(66 nodes) Negative regulation of inflammatory response network (Lates calcarifer)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSLCAP00010045493	Uncharacterized protein. (363 aa)
	LOC108892854	Ig-like domain-containing protein. (325 aa)
	ENSLCAP00010045517	Ig-like domain-containing protein. (241 aa)
	NT5E	Uncharacterized protein; Belongs to the 5'-nucleotidase family. (576 aa)
	ENSLCAP00010046779	Cylindromatosis (turban tumor syndrome), like; Belongs to the peptidase C19 family. (520 aa)
	psmb4	Proteasome subunit beta; Belongs to the peptidase T1B family. (262 aa)
	ENSLCAP00010047467	Nuclear receptor subfamily 1, group d, member 1. (549 aa)
	ENSLCAP00010048282	Prostaglandin E receptor 4 (subtype EP4) c; Belongs to the G-protein coupled receptor 1 family. (301 aa)
	ENSLCAP00010050095	Uncharacterized protein. (723 aa)
	ENSLCAP00010051369	Nuclear receptor subfamily 1, group D, member 4a. (575 aa)
	LOC108876582	Uncharacterized protein. (128 aa)
	ENSLCAP00010054078	NACHT domain-containing protein. (935 aa)
	rb1	Uncharacterized protein. (913 aa)
	metrnl	Uncharacterized protein. (286 aa)
	socs3	Uncharacterized protein. (205 aa)
	ENSLCAP00010058347	Uncharacterized protein. (129 aa)
	LOC108889221	Uncharacterized protein. (605 aa)
	Mvk	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (392 aa)
	ENSLCAP00010002403	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (752 aa)
	LOC108882618	Uncharacterized protein. (512 aa)
	wfdc1	WAP domain-containing protein. (209 aa)
	CCN3	Cellular communication network factor 3. (357 aa)
	LOC108902980	Phospholipase A(2). (153 aa)
	nlrx1	NACHT domain-containing protein. (984 aa)
	Nr1d2	Nuclear receptor subfamily 1, group D, member 2b. (591 aa)
	Lpcat3	Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (460 aa)
	LOC108882313	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (443 aa)
	proc	Uncharacterized protein. (442 aa)
	otulin	Uncharacterized protein. (744 aa)
	il12b	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (353 aa)
	LOC108900852	Uncharacterized protein. (506 aa)
	ENSLCAP00010016433	Uncharacterized protein. (693 aa)
	PPARA	Uncharacterized protein. (473 aa)
	vps35	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (798 aa)
	Sharpin	SHANK-associated RH domain interacting protein. (435 aa)
	ENSLCAP00010022688	Aconitate decarboxylase 1. (439 aa)
	ENSLCAP00010024056	Tumor necrosis factor receptor superfamily, member 1a. (440 aa)
	smpdl3b	Metallophos domain-containing protein. (486 aa)
	Cunh5orf30	Zgc:194281. (213 aa)
	gpr17	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (339 aa)
	rabgef1	Uncharacterized protein. (511 aa)
	LOC108876107	Uncharacterized protein. (228 aa)
	ENSLCAP00010026213	Growth hormone secretagogue receptor b; Belongs to the G-protein coupled receptor 1 family. (386 aa)
	il10	Uncharacterized protein. (187 aa)
	ENSLCAP00010026719	Leucine rich repeat and fibronectin type III domain containing 5b. (738 aa)
	ENSLCAP00010026940	Tumor necrosis factor, alpha-induced protein 3. (777 aa)
	LOC108882359	Ig-like domain-containing protein. (878 aa)
	FFAR4	G_PROTEIN_RECEP_F1_2 domain-containing protein. (352 aa)
	ENSLCAP00010031816	Granulin a. (787 aa)
	ENSLCAP00010032129	Immunoresponsive gene 1, like. (448 aa)
	fndc4	Fibronectin type-III domain-containing protein. (220 aa)
	grn	Uncharacterized protein. (837 aa)
	nr1h4	Uncharacterized protein. (485 aa)
	Cyld	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family. (920 aa)
	mfhas1	Roc domain-containing protein. (1029 aa)
	LOC108881433	Motilin_assoc domain-containing protein. (107 aa)
	LOC108882246	Uncharacterized protein; Belongs to the 5'-nucleotidase family. (584 aa)
	dusp10	Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (472 aa)
	ENSLCAP00010041452	Interleukin 22 receptor, alpha 2. (215 aa)
	LOC108877701	Uncharacterized protein. (299 aa)
	LOC108885597	Uncharacterized protein. (712 aa)
	tnfaip6	Uncharacterized protein. (263 aa)
	LOC108893693	Uncharacterized protein. (888 aa)
	CST7	Cystatin F. (133 aa)
	ptger4	G_PROTEIN_RECEP_F1_2 domain-containing protein. (450 aa)
	PPARG	Uncharacterized protein. (552 aa)

