(109 nodes) Regulation of cysteine-type endopeptidase activity involved in apoptotic process network (Lates calcarifer)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSLCAP00010000256	FIIND domain-containing protein. (1226 aa)
	tfap4	BHLH domain-containing protein. (333 aa)
	ENSLCAP00010001779	Uveal autoantigen with coiled-coil domains and ankyrin repeats b. (1346 aa)
	map2k5	Uncharacterized protein; Belongs to the protein kinase superfamily. (449 aa)
	LOC108880245	Uncharacterized protein. (268 aa)
	LOC108899584	Uncharacterized protein. (205 aa)
	ENSLCAP00010003829	CARD domain-containing protein. (119 aa)
	ENSLCAP00010004537	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (258 aa)
	ENSLCAP00010005441	Uncharacterized protein. (478 aa)
	eif2ak3	Protein kinase domain-containing protein. (1105 aa)
	pdcd5	Uncharacterized protein. (126 aa)
	LOC108873765	G_PROTEIN_RECEP_F1_2 domain-containing protein. (440 aa)
	ENSLCAP00010007608	Aquaporin 1a (Colton blood group), tandem duplicate 2; Belongs to the MIP/aquaporin (TC 1.A.8) family. (277 aa)
	LOC108883341	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (265 aa)
	LOC108883342	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (280 aa)
	ENSLCAP00010008148	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	Catip	Uncharacterized protein; Belongs to the peptidase C14A family. (459 aa)
	ENSLCAP00010008403	Uncharacterized protein; Belongs to the peptidase C14A family. (480 aa)
	xiap	RING-type domain-containing protein. (466 aa)
	hip1r	Uncharacterized protein. (1115 aa)
	LOC108875423	Uncharacterized protein. (654 aa)
	LOC108875435	Uncharacterized protein; Belongs to the peptidase C1 family. (325 aa)
	ST18	MYT1 domain-containing protein. (1130 aa)
	oxt	Uncharacterized protein; Belongs to the vasopressin/oxytocin family. (156 aa)
	lamtor5	Uncharacterized protein. (91 aa)
	ENSLCAP00010012956	Ring finger protein 34b. (330 aa)
	ENSLCAP00010013205	Nerve growth factor receptor a (TNFR superfamily, member 16). (268 aa)
	Ints1	Integrator complex subunit 1. (2170 aa)
	bax	Uncharacterized protein. (192 aa)
	pak2	Non-specific serine/threonine protein kinase. (530 aa)
	dhcr24	FAD-binding PCMH-type domain-containing protein. (516 aa)
	fas	Uncharacterized protein. (324 aa)
	LOC108880779	Uncharacterized protein. (146 aa)
	LOC108890590	Uncharacterized protein. (207 aa)
	LOC108890578	Uncharacterized protein. (207 aa)
	ENSLCAP00010015716	Uncharacterized protein. (213 aa)
	ENSLCAP00010015729	Uncharacterized protein. (213 aa)
	Sirt1	Deacetylase sirtuin-type domain-containing protein. (705 aa)
	ENSLCAP00010016433	Uncharacterized protein. (693 aa)
	LOC108879004	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (267 aa)
	ENSLCAP00010017685	CARD domain-containing protein. (123 aa)
	Ptgs2	Prostaglandin-endoperoxide synthase 2b. (612 aa)
	LOC108880508	Uncharacterized protein. (205 aa)
	LOC108896372	TNF_2 domain-containing protein. (242 aa)
	prdx3	Thioredoxin domain-containing protein. (239 aa)
	LOC108896747	Uncharacterized protein. (285 aa)
	ENSLCAP00010019962	Crystallin, alpha B, b; Belongs to the small heat shock protein (HSP20) family. (229 aa)
	LOC108893387	Uncharacterized protein. (641 aa)
	gas6	Uncharacterized protein. (651 aa)
	casp2	Uncharacterized protein; Belongs to the peptidase C14A family. (468 aa)
	mgmt	DNA_binding_1 domain-containing protein. (240 aa)
	Nle1	Notchless homolog 1 (Drosophila). (486 aa)
	arl6ip5	PRA1 family protein. (191 aa)
	ENSLCAP00010023720	Establishment of sister chromatid cohesion N-acetyltransferase 2. (511 aa)
	Casp8ap2	Uncharacterized protein. (1358 aa)
	TFAP4	BHLH domain-containing protein. (332 aa)
	LOC108885467	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (258 aa)
	ENSLCAP00010027290	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (278 aa)
	LOC108876072	Uncharacterized protein. (269 aa)
	diablo	Uncharacterized protein. (237 aa)
	fnip1	UDENN FNIP1/2-type domain-containing protein. (1328 aa)
	CAAP1	Uncharacterized protein. (333 aa)
	ENSLCAP00010030057	Uncharacterized protein. (255 aa)
	ENSLCAP00010030143	P53-induced death domain protein 1. (910 aa)
	PAK2	Non-specific serine/threonine protein kinase. (514 aa)
	ENSLCAP00010030985	Uncharacterized protein. (179 aa)
	LOC108882190	Uncharacterized protein. (536 aa)
	sox7	Uncharacterized protein. (375 aa)
	ENSLCAP00010032184	Uncharacterized protein. (174 aa)
	LOC108899818	GRAM domain-containing protein. (617 aa)
	LOC108883544	RING-type domain-containing protein. (345 aa)
	Hip1	Huntingtin interacting protein 1. (1074 aa)
	ENSLCAP00010034292	UPAR/Ly6 domain-containing protein. (321 aa)
	ENSLCAP00010036940	MALT paracaspase 1. (806 aa)
	LOC108888694	Uncharacterized protein. (635 aa)
	p2rx1	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (421 aa)
	bad	Uncharacterized protein. (229 aa)
	LOC108901190	Uncharacterized protein. (651 aa)
	f3	Uncharacterized protein. (289 aa)
	Sfrp2	Secreted frizzled-related protein 2. (284 aa)
	bcl2l11	Bclx_interact domain-containing protein. (284 aa)
	rffl	RING-type domain-containing protein. (348 aa)
	prdx5	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (190 aa)
	ENSLCAP00010044755	Si:ch73-252p3.1. (1199 aa)
	ENSLCAP00010044762	Uncharacterized protein. (873 aa)
	LOC108886611	Uncharacterized protein. (389 aa)
	aifm1	Uncharacterized protein. (745 aa)
	cflar	Uncharacterized protein; Belongs to the peptidase C14A family. (516 aa)
	LOC108893768	GRAM domain-containing protein. (586 aa)
	ENSLCAP00010050095	Uncharacterized protein. (723 aa)
	ccn1	Uncharacterized protein. (374 aa)
	mul1	RING-type domain-containing protein. (352 aa)
	LOC108877025	Uncharacterized protein; Belongs to the peptidase C1 family. (331 aa)
	rnf34	RING-type domain-containing protein. (378 aa)
	LOC108881344	Uncharacterized protein. (186 aa)
	ENSLCAP00010054078	NACHT domain-containing protein. (935 aa)
	dap	Uncharacterized protein. (123 aa)
	cdkn2d	ANK_REP_REGION domain-containing protein. (164 aa)
	ENSLCAP00010055865	Uncharacterized protein. (780 aa)
	LOC108898892	PRA1 family protein. (190 aa)
	ENSLCAP00010056473	Programmed cell death 2. (287 aa)
	ENSLCAP00010057066	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (363 aa)
	usp47	USP domain-containing protein; Belongs to the peptidase C19 family. (1426 aa)
	ENSLCAP00010058119	MALT paracaspase 2. (565 aa)
	ENSLCAP00010059112	Caspase 8, apoptosis-related cysteine peptidase, like 2; Belongs to the peptidase C14A family. (647 aa)
	prr7	Uncharacterized protein. (316 aa)
	nkx3-1	Homeobox domain-containing protein. (195 aa)
	casp9	Uncharacterized protein; Belongs to the peptidase C14A family. (457 aa)
	ENSLCAP00010059935	Uncharacterized protein. (772 aa)

