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| | Cdt1 | Chromatin licensing and DNA replication factor 1. (482 aa) |
| | pms1 | HMG box domain-containing protein. (919 aa) |
| | Pold1 | DNA polymerase. (1098 aa) |
| | mad2l2 | HORMA domain-containing protein. (210 aa) |
| | dmc1 | Uncharacterized protein; Belongs to the RecA family. (342 aa) |
| | Ercc4 | Excision repair cross-complementation group 4. (889 aa) |
| | Rfc1 | Replication factor C subunit 1. (1148 aa) |
| | ENSLCAP00010002675 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (556 aa) |
| | recql5 | Uncharacterized protein. (1020 aa) |
| | LOC108875967 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (606 aa) |
| | dbf4 | Uncharacterized protein. (628 aa) |
| | ENSLCAP00010004003 | REV3-like, polymerase (DNA directed), zeta, catalytic subunit. (2860 aa) |
| | mphosph9 | Uncharacterized protein. (1287 aa) |
| | lig1 | DNA ligase. (1015 aa) |
| | ENSLCAP00010005350 | Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (806 aa) |
| | rhno1 | Uncharacterized protein. (300 aa) |
| | Rmi2 | RecQ mediated genome instability 2. (91 aa) |
| | LOC108898738 | DBF4-type domain-containing protein. (841 aa) |
| | brca1 | Uncharacterized protein. (1411 aa) |
| | ENSLCAP00010006345 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (869 aa) |
| | Rbbp8 | SAE2 domain-containing protein. (73 aa) |
| | ENSLCAP00010006661 | Piezo-type mechanosensitive ion channel component. (2201 aa) |
| | ENSLCAP00010006675 | Uncharacterized protein. (176 aa) |
| | Orc5 | Origin recognition complex, subunit 5. (449 aa) |
| | cdc45 | Uncharacterized protein. (568 aa) |
| | pold3 | Uncharacterized protein. (446 aa) |
| | gins2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (186 aa) |
| | pcna | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa) |
| | pola2 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (602 aa) |
| | ENSLCAP00010008081 | Tumor protein p53 binding protein, 1. (1495 aa) |
| | ENSLCAP00010008183 | RecQ helicase-like 4. (1236 aa) |
| | Msh3 | MutS homolog 3 (E. coli); Component of the post-replicative DNA mismatch repair system (MMR). (1004 aa) |
| | mcm6 | DNA helicase; Belongs to the MCM family. (832 aa) |
| | ENSLCAP00010008769 | Origin recognition complex, subunit 2. (534 aa) |
| | pole3 | CBFD_NFYB_HMF domain-containing protein. (149 aa) |
| | tipin | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (302 aa) |
| | dscc1 | Uncharacterized protein. (390 aa) |
| | blm | Uncharacterized protein. (1413 aa) |
| | Rad1 | RAD1 homolog (S. pombe). (329 aa) |
| | mcm4 | DNA helicase; Belongs to the MCM family. (860 aa) |
| | ENSLCAP00010011268 | MutS homolog 5. (799 aa) |
| | cdh17 | Uncharacterized protein. (937 aa) |
| | mcm3 | DNA helicase; Belongs to the MCM family. (815 aa) |
| | ENSLCAP00010011831 | DNA polymerase. (1466 aa) |
| | rpa3 | Uncharacterized protein. (122 aa) |
| | Pms2 | PMS1 homolog 2, mismatch repair system component. (861 aa) |
| | ENSLCAP00010013661 | RAD54 like. (723 aa) |
| | Rev1 | DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1013 aa) |
| | stn1 | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (382 aa) |
| | rad51d | RECA_2 domain-containing protein. (334 aa) |
| | hus1 | Checkpoint protein; Belongs to the HUS1 family. (285 aa) |
| | rad54l | Uncharacterized protein. (740 aa) |
| | Mcmbp | Minichromosome maintenance complex binding protein. (636 aa) |
| | LOC108883334 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (940 aa) |
| | gins3 | Sld5 domain-containing protein. (211 aa) |
| | tdrd3 | Uncharacterized protein. (785 aa) |
| | xpa | XPA_C domain-containing protein. (340 aa) |
| | fen1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | chek1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (486 aa) |
| | Rfc2 | Replication factor C (activator 1) 2. (444 aa) |
| | exd2 | 3'-5' exonuclease domain-containing protein. (639 aa) |
| | ercc5 | Uncharacterized protein. (1138 aa) |
| | Top3a | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1041 aa) |
| | rad9a | Cell cycle checkpoint control protein; Belongs to the rad9 family. (393 aa) |
| | polh | UmuC domain-containing protein. (738 aa) |
| | mcm2 | DNA helicase; Belongs to the MCM family. (916 aa) |
| | rpa2 | RPA_C domain-containing protein. (290 aa) |
