(134 nodes) Regulation of I-kappaB kinase/NF-kappaB signaling network (Lates calcarifer)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PPM1A	Protein phosphatase, Mg2+/Mn2+ dependent 1A. (390 aa)
	Ajuba	Ajuba LIM protein. (720 aa)
	Sqstm1	Sequestosome 1. (341 aa)
	ENSLCAP00010001515	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. (444 aa)
	otud7b	Uncharacterized protein. (927 aa)
	LOC108899401	TNF_2 domain-containing protein. (254 aa)
	ENSLCAP00010003829	CARD domain-containing protein. (119 aa)
	traf3ip2	SEFIR domain-containing protein. (444 aa)
	gprc5b	G_PROTEIN_RECEP_F3_4 domain-containing protein. (424 aa)
	LOC108882618	Uncharacterized protein. (512 aa)
	tab2	Uncharacterized protein. (761 aa)
	tradd	Death domain-containing protein. (293 aa)
	DHX15	Uncharacterized protein. (767 aa)
	dhx36	Uncharacterized protein. (1079 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (680 aa)
	Ikbkb	Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta. (746 aa)
	nlrx1	NACHT domain-containing protein. (984 aa)
	zmynd11	Uncharacterized protein. (678 aa)
	LOC108873765	G_PROTEIN_RECEP_F1_2 domain-containing protein. (440 aa)
	Lpar1	Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
	Catip	Uncharacterized protein; Belongs to the peptidase C14A family. (459 aa)
	LOC108883996	C3H1-type domain-containing protein. (664 aa)
	ENSLCAP00010008403	Uncharacterized protein; Belongs to the peptidase C14A family. (480 aa)
	LOC108888296	RING-type domain-containing protein. (568 aa)
	ENSLCAP00010009573	Uncharacterized protein. (484 aa)
	C18orf32	Chromosome 18 open reading frame 32. (77 aa)
	ENSLCAP00010012249	G protein-coupled receptor, class C, group 5, member Bb. (341 aa)
	abl1	Tyrosine-protein kinase. (1148 aa)
	trim32	Uncharacterized protein. (685 aa)
	ENSLCAP00010013860	Si:dkey-181m9.8. (448 aa)
	LOC108900811	Protein kinase domain-containing protein. (856 aa)
	ENSLCAP00010014878	Heat shock protein, alpha-crystallin-related, b15; Belongs to the small heat shock protein (HSP20) family. (193 aa)
	inava	DUF3338 domain-containing protein. (590 aa)
	Sirt1	Deacetylase sirtuin-type domain-containing protein. (705 aa)
	ENSLCAP00010016091	Uncharacterized protein. (258 aa)
	LOC108889978	TNFR-Cys domain-containing protein. (275 aa)
	tirap	TIR domain-containing protein. (267 aa)
	LOC108874450	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (520 aa)
	LOC108895456	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (596 aa)
	ENSLCAP00010016623	TNFAIP3 interacting protein 1. (547 aa)
	Tifa	Uncharacterized protein. (98 aa)
	LOC108879004	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (267 aa)
	LOC108880505	Uncharacterized protein. (195 aa)
	zfand6	Uncharacterized protein. (258 aa)
	tnfsf11	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (268 aa)
	ENSLCAP00010019675	Si:ch211-108d22.2. (1541 aa)
	ENSLCAP00010019678	Leucine rich adaptor protein 1. (292 aa)
	Sharpin	SHANK-associated RH domain interacting protein. (435 aa)
	Card11	Guanylate kinase-like domain-containing protein. (281 aa)
	ENSLCAP00010020544	CARD domain-containing protein. (125 aa)
	ALPK1	Alpha-type protein kinase domain-containing protein. (1147 aa)
	myd88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (292 aa)
	otud7a	Uncharacterized protein. (964 aa)
	JMJD8	Jumonji domain containing 8. (190 aa)
	eda	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (398 aa)
	ENSLCAP00010023959	Mitogen-activated protein kinase kinase kinase 7. (606 aa)
	gapdh	Glyceraldehyde-3-phosphate dehydrogenase. (339 aa)
	ENSLCAP00010024056	Tumor necrosis factor receptor superfamily, member 1a. (440 aa)
	htr2b	G_PROTEIN_RECEP_F1_2 domain-containing protein. (473 aa)
	LOC108898754	C3H1-type domain-containing protein. (626 aa)
	traf4	TNF receptor-associated factor. (470 aa)
	Ufl1	UFM1-specific ligase 1. (771 aa)
	ikbke	Protein kinase domain-containing protein. (725 aa)
