(139 nodes) Mixed, incl. TNF signaling, and Toll-like receptor signaling pathway network (Lates calcarifer)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSLCAP00010000158	Uncharacterized protein. (759 aa)
	ENSLCAP00010000165	Ig-like domain-containing protein. (261 aa)
	ENSLCAP00010000166	Uncharacterized protein. (525 aa)
	ENSLCAP00010000169	Uncharacterized protein. (233 aa)
	ENSLCAP00010000170	Uncharacterized protein. (326 aa)
	LOC108894845	Uncharacterized protein. (583 aa)
	LOC108902352	TIR domain-containing protein. (821 aa)
	ENSLCAP00010001064	TNNI3 interacting kinase. (786 aa)
	ENSLCAP00010001250	Nuclear factor of activated T cells 4. (464 aa)
	ENSLCAP00010001515	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. (444 aa)
	ENSLCAP00010001624	TIR domain-containing protein. (808 aa)
	ENSLCAP00010001694	TIR domain-containing protein. (162 aa)
	otud7b	Uncharacterized protein. (927 aa)
	REL	RHD domain-containing protein. (656 aa)
	ENSLCAP00010003968	ANK_REP_REGION domain-containing protein. (691 aa)
	tab2	Uncharacterized protein. (761 aa)
	tradd	Death domain-containing protein. (293 aa)
	map3k8	Protein kinase domain-containing protein. (477 aa)
	ENSLCAP00010005490	Toll-like receptor 1; Belongs to the Toll-like receptor family. (811 aa)
	Ikbkb	Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta. (746 aa)
	nlrx1	NACHT domain-containing protein. (984 aa)
	Catip	Uncharacterized protein; Belongs to the peptidase C14A family. (459 aa)
	ENSLCAP00010008403	Uncharacterized protein; Belongs to the peptidase C14A family. (480 aa)
	LOC108895835	ANK_REP_REGION domain-containing protein. (307 aa)
	LOC108883170	TIR domain-containing protein. (878 aa)
	LOC108890753	Protein kinase domain-containing protein. (531 aa)
	LOC108890757	Uncharacterized protein. (980 aa)
	LOC108892148	Uncharacterized protein. (538 aa)
	ENSLCAP00010012586	Tumor necrosis factor receptor superfamily, member a. (419 aa)
	LOC108895804	TIR domain-containing protein; Belongs to the Toll-like receptor family. (890 aa)
	TLR8	Toll like receptor 8. (1037 aa)
	ENSLCAP00010013353	Toll-like receptor 7; Belongs to the Toll-like receptor family. (1047 aa)
	LOC108900844	RHD domain-containing protein. (603 aa)
	ENSLCAP00010013860	Si:dkey-181m9.8. (448 aa)
	ENSLCAP00010013916	Mitogen-activated protein kinase kinase kinase. (1015 aa)
	ENSLCAP00010014267	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (984 aa)
	otulin	Uncharacterized protein. (744 aa)
	ENSLCAP00010014608	TIR domain-containing protein. (165 aa)
	fas	Uncharacterized protein. (324 aa)
	tirap	TIR domain-containing protein. (267 aa)
	ENSLCAP00010016623	TNFAIP3 interacting protein 1. (547 aa)
	Tab1	TGF-beta activated kinase 1/MAP3K7 binding protein 1. (508 aa)
	ENSLCAP00010017685	CARD domain-containing protein. (123 aa)
	tollip	CUE domain-containing protein. (275 aa)
	LOC108880505	Uncharacterized protein. (195 aa)
	Sharpin	SHANK-associated RH domain interacting protein. (435 aa)
	ripk1	Uncharacterized protein. (684 aa)
	Card11	Guanylate kinase-like domain-containing protein. (281 aa)
	ENSLCAP00010020544	CARD domain-containing protein. (125 aa)
	prkcq	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (720 aa)
	ENSLCAP00010021711	V-rel avian reticuloendotheliosis viral oncogene homolog A. (625 aa)
	myd88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (292 aa)
	sigirr	Uncharacterized protein. (521 aa)
	ENSLCAP00010022551	Uncharacterized protein. (360 aa)
	setd6	N-lysine methyltransferase SETD6; Protein-lysine N-methyltransferase. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily. (490 aa)
	ENSLCAP00010023959	Mitogen-activated protein kinase kinase kinase 7. (606 aa)
	ENSLCAP00010024056	Tumor necrosis factor receptor superfamily, member 1a. (440 aa)
	ENSLCAP00010024061	DH domain-containing protein. (357 aa)
	ENSLCAP00010024823	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (365 aa)
	LOC108891446	Uncharacterized protein. (844 aa)
	LOC108900141	Uncharacterized protein. (634 aa)
