDKN2A cdc14a cdc14a ENSACLP00000030513 ENSACLP00000030513 ccnb3 ccnb3 LOC113009062 LOC113009062 orc5 orc5 HDAC1 HDAC1 HDAC2 HDAC2 ENSACLP00000028325 ENSACLP00000028325 LOC113036502 LOC113036502 rad21 rad21 LOC113012094 LOC113012094 hdac8 hdac8 ENSACLP00000027823 ENSACLP00000027823 mcm5 mcm5 LOC113027597 LOC113027597 mcm4 mcm4 orc2 orc2 cdc23 cdc23 ENSACLP00000026364 ENSACLP00000026364 LOC113007307 LOC113007307 ENSACLP00000025961 ENSACLP00000025961 LOC113033624 LOC113033624 mcm6 mcm6 dbf4 dbf4 anapc5 anapc5 anapc4 anapc4 orc3 orc3 ENSACLP00000025268 ENSACLP00000025268 LOC113014376 LOC113014376 mad2l2 mad2l2 tmem82 tmem82 snapin snapin LOC113021870 LOC113021870 fam126b fam126b cdc6 cdc6 ENSACLP00000024253 ENSACLP00000024253 CCND1 CCND1 SMAD3 SMAD3 ENSACLP00000023092 ENSACLP00000023092 zbtb10 zbtb10 ENSACLP00000002506 ENSACLP00000002506 LOC113036202 LOC113036202 e2f2 e2f2 ENSACLP00000022602 ENSACLP00000022602 smad3 smad3 ENSACLP00000021745 ENSACLP00000021745 ENSACLP00000021730 ENSACLP00000021730 LOC113025730 LOC113025730 skp1 skp1 gadd45g gadd45g LOC113014748 LOC113014748 e2f1 e2f1 LOC113021131 LOC113021131 cdc27 cdc27 rbx1 rbx1 LOC113033065 LOC113033065 ENSACLP00000020481 ENSACLP00000020481 E2F3 E2F3 LOC113009944 LOC113009944 LOC113014899 LOC113014899 cdkn1b cdkn1b cdc16 cdc16 GADD45A GADD45A ENSACLP00000040195 ENSACLP00000040195 ccnb1 ccnb1 LOC113020749 LOC113020749 LOC113027366 LOC113027366 LOC113027367 LOC113027367 LOC113011971 LOC113011971 YWHAB YWHAB ENSACLP00000036875 ENSACLP00000036875 ENSACLP00000036881 ENSACLP00000036881 LOC113025941 LOC113025941 smc3 smc3 cntd2 cntd2 ENSACLP00000037904 ENSACLP00000037904 LOC113027446 LOC113027446 zbtb46 zbtb46 ENSACLP00000038411 ENSACLP00000038411 LOC113008396 LOC113008396 cdc25b cdc25b abl1 abl1 ap5s1 ap5s1 ENSACLP00000019391 ENSACLP00000019391 LOC113031225 LOC113031225 rb1 rb1 TGFB3 TGFB3 mdm2 mdm2 ENSACLP00000018094 ENSACLP00000018094 ENSACLP00000018067 ENSACLP00000018067 anapc10 anapc10 skp2 skp2 LOC113032586 LOC113032586 LOC113031082 LOC113031082 LOC113010824 LOC113010824 pcna pcna anapc13 anapc13 ENSACLP00000016742 ENSACLP00000016742 cdc45 cdc45 LOC113015757 LOC113015757 LOC113027151 LOC113027151 pkmyt1 pkmyt1 ENSACLP00000015199 ENSACLP00000015199 GADD45B-2 GADD45B-2 LOC113031427 LOC113031427 chek2 chek2 cdc7 cdc7 LOC113011288 LOC113011288 mcm3 mcm3 LOC113027124 LOC113027124 ENSACLP00000012049 ENSACLP00000012049 cdkn2d cdkn2d ENSACLP00000011103 ENSACLP00000011103 LOC113022176 LOC113022176 snph snph mcm2 mcm2 stag1 stag1 ENSACLP00000008418 ENSACLP00000008418 ENSACLP00000008410 ENSACLP00000008410 ENSACLP00000008384 ENSACLP00000008384 ENSACLP00000008361 ENSACLP00000008361 ccnh ccnh LOC113030590 LOC113030590 ENSACLP00000007272 ENSACLP00000007272 LOC113023392 LOC113023392 smc1a smc1a LOC113018712 LOC113018712
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mad1l1Mitotic arrest deficient 1 like 1. (720 aa)
gsk3bGlycogen synthase kinase 3 beta, genome duplicate b; Belongs to the protein kinase superfamily. (425 aa)
PLK1Serine/threonine-protein kinase PLK. (582 aa)
ENSACLP00000002048Zinc finger protein 652. (469 aa)
anapc7Anaphase promoting complex subunit 7. (565 aa)
ccne1Cyclin E1; Belongs to the cyclin family. (428 aa)
espl1Extra spindle pole bodies like 1, separase. (2169 aa)
LOC113020369Cyclin-dependent kinase 21; Belongs to the protein kinase superfamily. (300 aa)
ENSACLP00000006245Protein kinase domain-containing protein. (194 aa)
