(49 nodes) Positive regulation of mitotic cell cycle network (Lates calcarifer)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	mblac1	Lactamase_B domain-containing protein. (245 aa)
	Cdc25b	Rhodanese domain-containing protein. (385 aa)
	Brca2	Breast cancer 2, early onset. (2872 aa)
	LOC108897621	Uncharacterized protein. (179 aa)
	CUL3	CULLIN_2 domain-containing protein; Belongs to the cullin family. (766 aa)
	nsmce2	SP-RING-type domain-containing protein. (230 aa)
	Cdt1	Chromatin licensing and DNA replication factor 1. (482 aa)
	ccnd1	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (292 aa)
	poldip2	ApaG domain-containing protein. (388 aa)
	sass6	Uncharacterized protein. (592 aa)
	Mad2l1bp	MAD2L1 binding protein. (257 aa)
	mtbp	Uncharacterized protein. (883 aa)
	ENSLCAP00010006686	Lysine (K)-specific methyltransferase 2E. (1585 aa)
	LOC108886219	Uncharacterized protein; Belongs to the cyclin family. (294 aa)
	LSM10	LSM10, U7 small nuclear RNA associated. (124 aa)
	stox1	Stork_head domain-containing protein. (1112 aa)
	cdc23	Uncharacterized protein. (600 aa)
	Lsm11	LSM11, U7 small nuclear RNA associated. (347 aa)
	Ppp1r10	Protein phosphatase 1, regulatory subunit 10. (804 aa)
	AIF1	Allograft inflammatory factor 1. (208 aa)
	ttl	Uncharacterized protein. (409 aa)
	Cul4a	Cullin 4A; Belongs to the cullin family. (751 aa)
	anapc11	RING-type domain-containing protein. (84 aa)
	Mecp2	Methyl CpG binding protein 2. (1030 aa)
	Cdca5	Uncharacterized protein. (303 aa)
	rad51c	RECA_2 domain-containing protein. (381 aa)
	plrg1	WD_REPEATS_REGION domain-containing protein. (521 aa)
	cdc27	Uncharacterized protein. (808 aa)
	anapc5	Uncharacterized protein. (773 aa)
	LOC108886600	CULLIN_2 domain-containing protein; Belongs to the cullin family. (771 aa)
	nkx3-1	Homeobox domain-containing protein. (195 aa)
	anapc7	Uncharacterized protein. (574 aa)
	LOC108891569	Uncharacterized protein. (852 aa)
	LOC108891568	Uncharacterized protein. (686 aa)
	Stil	Uncharacterized protein. (873 aa)
	rb1	Uncharacterized protein. (913 aa)
	ENSLCAP00010054323	Cullin 4B; Belongs to the cullin family. (916 aa)
	LOC108879779-2	G1/S-specific cyclin-D1-like. (293 aa)
	ube2c	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (174 aa)
	LOC108879779	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (293 aa)
	CPSF3	Uncharacterized protein. (690 aa)
	Adam17	ADAM metallopeptidase domain 17a. (781 aa)
	Lgmn	Legumain. (425 aa)
	cdc7	Protein kinase domain-containing protein. (610 aa)
	LOC108901859	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (366 aa)
	Rptor	Regulatory associated protein of MTOR, complex 1. (1362 aa)
	cdc16	TPR_REGION domain-containing protein. (620 aa)
	rad51b	RECA_2 domain-containing protein. (386 aa)
	CCDC57	Coiled-coil domain containing 57. (704 aa)

Your Current Organism:

Lates calcarifer

NCBI taxonomy Id: 8187
Other names: Asian seabass, Holocentrus calcarifer, L. calcarifer, barramundi, barramundi perch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Adam17	LOC108891569	ENSLCAP00010049126	ENSLCAP00010055979	ADAM metallopeptidase domain 17a.	Uncharacterized protein.	0.901
Brca2	rad51b	ENSLCAP00010030231	ENSLCAP00010025561	Breast cancer 2, early onset.	RECA_2 domain-containing protein.	0.965
Brca2	rad51c	ENSLCAP00010030231	ENSLCAP00010038365	Breast cancer 2, early onset.	RECA_2 domain-containing protein.	0.997
Brca2	sass6	ENSLCAP00010030231	ENSLCAP00010002802	Breast cancer 2, early onset.	Uncharacterized protein.	0.404
CPSF3	LOC108891568	ENSLCAP00010049557	ENSLCAP00010055928	Uncharacterized protein.	Uncharacterized protein.	0.900
CPSF3	LSM10	ENSLCAP00010049557	ENSLCAP00010008406	Uncharacterized protein.	LSM10, U7 small nuclear RNA associated.	0.835
CPSF3	Lsm11	ENSLCAP00010049557	ENSLCAP00010015037	Uncharacterized protein.	LSM11, U7 small nuclear RNA associated.	0.527
CPSF3	cdc23	ENSLCAP00010049557	ENSLCAP00010014168	Uncharacterized protein.	Uncharacterized protein.	0.408
CUL3	Cdt1	ENSLCAP00010033441	ENSLCAP00010000317	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Chromatin licensing and DNA replication factor 1.	0.448
CUL3	LOC108879779	ENSLCAP00010033441	ENSLCAP00010049677	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.548
CUL3	LOC108879779-2	ENSLCAP00010033441	ENSLCAP00010053877	CULLIN_2 domain-containing protein; Belongs to the cullin family.	G1/S-specific cyclin-D1-like.	0.548
CUL3	LOC108886219	ENSLCAP00010033441	ENSLCAP00010006777	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Uncharacterized protein; Belongs to the cyclin family.	0.548
CUL3	LOC108886600	ENSLCAP00010033441	ENSLCAP00010045383	CULLIN_2 domain-containing protein; Belongs to the cullin family.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.900
CUL3	LOC108901859	ENSLCAP00010033441	ENSLCAP00010022378	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.548
CUL3	ccnd1	ENSLCAP00010033441	ENSLCAP00010000381	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.548
CUL3	rb1	ENSLCAP00010033441	ENSLCAP00010055000	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Uncharacterized protein.	0.544
CUL3	ube2c	ENSLCAP00010033441	ENSLCAP00010050259	CULLIN_2 domain-containing protein; Belongs to the cullin family.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.489
Cdc25b	cdc27	ENSLCAP00010028000	ENSLCAP00010043059	Rhodanese domain-containing protein.	Uncharacterized protein.	0.445
Cdca5	Cdt1	ENSLCAP00010046624	ENSLCAP00010000317	Uncharacterized protein.	Chromatin licensing and DNA replication factor 1.	0.773
Cdca5	ube2c	ENSLCAP00010046624	ENSLCAP00010050259	Uncharacterized protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.693