(54 nodes) Phototransduction network (Astatotilapia calliptera)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC113007780	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (561 aa)
	LOC113023908	Uncharacterized protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (625 aa)
	SLC24A2	Solute carrier family 24 member 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (633 aa)
	LOC113030381	Guanylate cyclase activator 1d. (188 aa)
	LOC113013062	Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2. (350 aa)
	LOC113037255	Guanylate cyclase activator 1g. (190 aa)
	LOC113036706	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (545 aa)
	ENSACLP00000010823	Cyclic nucleotide gated channel subunit alpha 1b. (643 aa)
	SLC24A1	Solute carrier family 24 member 1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (715 aa)
	SAG	S-antigen visual arrestin. (381 aa)
	grk7	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (557 aa)
	LOC113024089	Uncharacterized protein. (73 aa)
	LOC113021489	Regulator of G protein signaling 9a. (481 aa)
	guca1b	Guanylate cyclase activator 1B. (197 aa)
	LOC113022254	Rhodopsin. (352 aa)
	ENSACLP00000016208	Rhodopsin. (345 aa)
	LOC113022256	Rhodopsin. (353 aa)
	ENSACLP00000016897	Si:dkey-44k1.5. (800 aa)
	LOC113022288	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fa; Belongs to the semaphorin family. (934 aa)
	LOC113022290	Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1. (350 aa)
	ENSACLP00000020243	Protein kinase domain-containing protein. (259 aa)
	LOC113022298	Guanine nucleotide binding protein (G protein), beta polypeptide 1b. (340 aa)
	LOC113031017	Guanylate cyclase. (1154 aa)
	CALML6	Calmodulin like 6. (136 aa)
	ENSACLP00000020804	Calmodulin-like 4a. (117 aa)
	LOC113030387	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (559 aa)
	rgs11	Regulator of G protein signaling 11. (470 aa)
	slc24a1	Solute carrier family 24 member 1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (736 aa)
	calm1	Calmodulin 2a (phosphorylase kinase, delta); Belongs to the calmodulin family. (149 aa)
	LOC113015211	Recoverin 3. (192 aa)
	LOC113013015	Guanine nucleotide binding protein (G protein), beta polypeptide 1a. (340 aa)
	calm1-2	Calmodulin 3a (phosphorylase kinase, delta); Belongs to the calmodulin family. (230 aa)
	pde6a	Phosphodiesterase. (857 aa)
	ENSACLP00000027557	Cyclic nucleotide gated channel subunit alpha 1a. (645 aa)
	LOC113019077	Guanylate cyclase. (1142 aa)
	LOC113025835	Phosphodiesterase. (855 aa)
	guca1a	Guanylate cyclase activator 1A. (202 aa)
	rcvrn	Recoverin a. (207 aa)
	pde6g	Phosphodiesterase 6G, cGMP-specific, rod, gamma, paralog b. (87 aa)
	ENSACLP00000032103	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fb; Belongs to the semaphorin family. (805 aa)
	LOC113031788	Recoverin 2. (193 aa)
	ENSACLP00000034132	Calmodulin-like 4b. (176 aa)
	ENSACLP00000034575	S-antigen; retina and pineal gland (arrestin) a. (384 aa)
	LOC113014465	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
	LOC113036738	Guanylate cyclase activator 1C. (189 aa)
	calm1-3	Calmodulin. (149 aa)
	ENSACLP00000035593	Transmembrane and coiled-coil domains 3. (680 aa)
	grk1	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (563 aa)
	ENSACLP00000035853	Cyclic nucleotide gated channel subunit alpha 3a. (671 aa)
	ENSACLP00000035854	Guanylate cyclase. (1100 aa)
	ENSACLP00000036864	Cyclic nucleotide gated channel beta 1a. (1137 aa)
	LOC113020676	Phosphodiesterase 6G, cGMP-specific, rod, gamma, paralog a. (90 aa)
	ENSACLP00000037109	Uncharacterized protein; Belongs to the calmodulin family. (321 aa)
	ENSACLP00000039681	Regulator of G protein signaling 9b. (679 aa)

Your Current Organism:

Astatotilapia calliptera

NCBI taxonomy Id: 8154
Other names: A. calliptera, Ctenochromis callipterus, Haplochromis calliptera, Haplochromis callipterus, eastern happy

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CALML6	ENSACLP00000010823	ENSACLP00000020713	ENSACLP00000010823	Calmodulin like 6.	Cyclic nucleotide gated channel subunit alpha 1b.	0.836
CALML6	ENSACLP00000016897	ENSACLP00000020713	ENSACLP00000016897	Calmodulin like 6.	Si:dkey-44k1.5.	0.882
CALML6	ENSACLP00000027557	ENSACLP00000020713	ENSACLP00000027557	Calmodulin like 6.	Cyclic nucleotide gated channel subunit alpha 1a.	0.856
CALML6	ENSACLP00000035853	ENSACLP00000020713	ENSACLP00000035853	Calmodulin like 6.	Cyclic nucleotide gated channel subunit alpha 3a.	0.836
CALML6	ENSACLP00000036864	ENSACLP00000020713	ENSACLP00000036864	Calmodulin like 6.	Cyclic nucleotide gated channel beta 1a.	0.882
CALML6	ENSACLP00000037109	ENSACLP00000020713	ENSACLP00000037109	Calmodulin like 6.	Uncharacterized protein; Belongs to the calmodulin family.	0.826
CALML6	LOC113007780	ENSACLP00000020713	ENSACLP00000002948	Calmodulin like 6.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.427
CALML6	LOC113015211	ENSACLP00000020713	ENSACLP00000024659	Calmodulin like 6.	Recoverin 3.	0.438
CALML6	LOC113030381	ENSACLP00000020713	ENSACLP00000000926	Calmodulin like 6.	Guanylate cyclase activator 1d.	0.426
CALML6	LOC113030387	ENSACLP00000020713	ENSACLP00000020891	Calmodulin like 6.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.427
CALML6	LOC113031788	ENSACLP00000020713	ENSACLP00000033035	Calmodulin like 6.	Recoverin 2.	0.438
CALML6	LOC113036706	ENSACLP00000020713	ENSACLP00000010308	Calmodulin like 6.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.515
CALML6	calm1	ENSACLP00000020713	ENSACLP00000024326	Calmodulin like 6.	Calmodulin 2a (phosphorylase kinase, delta); Belongs to the calmodulin family.	0.826
CALML6	calm1-2	ENSACLP00000020713	ENSACLP00000025637	Calmodulin like 6.	Calmodulin 3a (phosphorylase kinase, delta); Belongs to the calmodulin family.	0.826
CALML6	calm1-3	ENSACLP00000020713	ENSACLP00000035079	Calmodulin like 6.	Calmodulin.	0.826
CALML6	grk1	ENSACLP00000020713	ENSACLP00000035657	Calmodulin like 6.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.427
CALML6	grk7	ENSACLP00000020713	ENSACLP00000013988	Calmodulin like 6.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.515
CALML6	guca1a	ENSACLP00000020713	ENSACLP00000029640	Calmodulin like 6.	Guanylate cyclase activator 1A.	0.499
CALML6	rcvrn	ENSACLP00000020713	ENSACLP00000030576	Calmodulin like 6.	Recoverin a.	0.438
ENSACLP00000010823	CALML6	ENSACLP00000010823	ENSACLP00000020713	Cyclic nucleotide gated channel subunit alpha 1b.	Calmodulin like 6.	0.836