(88 nodes) Positive regulation of angiogenesis network (Lates calcarifer)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	CXCR3	C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (370 aa)
	ENSLCAP00010000231	BMP binding endothelial regulator. (667 aa)
	ANGPTL3	Fibrinogen C-terminal domain-containing protein. (474 aa)
	aggf1	Uncharacterized protein. (742 aa)
	ENSLCAP00010002403	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (752 aa)
	utp15	WD_REPEATS_REGION domain-containing protein. (531 aa)
	LOC108901542	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	Hmga2	High mobility group AT-hook 2. (91 aa)
	ENSLCAP00010005004	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (221 aa)
	brca1	Uncharacterized protein. (1411 aa)
	LOC108886096	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (201 aa)
	ENSLCAP00010007608	Aquaporin 1a (Colton blood group), tandem duplicate 2; Belongs to the MIP/aquaporin (TC 1.A.8) family. (277 aa)
	LOC108883341	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (265 aa)
	LOC108883342	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (280 aa)
	LOC108883996	C3H1-type domain-containing protein. (664 aa)
	ENSLCAP00010008602	Junction plakoglobin a. (729 aa)
	LOC108873688	PH domain-containing protein. (786 aa)
	LOC108883167	Protein S100; Belongs to the S-100 family. (107 aa)
	LOC108875435	Uncharacterized protein; Belongs to the peptidase C1 family. (325 aa)
	LOC108888640	Protein S100; Belongs to the S-100 family. (107 aa)
	LOC108895796	Uncharacterized protein. (1027 aa)
	LOC108879894	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (358 aa)
	LOC108899257	Uncharacterized protein. (131 aa)
	ENSLCAP00010012071	Elastin microfibril interfacer 2b. (960 aa)
	ramp2	Uncharacterized protein. (237 aa)
	ENSLCAP00010014878	Heat shock protein, alpha-crystallin-related, b15; Belongs to the small heat shock protein (HSP20) family. (193 aa)
	Sirt1	Deacetylase sirtuin-type domain-containing protein. (705 aa)
	emilin1	Uncharacterized protein. (1139 aa)
	sash1	Uncharacterized protein. (1362 aa)
	LOC108886282	Uncharacterized protein; Belongs to the cytochrome P450 family. (559 aa)
	LOC108896747	Uncharacterized protein. (285 aa)
	cd34	Uncharacterized protein. (354 aa)
	Tbxa2r	Thromboxane A2 receptor; Belongs to the G-protein coupled receptor 1 family. (324 aa)
	ENSLCAP00010021275	Uncharacterized protein. (692 aa)
	JMJD8	Jumonji domain containing 8. (190 aa)
	angptl3	Fibrinogen C-terminal domain-containing protein. (474 aa)
	LOC108898754	C3H1-type domain-containing protein. (626 aa)
	LOC108878368	Uncharacterized protein. (536 aa)
	il10	Uncharacterized protein. (187 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (542 aa)
	ENSLCAP00010028729	Cytochrome P450, family 1, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family. (522 aa)
	GREM1	Gremlin. (182 aa)
	tnn	Uncharacterized protein. (1410 aa)
	LOC108889675	Uncharacterized protein. (529 aa)
	LOC108889624	Uncharacterized protein. (503 aa)
	vegfc	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (422 aa)
	LOC108882928	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (157 aa)
	LOC108890315	Uncharacterized protein. (290 aa)
	LOC108875572	Uncharacterized protein. (536 aa)
	btg1	Uncharacterized protein. (182 aa)
	Xbp1	BZIP domain-containing protein. (264 aa)
	ENSLCAP00010033701	Si:ch73-334d15.2. (168 aa)
	nfe2l2	BZIP domain-containing protein. (612 aa)
	sp1	Uncharacterized protein. (714 aa)
	serpine1	SERPIN domain-containing protein; Belongs to the serpin family. (391 aa)
	hspb1	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (203 aa)
	sirt6	Deacetylase sirtuin-type domain-containing protein. (351 aa)
	ENSLCAP00010038402	Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family. (147 aa)
	igf2	Insulin-like growth factor II. (215 aa)
	LOC108897500	Uncharacterized protein. (168 aa)
	ENSLCAP00010039598	Uncharacterized protein. (133 aa)
	Sfrp2	Secreted frizzled-related protein 2. (284 aa)
	LOC108876301	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (591 aa)
	fgf1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (152 aa)
	gab1	PH domain-containing protein. (758 aa)
	ENSLCAP00010042788	Integrin beta; Belongs to the integrin beta chain family. (752 aa)
	Vegfb	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (147 aa)
	ENSLCAP00010044240	SAM domain-containing protein. (360 aa)
	ENSLCAP00010044639	Uncharacterized protein. (190 aa)
	LOC108892573	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (207 aa)
	ENSLCAP00010045301	Cholinergic receptor, nicotinic, alpha 7 (neuronal). (510 aa)
	LOC108886611	Uncharacterized protein. (389 aa)
	LOC108895960	Uncharacterized protein. (341 aa)
	ENSLCAP00010046255	Uncharacterized protein. (315 aa)
	LOC108888850	Uncharacterized protein. (535 aa)
	LOC108889675-2	Neuronal acetylcholine receptor subunit alpha-7-like. (529 aa)
	LOC108878374	Interleukin-1. (278 aa)
	LOC108886373	Uncharacterized protein. (868 aa)
	c5	Uncharacterized protein. (1688 aa)
	DDAH1	Uncharacterized protein. (282 aa)
	LOC108877025	Uncharacterized protein; Belongs to the peptidase C1 family. (331 aa)
	ENSLCAP00010053086	SERPIN domain-containing protein; Belongs to the serpin family. (383 aa)
	ENSLCAP00010053341	Apelin receptor a; Belongs to the G-protein coupled receptor 1 family. (359 aa)
	Mydgf	Myeloid-derived growth factor. (167 aa)
	ENSLCAP00010053976	Uncharacterized protein. (294 aa)
	LOC108885935	Uncharacterized protein. (693 aa)
	ENSLCAP00010054907	TNFR-Cys domain-containing protein. (380 aa)