	ENSLCAP00010026940	Tumor necrosis factor, alpha-induced protein 3. (777 aa)
	ENSLCAP00010027290	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (278 aa)
	ENSLCAP00010027318	Protein phosphatase, Mg2+/Mn2+ dependent, 1Ba. (325 aa)
	LOC108879534	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa)
	Cth	Cystathionase (cystathionine gamma-lyase), like. (414 aa)
	LOC108876224	RING-type domain-containing protein. (594 aa)
	LOC108891107	Protein kinase domain-containing protein. (770 aa)
	LOC108896760	Uncharacterized protein. (1121 aa)
	ENSLCAP00010030143	P53-induced death domain protein 1. (910 aa)
	ENSLCAP00010031084	TRAF3 interacting protein 2-like. (452 aa)
	tmem101	Uncharacterized protein. (255 aa)
	ENSLCAP00010031904	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (459 aa)
	ENSLCAP00010031970	Conserved helix-loop-helix ubiquitous kinase. (763 aa)
	ENSLCAP00010033122	ADP-ribosylation factor 2b. (648 aa)
	LOC108883544	RING-type domain-containing protein. (345 aa)
	nr1h4	Uncharacterized protein. (485 aa)
	nod2	Uncharacterized protein. (988 aa)
	s100b	Uncharacterized protein; Belongs to the S-100 family. (94 aa)
	LURAP1L	Uncharacterized protein. (202 aa)
	ENSLCAP00010034930	RanBP-type and C3HC4-type zinc finger containing 1. (468 aa)
	ENSLCAP00010035756	SEFIR domain-containing protein. (182 aa)
	usp10	Ubiquitin carboxyl-terminal hydrolase. (883 aa)
	pink1	Protein kinase domain-containing protein. (575 aa)
	LOC108892729	Uncharacterized protein. (757 aa)
	ddx1	Uncharacterized protein. (743 aa)
	hspb1	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (203 aa)
	ENSLCAP00010038601	Protein phosphatase, Mg2+/Mn2+ dependent, 1Bb. (448 aa)
	traf6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (609 aa)
	LOC108900828	PPM-type phosphatase domain-containing protein. (436 aa)
	nod1	Uncharacterized protein. (939 aa)
	ENSLCAP00010042190	NACHT domain-containing protein. (1278 aa)
	tbk1	Uncharacterized protein. (723 aa)
	ENSLCAP00010044467	BRCT domain-containing protein. (486 aa)
	ENSLCAP00010044639	Uncharacterized protein. (190 aa)
	optn	CCHC NOA-type domain-containing protein. (526 aa)
	LOC108894452	Uncharacterized protein. (710 aa)
	ENSLCAP00010047467	Nuclear receptor subfamily 1, group d, member 1. (549 aa)
	ENSLCAP00010048315	Nuclear receptor subfamily 1, group D, member 4b. (392 aa)
	ENSLCAP00010048326	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (639 aa)
	ENSLCAP00010048390	EF-hand domain-containing protein. (102 aa)
	cflar	Uncharacterized protein; Belongs to the peptidase C14A family. (516 aa)
	LOC108874357	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (463 aa)
	Edar	Ectodysplasin A receptor. (487 aa)
	tab3	Uncharacterized protein. (616 aa)
	ENSLCAP00010050445	NEMO domain-containing protein. (371 aa)
	ppm1a	PPM-type phosphatase domain-containing protein. (390 aa)
	LOC108878374	Interleukin-1. (278 aa)
	irak4	Protein kinase domain-containing protein. (458 aa)
	ENSLCAP00010051369	Nuclear receptor subfamily 1, group D, member 4a. (575 aa)
	ripk2	Uncharacterized protein. (603 aa)
	trim62	Uncharacterized protein. (475 aa)
	pink1-2	Serine/threonine-protein kinase PINK1, mitochondrial-like. (575 aa)
	mul1	RING-type domain-containing protein. (352 aa)
	ENSLCAP00010053450	RING-type domain-containing protein. (609 aa)
	LOC108886974	Glyceraldehyde-3-phosphate dehydrogenase. (347 aa)
	Riok3	Serine/threonine-protein kinase RIO3; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (498 aa)
	ENSLCAP00010053976	Uncharacterized protein. (294 aa)
	ash1l	Uncharacterized protein. (2045 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
	tank	TBD domain-containing protein. (534 aa)
	LOC108885955	Protein S100; Belongs to the S-100 family. (88 aa)
	ENSLCAP00010054907	TNFR-Cys domain-containing protein. (380 aa)
	LOC108892171	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (578 aa)