| | rad51b | RECA_2 domain-containing protein. (386 aa) |
| | cdca7l | zf-4CXXC_R1 domain-containing protein. (417 aa) |
| | ENSLCAP00010027006 | Basic, immunoglobulin-like variable motif containing. (473 aa) |
| | ENSLCAP00010027048 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (314 aa) |
| | mcm9 | MCM domain-containing protein; Belongs to the MCM family. (1238 aa) |
| | MCMDC2 | MCM_lid domain-containing protein. (678 aa) |
| | Orc4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (462 aa) |
| | ENSLCAP00010029188 | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2552 aa) |
| | gmnn | Uncharacterized protein. (234 aa) |
| | ENSLCAP00010029854 | ATPase family, AAA domain containing 5a. (1490 aa) |
| | Brca2 | Breast cancer 2, early onset. (2872 aa) |
| | rad52 | Uncharacterized protein. (435 aa) |
| | ENSLCAP00010031718 | DNA topoisomerase II binding protein 1. (1435 aa) |
| | ENSLCAP00010032855 | RAD17 checkpoint clamp loader component. (467 aa) |
| | LOC108900468 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1108 aa) |
| | ENSLCAP00010034255 | Exonuclease 1. (607 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (217 aa) |
| | Rfc5 | AAA domain-containing protein. (350 aa) |
| | Mre11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (666 aa) |
| | ENSLCAP00010036720 | UmuC domain-containing protein. (598 aa) |
| | Xrcc3 | X-ray repair complementing defective repair in Chinese hamster cells 3. (342 aa) |
| | wdhd1 | Uncharacterized protein. (1130 aa) |
| | atrip | Uncharacterized protein. (873 aa) |
| | rad51c | RECA_2 domain-containing protein. (381 aa) |
| | Msh2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (908 aa) |
| | Pole2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (513 aa) |
| | prim1 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (424 aa) |
| | Mlh3 | MutL homolog 3 (E. coli). (1177 aa) |
| | Cdca7l | Cell division cycle associated 7b. (416 aa) |
| | LOC108880436 | Uncharacterized protein. (814 aa) |
| | ten1 | Uncharacterized protein. (124 aa) |
| | rad50 | Zinc-hook domain-containing protein. (1313 aa) |
| | ercc1 | Uncharacterized protein. (360 aa) |
| | timeless | Uncharacterized protein. (1251 aa) |
| | Msh6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1241 aa) |
| | gins1 | Sld5 domain-containing protein. (196 aa) |
| | chtf8 | Uncharacterized protein. (198 aa) |
| | mcm5 | DNA helicase; Belongs to the MCM family. (737 aa) |
| | Orc3 | Origin recognition complex, subunit 3. (712 aa) |
| | msh4 | DNA_MISMATCH_REPAIR_2 domain-containing protein. (925 aa) |
| | mcm10 | Mcm10 domain-containing protein. (908 aa) |
| | ENSLCAP00010047538 | F-box domain-containing protein. (743 aa) |
| | fbh1 | F-box domain-containing protein. (1078 aa) |
| | mcm7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (729 aa) |
| | pif1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (632 aa) |
| | Mlh1 | MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (716 aa) |
| | cdc7 | Protein kinase domain-containing protein. (610 aa) |
| | rfc3 | AAA domain-containing protein. (356 aa) |
| | ENSLCAP00010050488 | Zgc:110269. (339 aa) |
| | ENSLCAP00010051639 | Uncharacterized protein. (521 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (678 aa) |
| | top3b | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (858 aa) |
| | pold2 | Uncharacterized protein. (471 aa) |
| | pold4 | Uncharacterized protein. (108 aa) |
| | rfc4 | AAA domain-containing protein. (357 aa) |
| | Cdca7 | Cell division cycle associated 7a. (391 aa) |
| | chtf18 | AAA domain-containing protein. (921 aa) |
| | Dna2 | DNA replication helicase/nuclease 2. (1408 aa) |
| | pole4 | CBFD_NFYB_HMF domain-containing protein. (129 aa) |
| | LOC108881387 | SCY domain-containing protein. (125 aa) |
| | gins4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (224 aa) |
| | rad9b | Uncharacterized protein. (328 aa) |
| | Prim2 | DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (502 aa) |
| | Slf1 | SMC5-SMC6 complex localization factor 1. (752 aa) |
| | polk | UmuC domain-containing protein. (887 aa) |
| | meiob | Uncharacterized protein. (460 aa) |
| | pole | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2296 aa) |
| | rmi1 | DUF1767 domain-containing protein. (700 aa) |