ENSACLP00000006066BUB3 mitotic checkpoint protein. (324 aa)
ENSACLP00000005893SCD domain-containing protein. (1191 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (740 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
LOC1130366943-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 2; Belongs to the 14-3-3 family. (247 aa)
cdk7Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (343 aa)
LOC113009452Uncharacterized protein. (178 aa)
LOC113009063Uncharacterized protein. (181 aa)
cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (306 aa)
bub1bBUB1 mitotic checkpoint serine/threonine kinase Bb. (426 aa)
ENSACLP00000004744Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (414 aa)
ccna1Cyclin A1; Belongs to the cyclin family. (398 aa)
LOC113037131Ribosomal_L7Ae domain-containing protein. (166 aa)
ENSACLP00000004131TAN domain-containing protein. (177 aa)
LOC113006604Growth arrest and DNA damage inducible beta. (161 aa)
ENSACLP00000004087Uncharacterized protein. (139 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
LOC113032810Cyclin E2; Belongs to the cyclin family. (391 aa)
FZR1Fizzy/cell division cycle 20 related 1a. (496 aa)
LOC113033248Mothers against decapentaplegic homolog. (489 aa)
tfdp1Transcription factor. (413 aa)
LOC113035402Cyclin B2; Belongs to the cyclin family. (386 aa)
ENSACLP00000035671Cell division cycle 20 homolog. (492 aa)
ttkTtk protein kinase. (1006 aa)
ENSACLP00000034976Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4). (127 aa)
ENSACLP00000034906Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4). (159 aa)
LOC113019977Cyclin Dx; Belongs to the cyclin family. (317 aa)
LOC113010290Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (368 aa)
ENSACLP00000034034Uncharacterized protein. (545 aa)
cul1Cullin 1b; Belongs to the cullin family. (776 aa)
cdk6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (325 aa)
LOC113030401Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 2; Belongs to the 14-3-3 family. (255 aa)
LOC113022485Cyclin-dependent kinase inhibitor 1A. (165 aa)
LOC113022479Cyclin D3; Belongs to the cyclin family. (317 aa)
wee1Wee1-like protein kinase. (622 aa)
LOC113016698WD_REPEATS_REGION domain-containing protein. (518 aa)
LOC113026355Structural maintenance of chromosomes protein. (1245 aa)
LOC113025000Retinoblastoma-like 2 (p130). (1098 aa)
orc1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (899 aa)
TMEM82Transmembrane protein 82. (344 aa)
CDKN2ACyclin dependent kinase inhibitor 2A. (131 aa)
cdc14aCell division cycle 14Ab. (674 aa)
ENSACLP00000030513Checkpoint kinase 1; Belongs to the protein kinase superfamily. (469 aa)
ccnb3Cyclin B3; Belongs to the cyclin family. (431 aa)
LOC113009062Cyclin D2, b; Belongs to the cyclin family. (294 aa)
orc5Origin recognition complex, subunit 5. (450 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (484 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (489 aa)
ENSACLP00000028325Cell division cycle 26 homolog. (87 aa)
LOC113036502Transforming growth factor beta; Belongs to the TGF-beta family. (383 aa)
rad21RAD21 cohesin complex component a. (635 aa)
LOC113012094Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b; Belongs to the 14-3-3 family. (247 aa)
hdac8Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (387 aa)
ENSACLP00000027823Anaphase promoting complex subunit 2; Belongs to the cullin family. (819 aa)
mcm5DNA helicase; Belongs to the MCM family. (737 aa)
