(41 nodes) Regulation of cytosolic calcium ion concentration network (Lates calcarifer)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	ENSLCAP00010036900	Transient receptor potential cation channel, subfamily C, member 7b; Belongs to the transient receptor (TC 1.A.4) family. (840 aa)
	P2RY4	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (362 aa)
	p2rx1	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (421 aa)
	ENSLCAP00010042411	Glutamate receptor, metabotropic 1b. (1154 aa)
	LOC108902790	ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (1116 aa)
	Grm5	Glutamate receptor, metabotropic 5b. (1234 aa)
	ENSLCAP00010050118	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1247 aa)
	Trpc4	Transient receptor potential cation channel, subfamily C, member 4a; Belongs to the transient receptor (TC 1.A.4) family. (986 aa)
	LOC108877193	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (623 aa)
	ENSLCAP00010054314	Si:ch211-132f19.7; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (844 aa)
	LOC108893141	Uncharacterized protein. (1039 aa)
	ENSLCAP00010055744	Glutamate receptor, metabotropic 5a. (1205 aa)
	ENSLCAP00010056777	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (150 aa)
	CAV3-2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (158 aa)
	ENSLCAP00010057066	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (363 aa)
	LOC108885345	Asp-B-Hydro_N domain-containing protein. (215 aa)
	ENSLCAP00010058954	Uncharacterized protein. (281 aa)
	hcrtr2	G_PROTEIN_RECEP_F1_2 domain-containing protein. (423 aa)
	SLC8B1	Solute carrier family 8 member B1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (556 aa)
	LOC108887604	Uncharacterized protein. (272 aa)
	LOC108877733	Uncharacterized protein. (276 aa)
	SCGN	Uncharacterized protein. (272 aa)
	ENSLCAP00010007626	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1237 aa)
	TRPC6	Transient receptor potential cation channel, subfamily C, member 6b; Belongs to the transient receptor (TC 1.A.4) family. (838 aa)
	ENSLCAP00010010884	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1188 aa)
	adcy8	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1240 aa)
	LOC108880909	G_PROTEIN_RECEP_F3_4 domain-containing protein. (1129 aa)
	slc35g1	Uncharacterized protein. (418 aa)
	trpc1	Uncharacterized protein; Belongs to the transient receptor (TC 1.A.4) family. (796 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (111 aa)
	TRPC6-2	ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (844 aa)
	LOC108895615	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1184 aa)
	ENSLCAP00010024138	Calbindin 1. (196 aa)
	tmem178a	Uncharacterized protein. (339 aa)
	CALB2	Uncharacterized protein. (271 aa)
	ENSLCAP00010029368	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (623 aa)
	tmem64	Uncharacterized protein. (352 aa)
	LOC108876021	ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (917 aa)
	ENSLCAP00010032729	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1251 aa)
	Atp2b3	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1329 aa)
	ENSLCAP00010035882	Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (304 aa)

Your Current Organism:

Lates calcarifer

NCBI taxonomy Id: 8187
Other names: Asian seabass, Holocentrus calcarifer, L. calcarifer, barramundi, barramundi perch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Atp2b3	ENSLCAP00010010884	ENSLCAP00010033193	ENSLCAP00010010884	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.901
Atp2b3	ENSLCAP00010032729	ENSLCAP00010033193	ENSLCAP00010032729	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.901
CAV3	CAV3-2	ENSLCAP00010020110	ENSLCAP00010056785	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.483
CAV3-2	CAV3	ENSLCAP00010056785	ENSLCAP00010020110	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.483
CAV3-2	ENSLCAP00010056777	ENSLCAP00010056785	ENSLCAP00010056777	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.544
CAV3-2	trpc1	ENSLCAP00010056785	ENSLCAP00010019497	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Uncharacterized protein; Belongs to the transient receptor (TC 1.A.4) family.	0.577
ENSLCAP00010010884	Atp2b3	ENSLCAP00010010884	ENSLCAP00010033193	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.901
ENSLCAP00010010884	ENSLCAP00010032729	ENSLCAP00010010884	ENSLCAP00010032729	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.901
ENSLCAP00010029368	LOC108877193	ENSLCAP00010029368	ENSLCAP00010053944	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.900
ENSLCAP00010032729	Atp2b3	ENSLCAP00010032729	ENSLCAP00010033193	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.901
ENSLCAP00010032729	ENSLCAP00010010884	ENSLCAP00010032729	ENSLCAP00010010884	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.901
ENSLCAP00010036900	trpc1	ENSLCAP00010036900	ENSLCAP00010019497	Transient receptor potential cation channel, subfamily C, member 7b; Belongs to the transient receptor (TC 1.A.4) family.	Uncharacterized protein; Belongs to the transient receptor (TC 1.A.4) family.	0.512
ENSLCAP00010042411	LOC108880909	ENSLCAP00010042411	ENSLCAP00010016598	Glutamate receptor, metabotropic 1b.	G_PROTEIN_RECEP_F3_4 domain-containing protein.	0.905
ENSLCAP00010056777	CAV3-2	ENSLCAP00010056777	ENSLCAP00010056785	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.544
ENSLCAP00010056777	trpc1	ENSLCAP00010056777	ENSLCAP00010019497	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Uncharacterized protein; Belongs to the transient receptor (TC 1.A.4) family.	0.446
LOC108876021	trpc1	ENSLCAP00010030836	ENSLCAP00010019497	ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family.	Uncharacterized protein; Belongs to the transient receptor (TC 1.A.4) family.	0.662
LOC108877193	ENSLCAP00010029368	ENSLCAP00010053944	ENSLCAP00010029368	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.900
LOC108880909	ENSLCAP00010042411	ENSLCAP00010016598	ENSLCAP00010042411	G_PROTEIN_RECEP_F3_4 domain-containing protein.	Glutamate receptor, metabotropic 1b.	0.905
LOC108893141	trpc1	ENSLCAP00010055050	ENSLCAP00010019497	Uncharacterized protein.	Uncharacterized protein; Belongs to the transient receptor (TC 1.A.4) family.	0.489
LOC108902790	trpc1	ENSLCAP00010042420	ENSLCAP00010019497	ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family.	Uncharacterized protein; Belongs to the transient receptor (TC 1.A.4) family.	0.659