(99 nodes) VEGF signaling pathway network (Astatotilapia calliptera)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSACLP00000034020	Uncharacterized protein. (400 aa)
	LOC113034924	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (489 aa)
	LOC113016221	Mitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily. (421 aa)
	ENSACLP00000034800	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (215 aa)
	akt2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
	MAPKAPK3	MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (421 aa)
	LOC113025755	Heat shock protein, alpha-crystallin-related, b15; Belongs to the small heat shock protein (HSP20) family. (209 aa)
	kdr	Kinase insert domain receptor (a type III receptor tyrosine kinase). (1356 aa)
	LOC113015070	Uncharacterized protein. (184 aa)
	LOC113015067	Cell division cycle 42, like. (202 aa)
	ENSACLP00000023060	Cell division cycle 42, like. (191 aa)
	LOC113015068	Cell division cycle 42, like. (191 aa)
	ENSACLP00000022835	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (352 aa)
	LOC113013019	Mitogen-activated protein kinase. (363 aa)
	RAC1	Rac family small GTPase 1. (185 aa)
	LOC113019652	Zgc:158659; Belongs to the PI3/PI4-kinase family. (1070 aa)
	ENSACLP00000019586	Protein tyrosine kinase 2ab; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1083 aa)
	CSDE1	Cold shock domain containing E1, RNA-binding. (798 aa)
	LOC113010606	Phosphoinositide-3-kinase, regulatory subunit 3a (gamma). (467 aa)
	pik3cb	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1078 aa)
	LOC113015401	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1098 aa)
	LOC113013098	Mitogen-activated protein kinase. (364 aa)
	ENSACLP00000016066	Uncharacterized protein. (961 aa)
	LOC113010568	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	LOC113026190	Serine/threonine-protein phosphatase. (514 aa)
	TGFB1I1	Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (462 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (680 aa)
	ptgs2	Prostaglandin-endoperoxide synthase 2b. (620 aa)
	pla2g4a	Phospholipase A2. (745 aa)
	SPHK1-2	Sphingosine kinase 1. (562 aa)
	vegfa	Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family. (214 aa)
	LOC113009682	Mitogen-activated protein kinase. (360 aa)
	LOC113009105	Mitogen-activated protein kinase. (361 aa)
	LOC113024639	Uncharacterized protein. (192 aa)
	LOC113021014	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (394 aa)
	ENSACLP00000011420	GTP binding protein overexpressed in skeletal muscle. (297 aa)
	LOC113022696	Mitogen-activated protein kinase. (361 aa)
	ENSACLP00000011022	Phosphoinositide-3-kinase, regulatory subunit 2 (beta). (694 aa)
	ENSACLP00000010976	Uncharacterized protein. (174 aa)
	LOC113020994	Zgc:55558. (187 aa)
	LOC113033441	Uncharacterized protein. (717 aa)
	mapkapk2	MAPK activated protein kinase 2a; Belongs to the protein kinase superfamily. (389 aa)
	LOC113033345	Serine/threonine-protein phosphatase. (506 aa)
	hspb1	Heat shock protein, alpha-crystallin-related, 1; Belongs to the small heat shock protein (HSP20) family. (203 aa)
	LOC113021353	PLA2c domain-containing protein. (585 aa)
	ENSACLP00000007088	PLA2c domain-containing protein. (509 aa)
	LOC113030100	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	LOC113027092	Mitogen-activated protein kinase. (365 aa)
	mapk1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa)
	SPHK1	Sphingosine kinase 1. (427 aa)
	REM1	RRAD and GEM like GTPase 1. (308 aa)
	akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
	ENSACLP00000004729	Uncharacterized protein. (170 aa)
	ENSACLP00000003860	Protein phosphatase 3 (formerly 2B), regulatory s1ubunit B, alpha isoform, b. (182 aa)
	LOC113011047	Mitogen-activated protein kinase kinase 2b. (395 aa)
	prkca	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (680 aa)
	LOC113012864	Mitogen-activated protein kinase. (361 aa)
	ENSACLP00000002578	SH2 domain-containing protein. (82 aa)
	hras	HRas proto-oncogene, GTPase a. (189 aa)
	lrrc45	Leucine rich repeat containing 45. (674 aa)
	LOC113027755	Rac family small GTPase 3b. (192 aa)
	plcg2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1249 aa)
	LOC113016116	SHC (Src homology 2 domain containing) transforming protein 2. (726 aa)
	LOC113024427	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (667 aa)
	lpxn	Leupaxin. (399 aa)
	LOC113031477	Uncharacterized protein. (191 aa)
	LOC113022989	Cell division cycle 42. (191 aa)
	rrad	Ras-related associated with diabetes. (309 aa)
	pik3cd	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1039 aa)
	ppp3r1	Uncharacterized protein. (174 aa)
	plcg1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1311 aa)
	LOC113008803	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	pik3r1	Phosphoinositide-3-kinase, regulatory subunit 1 (alpha). (729 aa)
	KRAS	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (217 aa)
	KRAS-2	KRAS proto-oncogene, GTPase. (217 aa)
	LOC113020808	Uncharacterized protein. (195 aa)
	LOC113020809	Uncharacterized protein. (192 aa)
	LOC113020810	Uncharacterized protein. (192 aa)
	LOC113020814	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (680 aa)
	jmjd7	Jumonji domain containing 7. (312 aa)
	ENSACLP00000025003	Rac family small GTPase 2. (156 aa)
	LOC113013184	Tyrosine-protein kinase. (552 aa)
	nfatc2	Nuclear factor of activated T cells 2a. (895 aa)
	casp9	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (423 aa)
	vegfb	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (265 aa)
	LOC113022853	MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (412 aa)
	LOC113030393	Serine/threonine-protein phosphatase. (522 aa)
	LOC113033101	Paxillin b. (1174 aa)
	ENSACLP00000023703	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (394 aa)
	LOC113031460	Sphingosine kinase 2. (899 aa)
	bad	BCL2 associated agonist of cell death b. (158 aa)
	SRC	Tyrosine-protein kinase. (550 aa)
	LOC113021993	RHD domain-containing protein. (884 aa)
	ppp1r14b	Protein phosphatase 1, regulatory (inhibitor) subunit 14Bb. (210 aa)
	LOC113032875	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (704 aa)
	LOC113009053	Phosphoinositide-3-kinase, regulatory subunit 3b (gamma). (698 aa)
	ppp3ca	Serine/threonine-protein phosphatase. (685 aa)
	LOC113009003	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1312 aa)
	LOC113033416	Serine/threonine-protein phosphatase. (511 aa)

