(72 nodes) Regulation of myeloid cell differentiation network (Lates calcarifer)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IL12B	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (319 aa)
	tnfaip6	Uncharacterized protein. (263 aa)
	ENSLCAP00010041366	GATA binding protein 1a. (416 aa)
	LOC108885576	BHLH domain-containing protein. (470 aa)
	LOC108889535	Uncharacterized protein. (270 aa)
	meis2	Homeobox domain-containing protein. (490 aa)
	LOC108890572	BHLH domain-containing protein. (512 aa)
	Cib1	Calcium and integrin binding 1 (calmyrin). (183 aa)
	tesc	Uncharacterized protein. (220 aa)
	LOC108890483	CCAAT/enhancer-binding protein. (301 aa)
	Ocstamp	Osteoclast stimulatory transmembrane protein. (384 aa)
	fam210b	DUF1279 domain-containing protein. (313 aa)
	ctr9	TPR_REGION domain-containing protein. (1164 aa)
	Dcstamp	DC_STAMP domain-containing protein. (357 aa)
	ENSLCAP00010030346	G protein-coupled receptor 137Bb. (399 aa)
	meis1	Uncharacterized protein. (421 aa)
	tmem64	Uncharacterized protein. (352 aa)
	pithd1	PITH domain-containing protein. (211 aa)
	Faxdc2	Fatty acid hydroxylase domain containing 2; Belongs to the sterol desaturase family. (391 aa)
	ENSLCAP00010026208	Meis homeobox 2a. (401 aa)
	Inpp5d	Inositol polyphosphate-5-phosphatase D. (1087 aa)
	tmem178a	Uncharacterized protein. (339 aa)
	il34	Uncharacterized protein. (285 aa)
	MITF	BHLH domain-containing protein. (514 aa)
	LOC108889369	Fe2OG dioxygenase domain-containing protein. (494 aa)
	hspa9	Uncharacterized protein; Belongs to the heat shock protein 70 family. (675 aa)
	LOC108898398	Uncharacterized protein. (163 aa)
	ripk1	Uncharacterized protein. (684 aa)
	LOC108888943	Uncharacterized protein. (452 aa)
	tnfsf11	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (268 aa)
	LOC108880505	Uncharacterized protein. (195 aa)
	CLDN18	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (259 aa)
	ENSLCAP00010017685	CARD domain-containing protein. (123 aa)
	LOC108896950	BHLH domain-containing protein. (406 aa)
	LOC108876160	Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
	LOC108879814	EF-hand domain-containing protein. (216 aa)
	il12b	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (353 aa)
	LOC108883933	SAP domain-containing protein. (1724 aa)
	ENSLCAP00010012619	Zgc:91849. (768 aa)
	lef1	HMG box domain-containing protein. (379 aa)
	ctnnbip1	ICAT domain-containing protein. (142 aa)
	LOC108885305	Uncharacterized protein. (935 aa)
	ENSLCAP00010009573	Uncharacterized protein. (484 aa)
	LOC108895835	ANK_REP_REGION domain-containing protein. (307 aa)
	ENSLCAP00010008403	Uncharacterized protein; Belongs to the peptidase C14A family. (480 aa)
	Catip	Uncharacterized protein; Belongs to the peptidase C14A family. (459 aa)
	fstl3	Uncharacterized protein. (295 aa)
	Nf1	Neurofibromin 1b. (2806 aa)
	Mtor	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2508 aa)
	TNFRSF11B	TNFR-Cys domain-containing protein. (424 aa)
	LOC108895376	Med12 domain-containing protein. (2147 aa)
	LOC108892989	Uncharacterized protein. (243 aa)
	med1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1836 aa)
	LOC108903047	SAP domain-containing protein. (1324 aa)
	ENSLCAP00010059112	Caspase 8, apoptosis-related cysteine peptidase, like 2; Belongs to the peptidase C14A family. (647 aa)
	LOC108896950-2	Microphthalmia-associated transcription factor-like. (406 aa)
	gata1	Uncharacterized protein. (365 aa)
	rb1	Uncharacterized protein. (913 aa)
	ENSLCAP00010053195	Uncharacterized protein. (155 aa)
	mturn	Uncharacterized protein. (129 aa)
	Cdc73	Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae). (542 aa)
	mpl	Uncharacterized protein. (643 aa)
	ENSLCAP00010050298	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (219 aa)
	gabpa	Uncharacterized protein. (441 aa)
	gpr171	G_PROTEIN_RECEP_F1_2 domain-containing protein. (344 aa)
	RPS19	Ribosomal protein S19. (159 aa)
	ENSLCAP00010048560	HCLS1 associated protein X-1. (152 aa)
	nfkbia	ANK_REP_REGION domain-containing protein. (319 aa)
	ENSLCAP00010046396	Uncharacterized protein. (331 aa)
	cnot4	Uncharacterized protein. (792 aa)
	LOC108877909	Fe2OG dioxygenase domain-containing protein. (509 aa)
	ankrd54	ANK_REP_REGION domain-containing protein. (319 aa)