	LOC108898940	DUF3338 domain-containing protein. (617 aa)
	LOC108888464	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (667 aa)
	ddx21	Uncharacterized protein. (749 aa)
	abl2	Tyrosine-protein kinase. (1220 aa)
	ENSLCAP00010058335	Uncharacterized protein. (341 aa)
	LOC108878507	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (566 aa)
	ENSLCAP00010059112	Caspase 8, apoptosis-related cysteine peptidase, like 2; Belongs to the peptidase C14A family. (647 aa)
	LOC108887194	Uncharacterized protein. (1398 aa)

Your Current Organism:

Lates calcarifer

NCBI taxonomy Id: 8187
Other names: Asian seabass, Holocentrus calcarifer, L. calcarifer, barramundi, barramundi perch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALPK1	ENSLCAP00010001515	ENSLCAP00010021116	ENSLCAP00010001515	Alpha-type protein kinase domain-containing protein.	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily.	0.504
ALPK1	ENSLCAP00010023959	ENSLCAP00010021116	ENSLCAP00010023959	Alpha-type protein kinase domain-containing protein.	Mitogen-activated protein kinase kinase kinase 7.	0.504
ALPK1	Tifa	ENSLCAP00010021116	ENSLCAP00010016983	Alpha-type protein kinase domain-containing protein.	Uncharacterized protein.	0.871
ALPK1	ripk2	ENSLCAP00010021116	ENSLCAP00010051481	Alpha-type protein kinase domain-containing protein.	Uncharacterized protein.	0.418
ALPK1	traf6	ENSLCAP00010021116	ENSLCAP00010039774	Alpha-type protein kinase domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.649
Card11	ENSLCAP00010001515	ENSLCAP00010020526	ENSLCAP00010001515	Guanylate kinase-like domain-containing protein.	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily.	0.663
Card11	ENSLCAP00010020544	ENSLCAP00010020526	ENSLCAP00010020544	Guanylate kinase-like domain-containing protein.	CARD domain-containing protein.	0.900
Card11	ENSLCAP00010023959	ENSLCAP00010020526	ENSLCAP00010023959	Guanylate kinase-like domain-containing protein.	Mitogen-activated protein kinase kinase kinase 7.	0.663
Card11	ENSLCAP00010026940	ENSLCAP00010020526	ENSLCAP00010026940	Guanylate kinase-like domain-containing protein.	Tumor necrosis factor, alpha-induced protein 3.	0.415
Card11	ENSLCAP00010031970	ENSLCAP00010020526	ENSLCAP00010031970	Guanylate kinase-like domain-containing protein.	Conserved helix-loop-helix ubiquitous kinase.	0.569
Card11	ENSLCAP00010050445	ENSLCAP00010020526	ENSLCAP00010050445	Guanylate kinase-like domain-containing protein.	NEMO domain-containing protein.	0.769
Card11	Ikbkb	ENSLCAP00010020526	ENSLCAP00010005949	Guanylate kinase-like domain-containing protein.	Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta.	0.628
Card11	LOC108879534	ENSLCAP00010020526	ENSLCAP00010027675	Guanylate kinase-like domain-containing protein.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.542
Card11	LOC108888464	ENSLCAP00010020526	ENSLCAP00010056224	Guanylate kinase-like domain-containing protein.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.542
Card11	LOC108891107	ENSLCAP00010020526	ENSLCAP00010028815	Guanylate kinase-like domain-containing protein.	Protein kinase domain-containing protein.	0.628
Card11	PRKCA	ENSLCAP00010020526	ENSLCAP00010054225	Guanylate kinase-like domain-containing protein.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.542
Card11	PRKCB	ENSLCAP00010020526	ENSLCAP00010005829	Guanylate kinase-like domain-containing protein.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.542
Card11	ripk2	ENSLCAP00010020526	ENSLCAP00010051481	Guanylate kinase-like domain-containing protein.	Uncharacterized protein.	0.485
Card11	tab2	ENSLCAP00010020526	ENSLCAP00010004220	Guanylate kinase-like domain-containing protein.	Uncharacterized protein.	0.455
Card11	tab3	ENSLCAP00010020526	ENSLCAP00010049860	Guanylate kinase-like domain-containing protein.	Uncharacterized protein.	0.490