Your Current Organism:

Lates calcarifer

NCBI taxonomy Id: 8187
Other names: Asian seabass, Holocentrus calcarifer, L. calcarifer, barramundi, barramundi perch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CXCR3	LOC108878374	ENSLCAP00010000151	ENSLCAP00010051161	C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	Interleukin-1.	0.530
CXCR3	il10	ENSLCAP00010000151	ENSLCAP00010026670	C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.470
ENSLCAP00010002403	ENSLCAP00010008602	ENSLCAP00010002403	ENSLCAP00010008602	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins.	Junction plakoglobin a.	0.873
ENSLCAP00010002403	ENSLCAP00010021275	ENSLCAP00010002403	ENSLCAP00010021275	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins.	Uncharacterized protein.	0.873
ENSLCAP00010002403	cd34	ENSLCAP00010002403	ENSLCAP00010019985	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins.	Uncharacterized protein.	0.615
ENSLCAP00010005004	LOC108882928	ENSLCAP00010005004	ENSLCAP00010032682	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.510
ENSLCAP00010005004	fgf1	ENSLCAP00010005004	ENSLCAP00010042300	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.510
ENSLCAP00010008602	ENSLCAP00010002403	ENSLCAP00010008602	ENSLCAP00010002403	Junction plakoglobin a.	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins.	0.873
ENSLCAP00010021275	ENSLCAP00010002403	ENSLCAP00010021275	ENSLCAP00010002403	Uncharacterized protein.	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins.	0.873
ENSLCAP00010033701	LOC108897500	ENSLCAP00010033701	ENSLCAP00010038592	Si:ch73-334d15.2.	Uncharacterized protein.	0.598
ENSLCAP00010038402	LOC108886096	ENSLCAP00010038402	ENSLCAP00010007210	Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.947
ENSLCAP00010038402	LOC108892573	ENSLCAP00010038402	ENSLCAP00010044954	Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.473
ENSLCAP00010042788	cd34	ENSLCAP00010042788	ENSLCAP00010019985	Integrin beta; Belongs to the integrin beta chain family.	Uncharacterized protein.	0.405
ENSLCAP00010042788	tnn	ENSLCAP00010042788	ENSLCAP00010030232	Integrin beta; Belongs to the integrin beta chain family.	Uncharacterized protein.	0.459
ENSLCAP00010053086	LOC108896747	ENSLCAP00010053086	ENSLCAP00010019044	SERPIN domain-containing protein; Belongs to the serpin family.	Uncharacterized protein.	0.469
ENSLCAP00010053341	LOC108879894	ENSLCAP00010053341	ENSLCAP00010011567	Apelin receptor a; Belongs to the G-protein coupled receptor 1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.906
ENSLCAP00010054907	LOC108878374	ENSLCAP00010054907	ENSLCAP00010051161	TNFR-Cys domain-containing protein.	Interleukin-1.	0.639
ENSLCAP00010054907	il10	ENSLCAP00010054907	ENSLCAP00010026670	TNFR-Cys domain-containing protein.	Uncharacterized protein.	0.606
LOC108873688	LOC108882928	ENSLCAP00010008961	ENSLCAP00010032682	PH domain-containing protein.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.456
LOC108873688	fgf1	ENSLCAP00010008961	ENSLCAP00010042300	PH domain-containing protein.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.456