Your Current Organism:

Lates calcarifer

NCBI taxonomy Id: 8187
Other names: Asian seabass, Holocentrus calcarifer, L. calcarifer, barramundi, barramundi perch

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLDN18	ENSLCAP00010050298	ENSLCAP00010018221	ENSLCAP00010050298	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.660
Catip	LOC108880505	ENSLCAP00010008252	ENSLCAP00010018598	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.953
Catip	ripk1	ENSLCAP00010008252	ENSLCAP00010020400	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.932
Cdc73	ctr9	ENSLCAP00010052557	ENSLCAP00010033376	Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae).	TPR_REGION domain-containing protein.	0.999
Cdc73	lef1	ENSLCAP00010052557	ENSLCAP00010010894	Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae).	HMG box domain-containing protein.	0.632
Dcstamp	Ocstamp	ENSLCAP00010032021	ENSLCAP00010035183	DC_STAMP domain-containing protein.	Osteoclast stimulatory transmembrane protein.	0.622
Dcstamp	tnfsf11	ENSLCAP00010032021	ENSLCAP00010018749	DC_STAMP domain-containing protein.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.573
ENSLCAP00010008403	LOC108880505	ENSLCAP00010008403	ENSLCAP00010018598	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.972
ENSLCAP00010008403	ripk1	ENSLCAP00010008403	ENSLCAP00010020400	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.950
ENSLCAP00010009573	LOC108876160	ENSLCAP00010009573	ENSLCAP00010015620	Uncharacterized protein.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.587
ENSLCAP00010009573	LOC108889535	ENSLCAP00010009573	ENSLCAP00010039536	Uncharacterized protein.	Uncharacterized protein.	0.400
ENSLCAP00010009573	tnfsf11	ENSLCAP00010009573	ENSLCAP00010018749	Uncharacterized protein.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.410
ENSLCAP00010017685	LOC108880505	ENSLCAP00010017685	ENSLCAP00010018598	CARD domain-containing protein.	Uncharacterized protein.	0.917
ENSLCAP00010017685	ripk1	ENSLCAP00010017685	ENSLCAP00010020400	CARD domain-containing protein.	Uncharacterized protein.	0.412
ENSLCAP00010041366	Mtor	ENSLCAP00010041366	ENSLCAP00010004314	GATA binding protein 1a.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.454
ENSLCAP00010050298	CLDN18	ENSLCAP00010050298	ENSLCAP00010018221	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.660
ENSLCAP00010059112	LOC108880505	ENSLCAP00010059112	ENSLCAP00010018598	Caspase 8, apoptosis-related cysteine peptidase, like 2; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.996
ENSLCAP00010059112	ripk1	ENSLCAP00010059112	ENSLCAP00010020400	Caspase 8, apoptosis-related cysteine peptidase, like 2; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.992
IL12B	il12b	ENSLCAP00010044254	ENSLCAP00010014999	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily.	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily.	0.906
LOC108876160	ENSLCAP00010009573	ENSLCAP00010015620	ENSLCAP00010009573	Transforming growth factor beta; Belongs to the TGF-beta family.	Uncharacterized protein.	0.587