(36 nodes) Cardiac ventricle morphogenesis network (Lates calcarifer)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSLCAP00010041081	Uncharacterized protein. (206 aa)
	ENSLCAP00010041660	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family. (446 aa)
	TNNC1	Uncharacterized protein. (161 aa)
	Sfrp2	Secreted frizzled-related protein 2. (284 aa)
	ENSLCAP00010041994	Neuropeptide Y receptor Y2; Belongs to the G-protein coupled receptor 1 family. (332 aa)
	LOC108876301	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (591 aa)
	LOC108886611	Uncharacterized protein. (389 aa)
	ENSLCAP00010047727	Endothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family. (458 aa)
	EDNRA	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (474 aa)
	mstn	TGF_BETA_2 domain-containing protein. (376 aa)
	HAND1	Heart and neural crest derivatives expressed 1. (192 aa)
	ENSLCAP00010052980	Aryl hydrocarbon receptor nuclear translocator. (784 aa)
	ENSLCAP00010058043	BHLH domain-containing protein. (251 aa)
	CPE	Carboxypeptidase E. (224 aa)
	ENSLCAP00010001596	Mothers against decapentaplegic homolog. (531 aa)
	ENSLCAP00010001604	Uncharacterized protein. (188 aa)
	med1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1836 aa)
	sema3c	Uncharacterized protein; Belongs to the semaphorin family. (766 aa)
	LOC108896340	Mothers against decapentaplegic homolog. (616 aa)
	ENSLCAP00010011759	Troponin I type 1b (skeletal, slow). (176 aa)
	LOC108888948	Uncharacterized protein. (525 aa)
	SMAD4	Mothers against decapentaplegic homolog. (524 aa)
	LOC108874718	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (404 aa)
	LOC108876160	Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
	Nkx2-5	NK2 homeobox 5. (338 aa)
	LOC108900474	Uncharacterized protein. (161 aa)
	Arnt2	Aryl-hydrocarbon receptor nuclear translocator 2. (741 aa)
	ENSLCAP00010023696	Neuropeptide Y receptor Y7; Belongs to the G-protein coupled receptor 1 family. (373 aa)
	LOC108895337	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (542 aa)
	zfpm2	Uncharacterized protein. (1179 aa)
	ENSLCAP00010001592	Uncharacterized protein. (117 aa)
	nog	Noggin; Belongs to the noggin family. (225 aa)
	ENSLCAP00010037509	HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1. (870 aa)
	ENSLCAP00010038275	Carboxypeptidase E. (444 aa)
	ENSLCAP00010039564	Troponin I1, slow skeletal type. (186 aa)

Your Current Organism:

Lates calcarifer

NCBI taxonomy Id: 8187
Other names: Asian seabass, Holocentrus calcarifer, L. calcarifer, barramundi, barramundi perch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Arnt2	med1	ENSLCAP00010019853	ENSLCAP00010002181	Aryl-hydrocarbon receptor nuclear translocator 2.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.407
EDNRA	ENSLCAP00010041660	ENSLCAP00010048555	ENSLCAP00010041660	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family.	0.902
ENSLCAP00010001592	ENSLCAP00010001604	ENSLCAP00010001592	ENSLCAP00010001604	Uncharacterized protein.	Uncharacterized protein.	0.491
ENSLCAP00010001596	LOC108876160	ENSLCAP00010001596	ENSLCAP00010015620	Mothers against decapentaplegic homolog.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.687
ENSLCAP00010001596	LOC108876301	ENSLCAP00010001596	ENSLCAP00010042183	Mothers against decapentaplegic homolog.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.637
ENSLCAP00010001596	LOC108896340	ENSLCAP00010001596	ENSLCAP00010011045	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.901
ENSLCAP00010001596	SMAD4	ENSLCAP00010001596	ENSLCAP00010013760	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.900
ENSLCAP00010001596	TGFBR2	ENSLCAP00010001596	ENSLCAP00010028346	Mothers against decapentaplegic homolog.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.637
ENSLCAP00010001604	ENSLCAP00010001592	ENSLCAP00010001604	ENSLCAP00010001592	Uncharacterized protein.	Uncharacterized protein.	0.491
ENSLCAP00010011759	LOC108900474	ENSLCAP00010011759	ENSLCAP00010017299	Troponin I type 1b (skeletal, slow).	Uncharacterized protein.	0.912
ENSLCAP00010011759	TNNC1	ENSLCAP00010011759	ENSLCAP00010041669	Troponin I type 1b (skeletal, slow).	Uncharacterized protein.	0.912
ENSLCAP00010039564	LOC108900474	ENSLCAP00010039564	ENSLCAP00010017299	Troponin I1, slow skeletal type.	Uncharacterized protein.	0.912
ENSLCAP00010039564	TNNC1	ENSLCAP00010039564	ENSLCAP00010041669	Troponin I1, slow skeletal type.	Uncharacterized protein.	0.912
ENSLCAP00010041081	Nkx2-5	ENSLCAP00010041081	ENSLCAP00010015634	Uncharacterized protein.	NK2 homeobox 5.	0.813
ENSLCAP00010041660	EDNRA	ENSLCAP00010041660	ENSLCAP00010048555	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.902
ENSLCAP00010052980	med1	ENSLCAP00010052980	ENSLCAP00010002181	Aryl hydrocarbon receptor nuclear translocator.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.407
ENSLCAP00010058043	Nkx2-5	ENSLCAP00010058043	ENSLCAP00010015634	BHLH domain-containing protein.	NK2 homeobox 5.	0.443
HAND1	Nkx2-5	ENSLCAP00010051445	ENSLCAP00010015634	Heart and neural crest derivatives expressed 1.	NK2 homeobox 5.	0.479
LOC108876160	ENSLCAP00010001596	ENSLCAP00010015620	ENSLCAP00010001596	Transforming growth factor beta; Belongs to the TGF-beta family.	Mothers against decapentaplegic homolog.	0.687
LOC108876160	LOC108876301	ENSLCAP00010015620	ENSLCAP00010042183	Transforming growth factor beta; Belongs to the TGF-beta family.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.970