(22 nodes) Homologous DNA Pairing and Strand Exchange, and ATR-ATRIP complex network (Lates calcarifer)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	dmc1	Uncharacterized protein; Belongs to the RecA family. (342 aa)
	brca1	Uncharacterized protein. (1411 aa)
	Rbbp8	SAE2 domain-containing protein. (73 aa)
	ENSLCAP00010008081	Tumor protein p53 binding protein, 1. (1495 aa)
	ENSLCAP00010008183	RecQ helicase-like 4. (1236 aa)
	rad51d	RECA_2 domain-containing protein. (334 aa)
	chek1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (486 aa)
	rad51b	RECA_2 domain-containing protein. (386 aa)
	ENSLCAP00010027048	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (314 aa)
	ENSLCAP00010029188	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2552 aa)
	Brca2	Breast cancer 2, early onset. (2872 aa)
	ENSLCAP00010031718	DNA topoisomerase II binding protein 1. (1435 aa)
	ENSLCAP00010034255	Exonuclease 1. (607 aa)
	XRCC2	X-ray repair cross complementing 2. (217 aa)
	Mre11	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (666 aa)
	Xrcc3	X-ray repair complementing defective repair in Chinese hamster cells 3. (342 aa)
	atrip	Uncharacterized protein. (873 aa)
	rad51c	RECA_2 domain-containing protein. (381 aa)
	LOC108880436	Uncharacterized protein. (814 aa)
	rad50	Zinc-hook domain-containing protein. (1313 aa)
	Dna2	DNA replication helicase/nuclease 2. (1408 aa)
	meiob	Uncharacterized protein. (460 aa)

Your Current Organism:

Lates calcarifer

NCBI taxonomy Id: 8187
Other names: Asian seabass, Holocentrus calcarifer, L. calcarifer, barramundi, barramundi perch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Brca2	Dna2	ENSLCAP00010030231	ENSLCAP00010056294	Breast cancer 2, early onset.	DNA replication helicase/nuclease 2.	0.902
Brca2	ENSLCAP00010008081	ENSLCAP00010030231	ENSLCAP00010008081	Breast cancer 2, early onset.	Tumor protein p53 binding protein, 1.	0.603
Brca2	ENSLCAP00010008183	ENSLCAP00010030231	ENSLCAP00010008183	Breast cancer 2, early onset.	RecQ helicase-like 4.	0.798
Brca2	ENSLCAP00010027048	ENSLCAP00010030231	ENSLCAP00010027048	Breast cancer 2, early onset.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.999
Brca2	ENSLCAP00010029188	ENSLCAP00010030231	ENSLCAP00010029188	Breast cancer 2, early onset.	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.597
Brca2	ENSLCAP00010031718	ENSLCAP00010030231	ENSLCAP00010031718	Breast cancer 2, early onset.	DNA topoisomerase II binding protein 1.	0.712
Brca2	ENSLCAP00010034255	ENSLCAP00010030231	ENSLCAP00010034255	Breast cancer 2, early onset.	Exonuclease 1.	0.921
Brca2	LOC108880436	ENSLCAP00010030231	ENSLCAP00010043080	Breast cancer 2, early onset.	Uncharacterized protein.	0.976
Brca2	Mre11	ENSLCAP00010030231	ENSLCAP00010035359	Breast cancer 2, early onset.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.885
Brca2	Rbbp8	ENSLCAP00010030231	ENSLCAP00010006577	Breast cancer 2, early onset.	SAE2 domain-containing protein.	0.862
Brca2	XRCC2	ENSLCAP00010030231	ENSLCAP00010034447	Breast cancer 2, early onset.	X-ray repair cross complementing 2.	0.908
Brca2	Xrcc3	ENSLCAP00010030231	ENSLCAP00010037345	Breast cancer 2, early onset.	X-ray repair complementing defective repair in Chinese hamster cells 3.	0.978
Brca2	atrip	ENSLCAP00010030231	ENSLCAP00010037873	Breast cancer 2, early onset.	Uncharacterized protein.	0.613
Brca2	brca1	ENSLCAP00010030231	ENSLCAP00010006276	Breast cancer 2, early onset.	Uncharacterized protein.	0.999
Brca2	chek1	ENSLCAP00010030231	ENSLCAP00010020211	Breast cancer 2, early onset.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.707
Brca2	dmc1	ENSLCAP00010030231	ENSLCAP00010001278	Breast cancer 2, early onset.	Uncharacterized protein; Belongs to the RecA family.	0.945
Brca2	meiob	ENSLCAP00010030231	ENSLCAP00010060389	Breast cancer 2, early onset.	Uncharacterized protein.	0.683
Brca2	rad50	ENSLCAP00010030231	ENSLCAP00010043215	Breast cancer 2, early onset.	Zinc-hook domain-containing protein.	0.666
Brca2	rad51b	ENSLCAP00010030231	ENSLCAP00010025561	Breast cancer 2, early onset.	RECA_2 domain-containing protein.	0.965
Brca2	rad51c	ENSLCAP00010030231	ENSLCAP00010038365	Breast cancer 2, early onset.	RECA_2 domain-containing protein.	0.997