Your Current Organism:

Astatotilapia calliptera

NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSDE1	ENSACLP00000004729	ENSACLP00000019557	ENSACLP00000004729	Cold shock domain containing E1, RNA-binding.	Uncharacterized protein.	0.507
CSDE1	ENSACLP00000010976	ENSACLP00000019557	ENSACLP00000010976	Cold shock domain containing E1, RNA-binding.	Uncharacterized protein.	0.507
CSDE1	ENSACLP00000011022	ENSACLP00000019557	ENSACLP00000011022	Cold shock domain containing E1, RNA-binding.	Phosphoinositide-3-kinase, regulatory subunit 2 (beta).	0.638
CSDE1	ENSACLP00000011420	ENSACLP00000019557	ENSACLP00000011420	Cold shock domain containing E1, RNA-binding.	GTP binding protein overexpressed in skeletal muscle.	0.453
CSDE1	ENSACLP00000022835	ENSACLP00000019557	ENSACLP00000022835	Cold shock domain containing E1, RNA-binding.	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily.	0.699
CSDE1	ENSACLP00000023060	ENSACLP00000019557	ENSACLP00000023060	Cold shock domain containing E1, RNA-binding.	Cell division cycle 42, like.	0.507
CSDE1	ENSACLP00000023703	ENSACLP00000019557	ENSACLP00000023703	Cold shock domain containing E1, RNA-binding.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.422
CSDE1	ENSACLP00000025003	ENSACLP00000019557	ENSACLP00000025003	Cold shock domain containing E1, RNA-binding.	Rac family small GTPase 2.	0.507
CSDE1	ENSACLP00000034020	ENSACLP00000019557	ENSACLP00000034020	Cold shock domain containing E1, RNA-binding.	Uncharacterized protein.	0.779
CSDE1	LOC113008803	ENSACLP00000019557	ENSACLP00000038993	Cold shock domain containing E1, RNA-binding.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.691
CSDE1	LOC113009053	ENSACLP00000019557	ENSACLP00000032720	Cold shock domain containing E1, RNA-binding.	Phosphoinositide-3-kinase, regulatory subunit 3b (gamma).	0.638
CSDE1	LOC113009105	ENSACLP00000019557	ENSACLP00000012131	Cold shock domain containing E1, RNA-binding.	Mitogen-activated protein kinase.	0.578
CSDE1	LOC113009682	ENSACLP00000019557	ENSACLP00000012160	Cold shock domain containing E1, RNA-binding.	Mitogen-activated protein kinase.	0.578
CSDE1	LOC113010568	ENSACLP00000019557	ENSACLP00000015873	Cold shock domain containing E1, RNA-binding.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.691
CSDE1	LOC113010606	ENSACLP00000019557	ENSACLP00000018537	Cold shock domain containing E1, RNA-binding.	Phosphoinositide-3-kinase, regulatory subunit 3a (gamma).	0.779
CSDE1	LOC113011047	ENSACLP00000019557	ENSACLP00000003805	Cold shock domain containing E1, RNA-binding.	Mitogen-activated protein kinase kinase 2b.	0.699
CSDE1	LOC113012864	ENSACLP00000019557	ENSACLP00000003196	Cold shock domain containing E1, RNA-binding.	Mitogen-activated protein kinase.	0.578
CSDE1	LOC113013019	ENSACLP00000019557	ENSACLP00000022542	Cold shock domain containing E1, RNA-binding.	Mitogen-activated protein kinase.	0.578
CSDE1	LOC113013098	ENSACLP00000019557	ENSACLP00000017084	Cold shock domain containing E1, RNA-binding.	Mitogen-activated protein kinase.	0.578
CSDE1	LOC113013184	ENSACLP00000019557	ENSACLP00000025858	Cold shock domain containing E1, RNA-binding.	Tyrosine-protein kinase.	0.646