(88 nodes) Positive regulation of I-kappaB kinase/NF-kappaB signaling network (Lates calcarifer)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC108873765	G_PROTEIN_RECEP_F1_2 domain-containing protein. (440 aa)
	LOC108887194	Uncharacterized protein. (1398 aa)
	ENSLCAP00010059112	Caspase 8, apoptosis-related cysteine peptidase, like 2; Belongs to the peptidase C14A family. (647 aa)
	ENSLCAP00010058335	Uncharacterized protein. (341 aa)
	abl2	Tyrosine-protein kinase. (1220 aa)
	ddx21	Uncharacterized protein. (749 aa)
	LOC108888464	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (667 aa)
	LOC108898940	DUF3338 domain-containing protein. (617 aa)
	ENSLCAP00010054907	TNFR-Cys domain-containing protein. (380 aa)
	LOC108885955	Protein S100; Belongs to the S-100 family. (88 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
	LOC108886974	Glyceraldehyde-3-phosphate dehydrogenase. (347 aa)
	ENSLCAP00010053450	RING-type domain-containing protein. (609 aa)
	mul1	RING-type domain-containing protein. (352 aa)
	pink1-2	Serine/threonine-protein kinase PINK1, mitochondrial-like. (575 aa)
	trim62	Uncharacterized protein. (475 aa)
	ripk2	Uncharacterized protein. (603 aa)
	irak4	Protein kinase domain-containing protein. (458 aa)
	ENSLCAP00010050445	NEMO domain-containing protein. (371 aa)
	tab3	Uncharacterized protein. (616 aa)
	Edar	Ectodysplasin A receptor. (487 aa)
	LOC108874357	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (463 aa)
	cflar	Uncharacterized protein; Belongs to the peptidase C14A family. (516 aa)
	ENSLCAP00010048390	EF-hand domain-containing protein. (102 aa)
	LOC108894452	Uncharacterized protein. (710 aa)
	ENSLCAP00010044639	Uncharacterized protein. (190 aa)
	ENSLCAP00010044467	BRCT domain-containing protein. (486 aa)
	tbk1	Uncharacterized protein. (723 aa)
	ENSLCAP00010042190	NACHT domain-containing protein. (1278 aa)
	nod1	Uncharacterized protein. (939 aa)
	ddx1	Uncharacterized protein. (743 aa)
	LOC108892729	Uncharacterized protein. (757 aa)
	pink1	Protein kinase domain-containing protein. (575 aa)
	ENSLCAP00010035756	SEFIR domain-containing protein. (182 aa)
	ENSLCAP00010034930	RanBP-type and C3HC4-type zinc finger containing 1. (468 aa)
	LURAP1L	Uncharacterized protein. (202 aa)
	nod2	Uncharacterized protein. (988 aa)
	LOC108883544	RING-type domain-containing protein. (345 aa)
	ENSLCAP00010033122	ADP-ribosylation factor 2b. (648 aa)
	ENSLCAP00010031904	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (459 aa)
	tmem101	Uncharacterized protein. (255 aa)
	ENSLCAP00010031084	TRAF3 interacting protein 2-like. (452 aa)
	s100b	Uncharacterized protein; Belongs to the S-100 family. (94 aa)
	LOC108896760	Uncharacterized protein. (1121 aa)
	LOC108891107	Protein kinase domain-containing protein. (770 aa)
	LOC108876224	RING-type domain-containing protein. (594 aa)
	Cth	Cystathionase (cystathionine gamma-lyase), like. (414 aa)
	LOC108879534	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa)
	ENSLCAP00010027290	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (278 aa)
	ikbke	Protein kinase domain-containing protein. (725 aa)
	htr2b	G_PROTEIN_RECEP_F1_2 domain-containing protein. (473 aa)
	ENSLCAP00010024056	Tumor necrosis factor receptor superfamily, member 1a. (440 aa)
	gapdh	Glyceraldehyde-3-phosphate dehydrogenase. (339 aa)
	ENSLCAP00010023959	Mitogen-activated protein kinase kinase kinase 7. (606 aa)
	JMJD8	Jumonji domain containing 8. (190 aa)
	myd88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (292 aa)
	ALPK1	Alpha-type protein kinase domain-containing protein. (1147 aa)
	ENSLCAP00010020544	CARD domain-containing protein. (125 aa)
	Card11	Guanylate kinase-like domain-containing protein. (281 aa)
	Sharpin	SHANK-associated RH domain interacting protein. (435 aa)
	ENSLCAP00010019678	Leucine rich adaptor protein 1. (292 aa)
	ENSLCAP00010019675	Si:ch211-108d22.2. (1541 aa)
	tnfsf11	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (268 aa)
	LOC108880505	Uncharacterized protein. (195 aa)
	LOC108879004	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (267 aa)
	Tifa	Uncharacterized protein. (98 aa)
	tirap	TIR domain-containing protein. (267 aa)
	inava	DUF3338 domain-containing protein. (590 aa)
	LOC108900811	Protein kinase domain-containing protein. (856 aa)
	ENSLCAP00010013860	Si:dkey-181m9.8. (448 aa)
	trim32	Uncharacterized protein. (685 aa)
	abl1	Tyrosine-protein kinase. (1148 aa)
	ENSLCAP00010012249	G protein-coupled receptor, class C, group 5, member Bb. (341 aa)
	C18orf32	Chromosome 18 open reading frame 32. (77 aa)
	LOC108888296	RING-type domain-containing protein. (568 aa)
	ENSLCAP00010008403	Uncharacterized protein; Belongs to the peptidase C14A family. (480 aa)
	Lpar1	Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
	Ikbkb	Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta. (746 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (680 aa)
	dhx36	Uncharacterized protein. (1079 aa)
	DHX15	Uncharacterized protein. (767 aa)
	tradd	Death domain-containing protein. (293 aa)
	tab2	Uncharacterized protein. (761 aa)
	gprc5b	G_PROTEIN_RECEP_F3_4 domain-containing protein. (424 aa)
	traf3ip2	SEFIR domain-containing protein. (444 aa)
	LOC108899401	TNF_2 domain-containing protein. (254 aa)
	ENSLCAP00010001515	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. (444 aa)
	Ajuba	Ajuba LIM protein. (720 aa)

