(11 nodes) Presynaptic phase of homologous DNA pairing and strand exchange, and Ubiquitin modification-dependent histone binding network (Lates calcarifer)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	brca1	Uncharacterized protein. (1411 aa)
	Rbbp8	SAE2 domain-containing protein. (73 aa)
	ENSLCAP00010008081	Tumor protein p53 binding protein, 1. (1495 aa)
	ENSLCAP00010008183	RecQ helicase-like 4. (1236 aa)
	chek1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (486 aa)
	ENSLCAP00010031718	DNA topoisomerase II binding protein 1. (1435 aa)
	ENSLCAP00010034255	Exonuclease 1. (607 aa)
	Mre11	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (666 aa)
	LOC108880436	Uncharacterized protein. (814 aa)
	rad50	Zinc-hook domain-containing protein. (1313 aa)
	Dna2	DNA replication helicase/nuclease 2. (1408 aa)

Your Current Organism:

Lates calcarifer

NCBI taxonomy Id: 8187
Other names: Asian seabass, Holocentrus calcarifer, L. calcarifer, barramundi, barramundi perch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Dna2	ENSLCAP00010008081	ENSLCAP00010056294	ENSLCAP00010008081	DNA replication helicase/nuclease 2.	Tumor protein p53 binding protein, 1.	0.839
Dna2	ENSLCAP00010008183	ENSLCAP00010056294	ENSLCAP00010008183	DNA replication helicase/nuclease 2.	RecQ helicase-like 4.	0.952
Dna2	ENSLCAP00010031718	ENSLCAP00010056294	ENSLCAP00010031718	DNA replication helicase/nuclease 2.	DNA topoisomerase II binding protein 1.	0.915
Dna2	ENSLCAP00010034255	ENSLCAP00010056294	ENSLCAP00010034255	DNA replication helicase/nuclease 2.	Exonuclease 1.	0.988
Dna2	LOC108880436	ENSLCAP00010056294	ENSLCAP00010043080	DNA replication helicase/nuclease 2.	Uncharacterized protein.	0.790
Dna2	Mre11	ENSLCAP00010056294	ENSLCAP00010035359	DNA replication helicase/nuclease 2.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.931
Dna2	Rbbp8	ENSLCAP00010056294	ENSLCAP00010006577	DNA replication helicase/nuclease 2.	SAE2 domain-containing protein.	0.870
Dna2	brca1	ENSLCAP00010056294	ENSLCAP00010006276	DNA replication helicase/nuclease 2.	Uncharacterized protein.	0.896
Dna2	chek1	ENSLCAP00010056294	ENSLCAP00010020211	DNA replication helicase/nuclease 2.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.833
Dna2	rad50	ENSLCAP00010056294	ENSLCAP00010043215	DNA replication helicase/nuclease 2.	Zinc-hook domain-containing protein.	0.777
ENSLCAP00010008081	Dna2	ENSLCAP00010008081	ENSLCAP00010056294	Tumor protein p53 binding protein, 1.	DNA replication helicase/nuclease 2.	0.839
ENSLCAP00010008081	ENSLCAP00010008183	ENSLCAP00010008081	ENSLCAP00010008183	Tumor protein p53 binding protein, 1.	RecQ helicase-like 4.	0.900
ENSLCAP00010008081	ENSLCAP00010031718	ENSLCAP00010008081	ENSLCAP00010031718	Tumor protein p53 binding protein, 1.	DNA topoisomerase II binding protein 1.	0.993
ENSLCAP00010008081	ENSLCAP00010034255	ENSLCAP00010008081	ENSLCAP00010034255	Tumor protein p53 binding protein, 1.	Exonuclease 1.	0.879
ENSLCAP00010008081	LOC108880436	ENSLCAP00010008081	ENSLCAP00010043080	Tumor protein p53 binding protein, 1.	Uncharacterized protein.	0.877
ENSLCAP00010008081	Mre11	ENSLCAP00010008081	ENSLCAP00010035359	Tumor protein p53 binding protein, 1.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.914
ENSLCAP00010008081	Rbbp8	ENSLCAP00010008081	ENSLCAP00010006577	Tumor protein p53 binding protein, 1.	SAE2 domain-containing protein.	0.696
ENSLCAP00010008081	brca1	ENSLCAP00010008081	ENSLCAP00010006276	Tumor protein p53 binding protein, 1.	Uncharacterized protein.	0.950
ENSLCAP00010008081	chek1	ENSLCAP00010008081	ENSLCAP00010020211	Tumor protein p53 binding protein, 1.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.954
ENSLCAP00010008081	rad50	ENSLCAP00010008081	ENSLCAP00010043215	Tumor protein p53 binding protein, 1.	Zinc-hook domain-containing protein.	0.762