	LOC108888912	Uncharacterized protein. (486 aa)
	LOC108897299	Uncharacterized protein. (762 aa)
	traf4	TNF receptor-associated factor. (470 aa)
	ENSLCAP00010026394	Sterile alpha and TIR motif containing 1. (675 aa)
	ikbke	Protein kinase domain-containing protein. (725 aa)
	ENSLCAP00010026940	Tumor necrosis factor, alpha-induced protein 3. (777 aa)
	ENSLCAP00010027290	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (278 aa)
	ENSLCAP00010027383	annotation not available (467 aa)
	mavs	CARD_2 domain-containing protein. (577 aa)
	ENSLCAP00010028440	Uncharacterized protein. (562 aa)
	ENSLCAP00010028476	Uncharacterized protein. (361 aa)
	ENSLCAP00010028487	Zmp:0000000936. (599 aa)
	LOC108891107	Protein kinase domain-containing protein. (770 aa)
	LOC108896760	Uncharacterized protein. (1121 aa)
	Mb21d1	Mab-21 domain-containing protein. (477 aa)
	ENSLCAP00010031970	Conserved helix-loop-helix ubiquitous kinase. (763 aa)
	ENSLCAP00010033183	Deoxyribonuclease; Belongs to the DNase I family. (288 aa)
	ENSLCAP00010033556	CCHC NOA-type domain-containing protein. (592 aa)
	Cyld	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family. (920 aa)
	ENSLCAP00010034930	RanBP-type and C3HC4-type zinc finger containing 1. (468 aa)
	ENSLCAP00010035387	Tax1 (human T-cell leukemia virus type I) binding protein 1a. (619 aa)
	cd48	Uncharacterized protein. (268 aa)
	MLKL	Protein kinase domain-containing protein. (474 aa)
	ENSLCAP00010036864	Protein kinase domain-containing protein. (318 aa)
	ENSLCAP00010036940	MALT paracaspase 1. (806 aa)
	irf7	IRF tryptophan pentad repeat domain-containing protein. (441 aa)
	LOC108885749	Uncharacterized protein. (634 aa)
	ENSLCAP00010037926	Protein kinase domain-containing protein. (777 aa)
	irak3	Uncharacterized protein. (598 aa)
	nfkb2	Uncharacterized protein. (903 aa)
	traf6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (609 aa)
	nod1	Uncharacterized protein. (939 aa)
	ENSLCAP00010041012	Interleukin-1. (240 aa)
	nfkbie	ANK_REP_REGION domain-containing protein. (349 aa)
	TLR2	Toll like receptor 2. (689 aa)
	ENSLCAP00010041447	Mitogen-activated protein kinase kinase kinase. (1000 aa)
	tlr3	TIR domain-containing protein; Belongs to the Toll-like receptor family. (922 aa)
	LOC108885597	Uncharacterized protein. (712 aa)
	il1rap	Uncharacterized protein. (652 aa)
	ENSLCAP00010042514	Protein kinase domain-containing protein. (427 aa)
	spata2l	Uncharacterized protein. (566 aa)
	ENSLCAP00010043312	Uncharacterized protein. (107 aa)
	tbk1	Uncharacterized protein. (723 aa)
	Zranb1	Zinc finger, RAN-binding domain containing 1a. (708 aa)
	ENSLCAP00010046779	Cylindromatosis (turban tumor syndrome), like; Belongs to the peptidase C19 family. (520 aa)
	spata2	Uncharacterized protein. (568 aa)
	LOC108894452	Uncharacterized protein. (710 aa)
	ENSLCAP00010047823	Uncharacterized protein. (546 aa)
	nfkbia	ANK_REP_REGION domain-containing protein. (319 aa)
	ENSLCAP00010048326	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (639 aa)
	ENSLCAP00010048398	Non-specific serine/threonine protein kinase. (290 aa)
	ENSLCAP00010048403	Phorbol-ester/DAG-type domain-containing protein. (215 aa)
	cflar	Uncharacterized protein; Belongs to the peptidase C14A family. (516 aa)
	ENSLCAP00010049200	Mitogen-activated protein kinase kinase kinase. (898 aa)
	ENSLCAP00010049495	TIR domain-containing protein. (857 aa)
	ENSLCAP00010049506	TIR domain-containing protein. (641 aa)
	tab3	Uncharacterized protein. (616 aa)
	LOC108885865	TIR domain-containing protein. (821 aa)
	ENSLCAP00010050445	NEMO domain-containing protein. (371 aa)
	PDZRN4	PDZ domain-containing protein. (763 aa)
	LOC108878374	Interleukin-1. (278 aa)
	irak4	Protein kinase domain-containing protein. (458 aa)
	ripk2	Uncharacterized protein. (603 aa)
	ENSLCAP00010052120	Ig-like domain-containing protein. (474 aa)
	sting1	Uncharacterized protein. (409 aa)
	ENSLCAP00010053450	RING-type domain-containing protein. (609 aa)
	tank	TBD domain-containing protein. (534 aa)
