(64 nodes) Negative regulation of epithelial cell proliferation network (Perca flavescens)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A484DIJ9	Transforming growth factor beta; Belongs to the TGF-beta family. (384 aa)
	A0A484BYD2	Protein kinase domain-containing protein. (152 aa)
	A0A484BZ77	Uncharacterized protein; Belongs to the MAGUK family. (691 aa)
	A0A484C0R9	Homeobox domain-containing protein. (260 aa)
	A0A484C222	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1825 aa)
	A0A484C3B7	Uncharacterized protein. (979 aa)
	A0A484C3T5	Protein kinase domain-containing protein. (223 aa)
	A0A484C4R2	Uncharacterized protein. (613 aa)
	A0A484C560	Uncharacterized protein. (176 aa)
	A0A484C575	RING-type domain-containing protein. (328 aa)
	A0A484C9V9	Uncharacterized protein. (438 aa)
	A0A484CA32	Uncharacterized protein. (86 aa)
	A0A484CAS3	Uncharacterized protein. (335 aa)
	A0A484CBV5	Uncharacterized protein. (410 aa)
	A0A484CCB9	EMI domain-containing protein. (908 aa)
	A0A484CEB8	tRNA-binding domain-containing protein. (143 aa)
	A0A484CEE8	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (594 aa)
	A0A484CFS8	Uncharacterized protein. (370 aa)
	A0A484CHE7	Uncharacterized protein. (353 aa)
	A0A484CI09	Uncharacterized protein. (98 aa)
	A0A484CII3	Uncharacterized protein. (256 aa)
	A0A484CK55	PID domain-containing protein. (598 aa)
	A0A484CM18	Uncharacterized protein. (914 aa)
	A0A484CQ29	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (459 aa)
	A0A484CQ56	Uncharacterized protein. (530 aa)
	A0A484CQI5	BRICHOS domain-containing protein. (315 aa)
	A0A484CRI3	Uncharacterized protein. (879 aa)
	A0A484CS61	Uncharacterized protein; Belongs to the MAGUK family. (951 aa)
	A0A484CSS5	EAF domain-containing protein. (264 aa)
	A0A484CUL5	Uncharacterized protein. (126 aa)
	A0A484CVB0	BRICHOS domain-containing protein. (293 aa)
	A0A484CVS7	LIM domain-containing protein. (395 aa)
	A0A484CWR1	Homeobox domain-containing protein. (285 aa)
	A0A484CWY4	BRICHOS domain-containing protein. (299 aa)
	A0A484CX60	Transforming growth factor beta; Belongs to the TGF-beta family. (420 aa)
	A0A484CYH4	Uncharacterized protein. (683 aa)
	A0A484D0I3	MCC-bdg_PDZ domain-containing protein. (716 aa)
	A0A484D255	Uncharacterized protein. (216 aa)
	A0A484D266	Uncharacterized protein. (185 aa)
	A0A484D4L7	Uncharacterized protein. (531 aa)
	A0A484D5X1	Uncharacterized protein. (506 aa)
	A0A484D8A4	UDENN FLCN/SMCR8-type domain-containing protein. (582 aa)
	A0A484D9H3	Transforming growth factor beta; Belongs to the TGF-beta family. (413 aa)
	A0A484DAA8	Uncharacterized protein. (396 aa)
	A0A484DAD6	Uncharacterized protein. (1085 aa)
	A0A484DC43	Uncharacterized protein; Belongs to the peptidase S1 family. (427 aa)
	A0A484DCK6	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (551 aa)
	A0A484DDU5	Homeobox domain-containing protein. (205 aa)
	A0A484DET3	Uncharacterized protein. (185 aa)
	A0A484DFZ9	WD_REPEATS_REGION domain-containing protein. (337 aa)
	A0A484DH14	ABC_transp_aux domain-containing protein. (457 aa)
	A0A484DH53	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (166 aa)
	A0A484DHC1	WD_REPEATS_REGION domain-containing protein. (810 aa)
	A0A484DIJ3	Uncharacterized protein. (341 aa)
	A0A484DJ52	Uncharacterized protein. (2755 aa)
	A0A484DJM2	Tower domain-containing protein. (2986 aa)
	A0A484DK56	Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (271 aa)
	A0A484DKI9	Uncharacterized protein. (354 aa)
	A0A484DLG7	tRNA-binding domain-containing protein. (305 aa)
	A0A484DM48	Uncharacterized protein. (295 aa)
	A0A484DMA2	tRNA-binding domain-containing protein. (343 aa)
	A0A484DMP7	Uncharacterized protein. (365 aa)
	A0A484DNC1	LIM domain-containing protein. (335 aa)
	A0A484DNH5	ANK_REP_REGION domain-containing protein. (124 aa)

Your Current Organism:

Perca flavescens

NCBI taxonomy Id: 8167
Other names: Morone flavescens, P. flavescens, yellow perch

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A484BYD2	A0A484BZ77	Protein kinase domain-containing protein.	Uncharacterized protein; Belongs to the MAGUK family.	0.976
A0A484BYD2	A0A484C3T5	Protein kinase domain-containing protein.	Protein kinase domain-containing protein.	0.987
A0A484BYD2	A0A484C4R2	Protein kinase domain-containing protein.	Uncharacterized protein.	0.494
A0A484BYD2	A0A484CCB9	Protein kinase domain-containing protein.	EMI domain-containing protein.	0.494
A0A484BYD2	A0A484CS61	Protein kinase domain-containing protein.	Uncharacterized protein; Belongs to the MAGUK family.	0.858
A0A484BYD2	A0A484DNH5	Protein kinase domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.494
A0A484BZ77	A0A484BYD2	Uncharacterized protein; Belongs to the MAGUK family.	Protein kinase domain-containing protein.	0.976
A0A484BZ77	A0A484C3T5	Uncharacterized protein; Belongs to the MAGUK family.	Protein kinase domain-containing protein.	0.979
A0A484BZ77	A0A484C4R2	Uncharacterized protein; Belongs to the MAGUK family.	Uncharacterized protein.	0.494
A0A484BZ77	A0A484CCB9	Uncharacterized protein; Belongs to the MAGUK family.	EMI domain-containing protein.	0.494
A0A484BZ77	A0A484CS61	Uncharacterized protein; Belongs to the MAGUK family.	Uncharacterized protein; Belongs to the MAGUK family.	0.858
A0A484BZ77	A0A484DNH5	Uncharacterized protein; Belongs to the MAGUK family.	ANK_REP_REGION domain-containing protein.	0.494
A0A484C222	A0A484CEB8	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	tRNA-binding domain-containing protein.	0.407
A0A484C222	A0A484CEE8	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	0.876
A0A484C222	A0A484CYH4	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Uncharacterized protein.	0.765
A0A484C222	A0A484D5X1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Uncharacterized protein.	0.780
A0A484C222	A0A484DCK6	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	0.876
A0A484C222	A0A484DFZ9	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	WD_REPEATS_REGION domain-containing protein.	0.559
A0A484C222	A0A484DHC1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	WD_REPEATS_REGION domain-containing protein.	0.558
A0A484C222	A0A484DK56	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.	0.410