Your Current Organism:

Lates calcarifer

NCBI taxonomy Id: 8187
Other names: Asian seabass, Holocentrus calcarifer, L. calcarifer, barramundi, barramundi perch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALPK1	ENSLCAP00010001515	ENSLCAP00010021116	ENSLCAP00010001515	Alpha-type protein kinase domain-containing protein.	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily.	0.504
ALPK1	ENSLCAP00010023959	ENSLCAP00010021116	ENSLCAP00010023959	Alpha-type protein kinase domain-containing protein.	Mitogen-activated protein kinase kinase kinase 7.	0.504
ALPK1	Tifa	ENSLCAP00010021116	ENSLCAP00010016983	Alpha-type protein kinase domain-containing protein.	Uncharacterized protein.	0.871
ALPK1	ripk2	ENSLCAP00010021116	ENSLCAP00010051481	Alpha-type protein kinase domain-containing protein.	Uncharacterized protein.	0.418
Card11	ENSLCAP00010001515	ENSLCAP00010020526	ENSLCAP00010001515	Guanylate kinase-like domain-containing protein.	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily.	0.663
Card11	ENSLCAP00010020544	ENSLCAP00010020526	ENSLCAP00010020544	Guanylate kinase-like domain-containing protein.	CARD domain-containing protein.	0.900
Card11	ENSLCAP00010023959	ENSLCAP00010020526	ENSLCAP00010023959	Guanylate kinase-like domain-containing protein.	Mitogen-activated protein kinase kinase kinase 7.	0.663
Card11	ENSLCAP00010050445	ENSLCAP00010020526	ENSLCAP00010050445	Guanylate kinase-like domain-containing protein.	NEMO domain-containing protein.	0.769
Card11	Ikbkb	ENSLCAP00010020526	ENSLCAP00010005949	Guanylate kinase-like domain-containing protein.	Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta.	0.628
Card11	LOC108879534	ENSLCAP00010020526	ENSLCAP00010027675	Guanylate kinase-like domain-containing protein.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.542
Card11	LOC108888464	ENSLCAP00010020526	ENSLCAP00010056224	Guanylate kinase-like domain-containing protein.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.542
Card11	LOC108891107	ENSLCAP00010020526	ENSLCAP00010028815	Guanylate kinase-like domain-containing protein.	Protein kinase domain-containing protein.	0.628
Card11	PRKCA	ENSLCAP00010020526	ENSLCAP00010054225	Guanylate kinase-like domain-containing protein.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.542
Card11	PRKCB	ENSLCAP00010020526	ENSLCAP00010005829	Guanylate kinase-like domain-containing protein.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.542
Card11	ripk2	ENSLCAP00010020526	ENSLCAP00010051481	Guanylate kinase-like domain-containing protein.	Uncharacterized protein.	0.485
Card11	tab2	ENSLCAP00010020526	ENSLCAP00010004220	Guanylate kinase-like domain-containing protein.	Uncharacterized protein.	0.455
Card11	tab3	ENSLCAP00010020526	ENSLCAP00010049860	Guanylate kinase-like domain-containing protein.	Uncharacterized protein.	0.490
Cth	LOC108886974	ENSLCAP00010028407	ENSLCAP00010053573	Cystathionase (cystathionine gamma-lyase), like.	Glyceraldehyde-3-phosphate dehydrogenase.	0.452
Cth	gapdh	ENSLCAP00010028407	ENSLCAP00010023964	Cystathionase (cystathionine gamma-lyase), like.	Glyceraldehyde-3-phosphate dehydrogenase.	0.452
DHX15	LOC108892729	ENSLCAP00010004853	ENSLCAP00010036328	Uncharacterized protein.	Uncharacterized protein.	0.900