Your Current Organism:

Lates calcarifer

NCBI taxonomy Id: 8187
Other names: Asian seabass, Holocentrus calcarifer, L. calcarifer, barramundi, barramundi perch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cyld	ENSLCAP00010024056	ENSLCAP00010034631	ENSLCAP00010024056	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family.	Tumor necrosis factor receptor superfamily, member 1a.	0.926
Cyld	Sharpin	ENSLCAP00010034631	ENSLCAP00010019882	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family.	SHANK-associated RH domain interacting protein.	0.632
ENSLCAP00010024056	Cyld	ENSLCAP00010024056	ENSLCAP00010034631	Tumor necrosis factor receptor superfamily, member 1a.	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family.	0.926
ENSLCAP00010024056	ENSLCAP00010026940	ENSLCAP00010024056	ENSLCAP00010026940	Tumor necrosis factor receptor superfamily, member 1a.	Tumor necrosis factor, alpha-induced protein 3.	0.980
ENSLCAP00010024056	ENSLCAP00010046779	ENSLCAP00010024056	ENSLCAP00010046779	Tumor necrosis factor receptor superfamily, member 1a.	Cylindromatosis (turban tumor syndrome), like; Belongs to the peptidase C19 family.	0.926
ENSLCAP00010024056	LOC108885597	ENSLCAP00010024056	ENSLCAP00010042082	Tumor necrosis factor receptor superfamily, member 1a.	Uncharacterized protein.	0.926
ENSLCAP00010024056	Sharpin	ENSLCAP00010024056	ENSLCAP00010019882	Tumor necrosis factor receptor superfamily, member 1a.	SHANK-associated RH domain interacting protein.	0.969
ENSLCAP00010024056	il10	ENSLCAP00010024056	ENSLCAP00010026670	Tumor necrosis factor receptor superfamily, member 1a.	Uncharacterized protein.	0.738
ENSLCAP00010026213	LOC108881433	ENSLCAP00010026213	ENSLCAP00010038847	Growth hormone secretagogue receptor b; Belongs to the G-protein coupled receptor 1 family.	Motilin_assoc domain-containing protein.	0.997
ENSLCAP00010026940	ENSLCAP00010024056	ENSLCAP00010026940	ENSLCAP00010024056	Tumor necrosis factor, alpha-induced protein 3.	Tumor necrosis factor receptor superfamily, member 1a.	0.980
ENSLCAP00010026940	Sharpin	ENSLCAP00010026940	ENSLCAP00010019882	Tumor necrosis factor, alpha-induced protein 3.	SHANK-associated RH domain interacting protein.	0.508
ENSLCAP00010046779	ENSLCAP00010024056	ENSLCAP00010046779	ENSLCAP00010024056	Cylindromatosis (turban tumor syndrome), like; Belongs to the peptidase C19 family.	Tumor necrosis factor receptor superfamily, member 1a.	0.926
ENSLCAP00010046779	Sharpin	ENSLCAP00010046779	ENSLCAP00010019882	Cylindromatosis (turban tumor syndrome), like; Belongs to the peptidase C19 family.	SHANK-associated RH domain interacting protein.	0.632
ENSLCAP00010047467	LOC108889221	ENSLCAP00010047467	ENSLCAP00010058550	Nuclear receptor subfamily 1, group d, member 1.	Uncharacterized protein.	0.423
ENSLCAP00010047467	Nr1d2	ENSLCAP00010047467	ENSLCAP00010006111	Nuclear receptor subfamily 1, group d, member 1.	Nuclear receptor subfamily 1, group D, member 2b.	0.428
ENSLCAP00010051369	LOC108889221	ENSLCAP00010051369	ENSLCAP00010058550	Nuclear receptor subfamily 1, group D, member 4a.	Uncharacterized protein.	0.419
ENSLCAP00010051369	Nr1d2	ENSLCAP00010051369	ENSLCAP00010006111	Nuclear receptor subfamily 1, group D, member 4a.	Nuclear receptor subfamily 1, group D, member 2b.	0.418
LOC108876107	il10	ENSLCAP00010026164	ENSLCAP00010026670	Uncharacterized protein.	Uncharacterized protein.	0.427
LOC108876107	socs3	ENSLCAP00010026164	ENSLCAP00010057186	Uncharacterized protein.	Uncharacterized protein.	0.902
LOC108881433	ENSLCAP00010026213	ENSLCAP00010038847	ENSLCAP00010026213	Motilin_assoc domain-containing protein.	Growth hormone secretagogue receptor b; Belongs to the G-protein coupled receptor 1 family.	0.997