STRINGSTRING
Cdt1 Cdt1 Pold1 Pold1 mad2l2 mad2l2 Rfc1 Rfc1 ENSLCAP00010002675 ENSLCAP00010002675 dbf4 dbf4 ENSLCAP00010004003 ENSLCAP00010004003 lig1 lig1 ENSLCAP00010005350 ENSLCAP00010005350 LOC108898738 LOC108898738 ENSLCAP00010006345 ENSLCAP00010006345 ENSLCAP00010006661 ENSLCAP00010006661 Orc5 Orc5 cdc45 cdc45 pold3 pold3 gins2 gins2 pcna pcna pola2 pola2 mcm6 mcm6 ENSLCAP00010008769 ENSLCAP00010008769 pole3 pole3 tipin tipin dscc1 dscc1 mcm4 mcm4 mcm3 mcm3 ENSLCAP00010011831 ENSLCAP00010011831 Rev1 Rev1 stn1 stn1 Mcmbp Mcmbp LOC108883334 LOC108883334 gins3 gins3 fen1 fen1 Rfc2 Rfc2 polh polh mcm2 mcm2 mcm9 mcm9 MCMDC2 MCMDC2 Orc4 Orc4 gmnn gmnn ENSLCAP00010029854 ENSLCAP00010029854 ENSLCAP00010032855 ENSLCAP00010032855 Rfc5 Rfc5 ENSLCAP00010036720 ENSLCAP00010036720 wdhd1 wdhd1 Pole2 Pole2 prim1 prim1 ten1 ten1 timeless timeless gins1 gins1 chtf8 chtf8 mcm5 mcm5 Orc3 Orc3 mcm10 mcm10 mcm7 mcm7 cdc7 cdc7 rfc3 rfc3 ENSLCAP00010050488 ENSLCAP00010050488 ENSLCAP00010051639 ENSLCAP00010051639 pold2 pold2 pold4 pold4 rfc4 rfc4 chtf18 chtf18 pole4 pole4 LOC108881387 LOC108881387 gins4 gins4 Prim2 Prim2 polk polk pole pole
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Cdt1Chromatin licensing and DNA replication factor 1. (482 aa)
Pold1DNA polymerase. (1098 aa)
mad2l2HORMA domain-containing protein. (210 aa)
Rfc1Replication factor C subunit 1. (1148 aa)
ENSLCAP00010002675Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (556 aa)
dbf4Uncharacterized protein. (628 aa)
ENSLCAP00010004003REV3-like, polymerase (DNA directed), zeta, catalytic subunit. (2860 aa)
lig1DNA ligase. (1015 aa)
ENSLCAP00010005350Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (806 aa)
LOC108898738DBF4-type domain-containing protein. (841 aa)
ENSLCAP00010006345Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (869 aa)
ENSLCAP00010006661Piezo-type mechanosensitive ion channel component. (2201 aa)
Orc5Origin recognition complex, subunit 5. (449 aa)
cdc45Uncharacterized protein. (568 aa)
pold3Uncharacterized protein. (446 aa)
gins2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (186 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (602 aa)
mcm6DNA helicase; Belongs to the MCM family. (832 aa)
ENSLCAP00010008769Origin recognition complex, subunit 2. (534 aa)
pole3CBFD_NFYB_HMF domain-containing protein. (149 aa)
tipinTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (302 aa)
dscc1Uncharacterized protein. (390 aa)
mcm4DNA helicase; Belongs to the MCM family. (860 aa)
mcm3DNA helicase; Belongs to the MCM family. (815 aa)
ENSLCAP00010011831DNA polymerase. (1466 aa)
Rev1DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1013 aa)
stn1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (382 aa)
McmbpMinichromosome maintenance complex binding protein. (636 aa)
LOC108883334Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (940 aa)
gins3Sld5 domain-containing protein. (211 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
Rfc2Replication factor C (activator 1) 2. (444 aa)
polhUmuC domain-containing protein. (738 aa)
mcm2DNA helicase; Belongs to the MCM family. (916 aa)
mcm9MCM domain-containing protein; Belongs to the MCM family. (1238 aa)
MCMDC2MCM_lid domain-containing protein. (678 aa)
Orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (462 aa)
gmnnUncharacterized protein. (234 aa)
ENSLCAP00010029854ATPase family, AAA domain containing 5a. (1490 aa)
ENSLCAP00010032855RAD17 checkpoint clamp loader component. (467 aa)
Rfc5AAA domain-containing protein. (350 aa)
ENSLCAP00010036720UmuC domain-containing protein. (598 aa)
wdhd1Uncharacterized protein. (1130 aa)
Pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (513 aa)
prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (424 aa)
ten1Uncharacterized protein. (124 aa)
timelessUncharacterized protein. (1251 aa)
gins1Sld5 domain-containing protein. (196 aa)
chtf8Uncharacterized protein. (198 aa)
mcm5DNA helicase; Belongs to the MCM family. (737 aa)
Orc3Origin recognition complex, subunit 3. (712 aa)
mcm10Mcm10 domain-containing protein. (908 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (729 aa)
cdc7Protein kinase domain-containing protein. (610 aa)
rfc3AAA domain-containing protein. (356 aa)
ENSLCAP00010050488Zgc:110269. (339 aa)
ENSLCAP00010051639Uncharacterized protein. (521 aa)
pold2Uncharacterized protein. (471 aa)
pold4Uncharacterized protein. (108 aa)
rfc4AAA domain-containing protein. (357 aa)
chtf18AAA domain-containing protein. (921 aa)
pole4CBFD_NFYB_HMF domain-containing protein. (129 aa)
LOC108881387SCY domain-containing protein. (125 aa)
gins4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (224 aa)
Prim2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (502 aa)
polkUmuC domain-containing protein. (887 aa)
poleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2296 aa)
Your Current Organism:
Lates calcarifer
NCBI taxonomy Id: 8187
Other names: Asian seabass, Holocentrus calcarifer, L. calcarifer, barramundi, barramundi perch
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