LOC113027597E1A binding protein p300 a. (2787 aa)
mcm4DNA helicase; Belongs to the MCM family. (860 aa)
orc2Uncharacterized protein. (576 aa)
cdc23CDC23 (cell division cycle 23, yeast, homolog). (595 aa)
ENSACLP00000026364Uncharacterized protein. (371 aa)
LOC113007307Transforming growth factor beta; Belongs to the TGF-beta family. (420 aa)
ENSACLP00000025961Uncharacterized protein. (159 aa)
LOC113033624Mothers against decapentaplegic homolog. (510 aa)
mcm6DNA helicase; Belongs to the MCM family. (828 aa)
dbf4DBF4 zinc finger. (637 aa)
anapc5Anaphase promoting complex subunit 5. (771 aa)
anapc4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (807 aa)
orc3Origin recognition complex, subunit 3. (720 aa)
ENSACLP00000025268Retinoblastoma-like 1 (p107). (1067 aa)
LOC113014376Mothers against decapentaplegic homolog. (607 aa)
mad2l2Mitotic arrest deficient 2 like 2. (210 aa)
tmem82Transmembrane protein 82. (348 aa)
snapinSNAP associated protein. (156 aa)
LOC113021870Si:dkey-222f2.1; Belongs to the intermediate filament family. (451 aa)
fam126bZgc:158316. (615 aa)
cdc6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (602 aa)
ENSACLP00000024253Zinc finger and BTB domain containing 17. (775 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (293 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
ENSACLP00000023092Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4053 aa)
zbtb10Zinc finger and BTB domain containing 10. (740 aa)
ENSACLP00000002506Uncharacterized protein. (179 aa)
LOC11303620214_3_3 domain-containing protein; Belongs to the 14-3-3 family. (277 aa)
e2f2Si:ch211-160f23.5. (448 aa)
ENSACLP00000022602Mothers against decapentaplegic homolog. (494 aa)
smad3Mothers against decapentaplegic homolog. (425 aa)
ENSACLP00000021745Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (434 aa)
ENSACLP00000021730Uncharacterized protein. (436 aa)
LOC113025730Mothers against decapentaplegic homolog. (503 aa)
skp1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
gadd45gGrowth arrest and DNA-damage-inducible, gamma a. (159 aa)
LOC113014748Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; Belongs to the 14-3-3 family. (263 aa)
e2f1E2F transcription factor 1. (454 aa)
LOC113021131E1A binding protein p300 b. (2771 aa)
cdc27Cell division cycle 27. (807 aa)
rbx1Ring-box 1, E3 ubiquitin protein ligase. (107 aa)
LOC113033065Uncharacterized protein. (589 aa)
ENSACLP00000020481E2F_CC-MB domain-containing protein. (233 aa)
E2F3E2F transcription factor 3. (445 aa)
LOC113009944Fizzy/cell division cycle 20 related 1b. (531 aa)
LOC113014899Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
cdkn1bCyclin-dependent kinase inhibitor 1Bb. (184 aa)
cdc16Cell division cycle 16 homolog (S. cerevisiae). (619 aa)
GADD45AGrowth arrest and DNA-damage-inducible, alpha, b. (177 aa)
ENSACLP00000040195Zinc finger and BTB domain containing 47b. (648 aa)
ccnb1Cyclin B1; Belongs to the cyclin family. (399 aa)
LOC113020749CREB binding protein b. (2474 aa)
LOC113027366Ribosomal_L7Ae domain-containing protein. (157 aa)
LOC113027367Growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1. (154 aa)
LOC113011971Transforming growth factor beta; Belongs to the TGF-beta family. (405 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b; Belongs to the 14-3-3 family. (244 aa)
ENSACLP00000036875Stromal antigen 2b. (1278 aa)
ENSACLP00000036881CREB binding protein a. (2436 aa)
LOC113025941Mothers against decapentaplegic homolog. (472 aa)
