(45 nodes) HDR through Single Strand Annealing (SSA), and DNA recombination and repair protein Rad51-like, C-terminal network (Lates calcarifer)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	dmc1	Uncharacterized protein; Belongs to the RecA family. (342 aa)
	recql5	Uncharacterized protein. (1020 aa)
	LOC108875967	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (606 aa)
	rhno1	Uncharacterized protein. (300 aa)
	Rmi2	RecQ mediated genome instability 2. (91 aa)
	brca1	Uncharacterized protein. (1411 aa)
	Rbbp8	SAE2 domain-containing protein. (73 aa)
	ENSLCAP00010006675	Uncharacterized protein. (176 aa)
	ENSLCAP00010008081	Tumor protein p53 binding protein, 1. (1495 aa)
	ENSLCAP00010008183	RecQ helicase-like 4. (1236 aa)
	blm	Uncharacterized protein. (1413 aa)
	Rad1	RAD1 homolog (S. pombe). (329 aa)
	rpa3	Uncharacterized protein. (122 aa)
	rad51d	RECA_2 domain-containing protein. (334 aa)
	hus1	Checkpoint protein; Belongs to the HUS1 family. (285 aa)
	tdrd3	Uncharacterized protein. (785 aa)
	chek1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (486 aa)
	exd2	3'-5' exonuclease domain-containing protein. (639 aa)
	Top3a	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1041 aa)
	rad9a	Cell cycle checkpoint control protein; Belongs to the rad9 family. (393 aa)
	rpa2	RPA_C domain-containing protein. (290 aa)
	rad51b	RECA_2 domain-containing protein. (386 aa)
	ENSLCAP00010027048	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (314 aa)
	ENSLCAP00010029188	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2552 aa)
	Brca2	Breast cancer 2, early onset. (2872 aa)
	rad52	Uncharacterized protein. (435 aa)
	ENSLCAP00010031718	DNA topoisomerase II binding protein 1. (1435 aa)
	LOC108900468	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1108 aa)
	ENSLCAP00010034255	Exonuclease 1. (607 aa)
	XRCC2	X-ray repair cross complementing 2. (217 aa)
	Mre11	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (666 aa)
	Xrcc3	X-ray repair complementing defective repair in Chinese hamster cells 3. (342 aa)
	atrip	Uncharacterized protein. (873 aa)
	rad51c	RECA_2 domain-containing protein. (381 aa)
	LOC108880436	Uncharacterized protein. (814 aa)
	rad50	Zinc-hook domain-containing protein. (1313 aa)
	fbh1	F-box domain-containing protein. (1078 aa)
	pif1	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (632 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (678 aa)
	top3b	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (858 aa)
	Dna2	DNA replication helicase/nuclease 2. (1408 aa)
	rad9b	Uncharacterized protein. (328 aa)
	Slf1	SMC5-SMC6 complex localization factor 1. (752 aa)
	meiob	Uncharacterized protein. (460 aa)
	rmi1	DUF1767 domain-containing protein. (700 aa)

Your Current Organism:

Lates calcarifer

NCBI taxonomy Id: 8187
Other names: Asian seabass, Holocentrus calcarifer, L. calcarifer, barramundi, barramundi perch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Brca2	Dna2	ENSLCAP00010030231	ENSLCAP00010056294	Breast cancer 2, early onset.	DNA replication helicase/nuclease 2.	0.902
Brca2	ENSLCAP00010006675	ENSLCAP00010030231	ENSLCAP00010006675	Breast cancer 2, early onset.	Uncharacterized protein.	0.473
Brca2	ENSLCAP00010008081	ENSLCAP00010030231	ENSLCAP00010008081	Breast cancer 2, early onset.	Tumor protein p53 binding protein, 1.	0.603
Brca2	ENSLCAP00010008183	ENSLCAP00010030231	ENSLCAP00010008183	Breast cancer 2, early onset.	RecQ helicase-like 4.	0.798
Brca2	ENSLCAP00010027048	ENSLCAP00010030231	ENSLCAP00010027048	Breast cancer 2, early onset.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.999
Brca2	ENSLCAP00010029188	ENSLCAP00010030231	ENSLCAP00010029188	Breast cancer 2, early onset.	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.597
Brca2	ENSLCAP00010031718	ENSLCAP00010030231	ENSLCAP00010031718	Breast cancer 2, early onset.	DNA topoisomerase II binding protein 1.	0.712
Brca2	ENSLCAP00010034255	ENSLCAP00010030231	ENSLCAP00010034255	Breast cancer 2, early onset.	Exonuclease 1.	0.921
Brca2	LOC108875967	ENSLCAP00010030231	ENSLCAP00010003251	Breast cancer 2, early onset.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.621
Brca2	LOC108880436	ENSLCAP00010030231	ENSLCAP00010043080	Breast cancer 2, early onset.	Uncharacterized protein.	0.976
Brca2	LOC108900468	ENSLCAP00010030231	ENSLCAP00010033459	Breast cancer 2, early onset.	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	0.742
Brca2	Mre11	ENSLCAP00010030231	ENSLCAP00010035359	Breast cancer 2, early onset.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.885
Brca2	RPA1	ENSLCAP00010030231	ENSLCAP00010051821	Breast cancer 2, early onset.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.621
Brca2	Rbbp8	ENSLCAP00010030231	ENSLCAP00010006577	Breast cancer 2, early onset.	SAE2 domain-containing protein.	0.862
Brca2	Rmi2	ENSLCAP00010030231	ENSLCAP00010005819	Breast cancer 2, early onset.	RecQ mediated genome instability 2.	0.685
Brca2	Slf1	ENSLCAP00010030231	ENSLCAP00010059864	Breast cancer 2, early onset.	SMC5-SMC6 complex localization factor 1.	0.757
Brca2	Top3a	ENSLCAP00010030231	ENSLCAP00010023203	Breast cancer 2, early onset.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.842
Brca2	XRCC2	ENSLCAP00010030231	ENSLCAP00010034447	Breast cancer 2, early onset.	X-ray repair cross complementing 2.	0.908
Brca2	Xrcc3	ENSLCAP00010030231	ENSLCAP00010037345	Breast cancer 2, early onset.	X-ray repair complementing defective repair in Chinese hamster cells 3.	0.978
Brca2	atrip	ENSLCAP00010030231	ENSLCAP00010037873	Breast cancer 2, early onset.	Uncharacterized protein.	0.613