(16 nodes) Positive regulation of isotype switching network (Lates calcarifer)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

gene neighborhood

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Your Input:
	ENSLCAP00010029854	ATPase family, AAA domain containing 5a. (1490 aa)
	ENSLCAP00010021743	annotation not available (217 aa)
	LOC108875247	Uncharacterized protein. (273 aa)
	tbx21	T-box_assoc domain-containing protein. (621 aa)
	Msh2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (908 aa)
	ENSLCAP00010043553	Replication timing regulatory factor 1. (2186 aa)
	hmces	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (344 aa)
	Mlh1	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (716 aa)
	ENSLCAP00010054907	TNFR-Cys domain-containing protein. (380 aa)
	EXOSC3	KH_dom_type_1 domain-containing protein. (285 aa)
	ENSLCAP00010001230	Nuclear receptor binding SET domain protein 2. (1162 aa)
	ENSLCAP00010008081	Tumor protein p53 binding protein, 1. (1495 aa)
	kmt5b	SET domain-containing protein. (865 aa)
	LOC108880626	SET domain-containing protein. (2103 aa)
	Ptprc	Protein tyrosine phosphatase, receptor type, C. (856 aa)
	LOC108876160	Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)

Your Current Organism:

Lates calcarifer

NCBI taxonomy Id: 8187
Other names: Asian seabass, Holocentrus calcarifer, L. calcarifer, barramundi, barramundi perch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSLCAP00010001230	ENSLCAP00010008081	ENSLCAP00010001230	ENSLCAP00010008081	Nuclear receptor binding SET domain protein 2.	Tumor protein p53 binding protein, 1.	0.719
ENSLCAP00010001230	ENSLCAP00010043553	ENSLCAP00010001230	ENSLCAP00010043553	Nuclear receptor binding SET domain protein 2.	Replication timing regulatory factor 1.	0.568
ENSLCAP00010008081	ENSLCAP00010001230	ENSLCAP00010008081	ENSLCAP00010001230	Tumor protein p53 binding protein, 1.	Nuclear receptor binding SET domain protein 2.	0.719
ENSLCAP00010008081	ENSLCAP00010043553	ENSLCAP00010008081	ENSLCAP00010043553	Tumor protein p53 binding protein, 1.	Replication timing regulatory factor 1.	0.811
ENSLCAP00010008081	LOC108875247	ENSLCAP00010008081	ENSLCAP00010030126	Tumor protein p53 binding protein, 1.	Uncharacterized protein.	0.415
ENSLCAP00010008081	LOC108880626	ENSLCAP00010008081	ENSLCAP00010010886	Tumor protein p53 binding protein, 1.	SET domain-containing protein.	0.478
ENSLCAP00010008081	kmt5b	ENSLCAP00010008081	ENSLCAP00010009187	Tumor protein p53 binding protein, 1.	SET domain-containing protein.	0.478
ENSLCAP00010029854	Msh2	ENSLCAP00010029854	ENSLCAP00010038465	ATPase family, AAA domain containing 5a.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.468
ENSLCAP00010043553	ENSLCAP00010001230	ENSLCAP00010043553	ENSLCAP00010001230	Replication timing regulatory factor 1.	Nuclear receptor binding SET domain protein 2.	0.568
ENSLCAP00010043553	ENSLCAP00010008081	ENSLCAP00010043553	ENSLCAP00010008081	Replication timing regulatory factor 1.	Tumor protein p53 binding protein, 1.	0.811
ENSLCAP00010043553	LOC108875247	ENSLCAP00010043553	ENSLCAP00010030126	Replication timing regulatory factor 1.	Uncharacterized protein.	0.420
ENSLCAP00010054907	Ptprc	ENSLCAP00010054907	ENSLCAP00010014891	TNFR-Cys domain-containing protein.	Protein tyrosine phosphatase, receptor type, C.	0.492
LOC108875247	ENSLCAP00010008081	ENSLCAP00010030126	ENSLCAP00010008081	Uncharacterized protein.	Tumor protein p53 binding protein, 1.	0.415
LOC108875247	ENSLCAP00010043553	ENSLCAP00010030126	ENSLCAP00010043553	Uncharacterized protein.	Replication timing regulatory factor 1.	0.420
LOC108876160	tbx21	ENSLCAP00010015620	ENSLCAP00010030437	Transforming growth factor beta; Belongs to the TGF-beta family.	T-box_assoc domain-containing protein.	0.406
LOC108880626	ENSLCAP00010008081	ENSLCAP00010010886	ENSLCAP00010008081	SET domain-containing protein.	Tumor protein p53 binding protein, 1.	0.478
Mlh1	Msh2	ENSLCAP00010048466	ENSLCAP00010038465	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.998
Msh2	ENSLCAP00010029854	ENSLCAP00010038465	ENSLCAP00010029854	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	ATPase family, AAA domain containing 5a.	0.468
Msh2	Mlh1	ENSLCAP00010038465	ENSLCAP00010048466	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	0.998
Ptprc	ENSLCAP00010054907	ENSLCAP00010014891	ENSLCAP00010054907	Protein tyrosine phosphatase, receptor type, C.	TNFR-Cys domain-containing protein.	0.492