	plekhg5	Uncharacterized protein. (1175 aa)
	LOC108876980	IRF tryptophan pentad repeat domain-containing protein. (263 aa)
	Pdzrn3	PDZ domain containing RING finger 3b. (1025 aa)
	ENSLCAP00010055806	Uncharacterized protein. (802 aa)
	il1r2	Uncharacterized protein. (423 aa)
	LOC108874758	Endo/exonuclease/phosphatase domain-containing protein. (328 aa)
	ENSLCAP00010058119	MALT paracaspase 2. (565 aa)
	ENSLCAP00010058335	Uncharacterized protein. (341 aa)
	LOC108878507	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (566 aa)
	LOC108884442	IRF tryptophan pentad repeat domain-containing protein. (466 aa)
	ENSLCAP00010059112	Caspase 8, apoptosis-related cysteine peptidase, like 2; Belongs to the peptidase C14A family. (647 aa)

Your Current Organism:

Lates calcarifer

NCBI taxonomy Id: 8187
Other names: Asian seabass, Holocentrus calcarifer, L. calcarifer, barramundi, barramundi perch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Card11	ENSLCAP00010001515	ENSLCAP00010020526	ENSLCAP00010001515	Guanylate kinase-like domain-containing protein.	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily.	0.663
Card11	ENSLCAP00010020544	ENSLCAP00010020526	ENSLCAP00010020544	Guanylate kinase-like domain-containing protein.	CARD domain-containing protein.	0.900
Card11	ENSLCAP00010023959	ENSLCAP00010020526	ENSLCAP00010023959	Guanylate kinase-like domain-containing protein.	Mitogen-activated protein kinase kinase kinase 7.	0.663
Card11	ENSLCAP00010026940	ENSLCAP00010020526	ENSLCAP00010026940	Guanylate kinase-like domain-containing protein.	Tumor necrosis factor, alpha-induced protein 3.	0.415
Card11	ENSLCAP00010031970	ENSLCAP00010020526	ENSLCAP00010031970	Guanylate kinase-like domain-containing protein.	Conserved helix-loop-helix ubiquitous kinase.	0.569
Card11	ENSLCAP00010036940	ENSLCAP00010020526	ENSLCAP00010036940	Guanylate kinase-like domain-containing protein.	MALT paracaspase 1.	0.817
Card11	ENSLCAP00010042514	ENSLCAP00010020526	ENSLCAP00010042514	Guanylate kinase-like domain-containing protein.	Protein kinase domain-containing protein.	0.536
Card11	ENSLCAP00010048398	ENSLCAP00010020526	ENSLCAP00010048398	Guanylate kinase-like domain-containing protein.	Non-specific serine/threonine protein kinase.	0.696
Card11	ENSLCAP00010048403	ENSLCAP00010020526	ENSLCAP00010048403	Guanylate kinase-like domain-containing protein.	Phorbol-ester/DAG-type domain-containing protein.	0.696
Card11	ENSLCAP00010050445	ENSLCAP00010020526	ENSLCAP00010050445	Guanylate kinase-like domain-containing protein.	NEMO domain-containing protein.	0.769
Card11	ENSLCAP00010055806	ENSLCAP00010020526	ENSLCAP00010055806	Guanylate kinase-like domain-containing protein.	Uncharacterized protein.	0.536
Card11	ENSLCAP00010058119	ENSLCAP00010020526	ENSLCAP00010058119	Guanylate kinase-like domain-containing protein.	MALT paracaspase 2.	0.817
Card11	Ikbkb	ENSLCAP00010020526	ENSLCAP00010005949	Guanylate kinase-like domain-containing protein.	Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta.	0.628
Card11	LOC108891107	ENSLCAP00010020526	ENSLCAP00010028815	Guanylate kinase-like domain-containing protein.	Protein kinase domain-containing protein.	0.628
Card11	LOC108895835	ENSLCAP00010020526	ENSLCAP00010008843	Guanylate kinase-like domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.470
Card11	nfkbia	ENSLCAP00010020526	ENSLCAP00010048180	Guanylate kinase-like domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.470
Card11	prkcq	ENSLCAP00010020526	ENSLCAP00010021081	Guanylate kinase-like domain-containing protein.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.676
Card11	ripk2	ENSLCAP00010020526	ENSLCAP00010051481	Guanylate kinase-like domain-containing protein.	Uncharacterized protein.	0.485
Card11	tab2	ENSLCAP00010020526	ENSLCAP00010004220	Guanylate kinase-like domain-containing protein.	Uncharacterized protein.	0.455
Card11	tab3	ENSLCAP00010020526	ENSLCAP00010049860	Guanylate kinase-like domain-containing protein.	Uncharacterized protein.	0.490