Your Current Organism:

Lates calcarifer

NCBI taxonomy Id: 8187
Other names: Asian seabass, Holocentrus calcarifer, L. calcarifer, barramundi, barramundi perch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Casp8ap2	Catip	ENSLCAP00010023849	ENSLCAP00010008252	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.443
Casp8ap2	ENSLCAP00010008403	ENSLCAP00010023849	ENSLCAP00010008403	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.514
Casp8ap2	ENSLCAP00010017685	ENSLCAP00010023849	ENSLCAP00010017685	Uncharacterized protein.	CARD domain-containing protein.	0.425
Casp8ap2	ENSLCAP00010059112	ENSLCAP00010023849	ENSLCAP00010059112	Uncharacterized protein.	Caspase 8, apoptosis-related cysteine peptidase, like 2; Belongs to the peptidase C14A family.	0.514
Catip	Casp8ap2	ENSLCAP00010008252	ENSLCAP00010023849	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.443
Catip	ENSLCAP00010003829	ENSLCAP00010008252	ENSLCAP00010003829	Uncharacterized protein; Belongs to the peptidase C14A family.	CARD domain-containing protein.	0.634
Catip	ENSLCAP00010027290	ENSLCAP00010008252	ENSLCAP00010027290	Uncharacterized protein; Belongs to the peptidase C14A family.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.800
Catip	ENSLCAP00010030057	ENSLCAP00010008252	ENSLCAP00010030057	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.425
Catip	ENSLCAP00010036940	ENSLCAP00010008252	ENSLCAP00010036940	Uncharacterized protein; Belongs to the peptidase C14A family.	MALT paracaspase 1.	0.594
Catip	ENSLCAP00010058119	ENSLCAP00010008252	ENSLCAP00010058119	Uncharacterized protein; Belongs to the peptidase C14A family.	MALT paracaspase 2.	0.594
Catip	LOC108875423	ENSLCAP00010008252	ENSLCAP00010010597	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.594
Catip	LOC108879004	ENSLCAP00010008252	ENSLCAP00010017663	Uncharacterized protein; Belongs to the peptidase C14A family.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.835
Catip	LOC108893387	ENSLCAP00010008252	ENSLCAP00010021098	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.425
Catip	LOC108899584	ENSLCAP00010008252	ENSLCAP00010003821	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.634
Catip	casp2	ENSLCAP00010008252	ENSLCAP00010021664	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.482
Catip	casp9	ENSLCAP00010008252	ENSLCAP00010059818	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.555
Catip	cflar	ENSLCAP00010008252	ENSLCAP00010048611	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.911
Catip	fas	ENSLCAP00010008252	ENSLCAP00010015051	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.877
Catip	xiap	ENSLCAP00010008252	ENSLCAP00010009784	Uncharacterized protein; Belongs to the peptidase C14A family.	RING-type domain-containing protein.	0.438
ENSLCAP00010000256	ENSLCAP00010003829	ENSLCAP00010000256	ENSLCAP00010003829	FIIND domain-containing protein.	CARD domain-containing protein.	0.426