smc3Structural maintenance of chromosomes protein. (1217 aa)
cntd2Cyclin N-terminal domain containing 2; Belongs to the cyclin family. (406 aa)
ENSACLP00000037904Anaphase promoting complex subunit 1. (1883 aa)
LOC113027446Cyclin-dependent kinase inhibitor 1Cb. (208 aa)
zbtb46Zinc finger and BTB domain containing 46. (861 aa)
ENSACLP00000038411Cell division cycle 20 homolog. (361 aa)
LOC113008396Si:ch211-269e2.1. (1185 aa)
cdc25bRhodanese domain-containing protein. (571 aa)
abl1Tyrosine-protein kinase. (1104 aa)
ap5s1Adaptor related protein complex 5 subunit sigma 1. (200 aa)
ENSACLP00000019391Cyclin-dependent kinase 20. (531 aa)
LOC113031225Cyclin A2; Belongs to the cyclin family. (440 aa)
rb1Retinoblastoma 1. (912 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (408 aa)
mdm2MDM2 proto-oncogene. (523 aa)
ENSACLP00000018094Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (211 aa)
ENSACLP00000018067BUB1 N-terminal domain-containing protein. (85 aa)
anapc10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (186 aa)
skp2S-phase kinase-associated protein 2, E3 ubiquitin protein ligase. (416 aa)
LOC113032586Uncharacterized protein. (799 aa)
LOC113031082Stromal antigen 2a. (1276 aa)
LOC113010824E2F transcription factor 5. (385 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
anapc13Anaphase promoting complex subunit 13. (74 aa)
ENSACLP00000016742E2F transcription factor 4. (373 aa)
cdc45CDC45 cell division cycle 45 homolog (S. cerevisiae). (568 aa)
LOC113015757Uncharacterized protein. (156 aa)
LOC113027151Cyclin D2, a; Belongs to the cyclin family. (297 aa)
pkmyt1Protein kinase, membrane associated tyrosine/threonine 1. (583 aa)
ENSACLP00000015199APC11 anaphase promoting complex subunit 11 homolog (yeast). (94 aa)
GADD45B-2Growth arrest and DNA damage inducible beta. (214 aa)
LOC11303142714_3_3 domain-containing protein; Belongs to the 14-3-3 family. (246 aa)
chek2Checkpoint kinase 2. (523 aa)
cdc7Cell division cycle 7 homolog (S. cerevisiae). (611 aa)
LOC113011288Growth arrest and DNA-damage-inducible, alpha, a. (163 aa)
mcm3DNA helicase; Belongs to the MCM family. (811 aa)
LOC113027124Wee1-like protein kinase. (547 aa)
ENSACLP00000012049Myelocytomatosis oncogene homolog. (336 aa)
cdkn2dCyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4). (164 aa)
ENSACLP00000011103Transforming growth factor beta; Belongs to the TGF-beta family. (403 aa)
LOC11302217614_3_3 domain-containing protein; Belongs to the 14-3-3 family. (244 aa)
snphSyntaphilin b. (877 aa)
mcm2DNA helicase; Belongs to the MCM family. (886 aa)
stag1Stromal antigen 1a. (1266 aa)
ENSACLP00000008418MAD2 mitotic arrest deficient-like 1 (yeast). (205 aa)
ENSACLP00000008410annotation not available (228 aa)
ENSACLP00000008384ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2524 aa)
ENSACLP00000008361MAD2 mitotic arrest deficient-like 1 (yeast). (215 aa)
ccnhCyclin H; Belongs to the cyclin family. (350 aa)
LOC1130305903-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 1; Belongs to the 14-3-3 family. (247 aa)
ENSACLP00000007272Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (276 aa)
LOC113023392E2F_TDP domain-containing protein. (307 aa)
smc1aStructural maintenance of chromosomes protein. (1231 aa)
LOC113018712Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (384 aa)
Your Current Organism:
Astatotilapia calliptera
NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy
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