node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSLCAP00010004739 | ENSLCAP00010040277 | ENSLCAP00010004739 | ENSLCAP00010040277 | PHD-type domain-containing protein. | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | 0.631 |
ENSLCAP00010014176 | ENSLCAP00010040277 | ENSLCAP00010014176 | ENSLCAP00010040277 | Lysine (K)-specific demethylase 4B. | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | 0.631 |
ENSLCAP00010030113 | dnmt1 | ENSLCAP00010030113 | ENSLCAP00010056006 | Uncharacterized protein. | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | 0.580 |
ENSLCAP00010032564 | ENSLCAP00010040277 | ENSLCAP00010032564 | ENSLCAP00010040277 | Alpha thalassemia/mental retardation syndrome X-linked homolog (human). | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | 0.408 |
ENSLCAP00010032564 | Mecp2 | ENSLCAP00010032564 | ENSLCAP00010037882 | Alpha thalassemia/mental retardation syndrome X-linked homolog (human). | Methyl CpG binding protein 2. | 0.699 |
ENSLCAP00010032564 | brca1 | ENSLCAP00010032564 | ENSLCAP00010006276 | Alpha thalassemia/mental retardation syndrome X-linked homolog (human). | Uncharacterized protein. | 0.439 |
ENSLCAP00010032564 | dnmt1 | ENSLCAP00010032564 | ENSLCAP00010056006 | Alpha thalassemia/mental retardation syndrome X-linked homolog (human). | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | 0.408 |
ENSLCAP00010039432 | ENSLCAP00010040277 | ENSLCAP00010039432 | ENSLCAP00010040277 | Euchromatic histone-lysine N-methyltransferase 2. | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | 0.550 |
ENSLCAP00010039432 | Sirt1 | ENSLCAP00010039432 | ENSLCAP00010015909 | Euchromatic histone-lysine N-methyltransferase 2. | Deacetylase sirtuin-type domain-containing protein. | 0.477 |
ENSLCAP00010039432 | dnmt1 | ENSLCAP00010039432 | ENSLCAP00010056006 | Euchromatic histone-lysine N-methyltransferase 2. | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | 0.582 |
ENSLCAP00010040277 | ENSLCAP00010004739 | ENSLCAP00010040277 | ENSLCAP00010004739 | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | PHD-type domain-containing protein. | 0.631 |
ENSLCAP00010040277 | ENSLCAP00010014176 | ENSLCAP00010040277 | ENSLCAP00010014176 | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | Lysine (K)-specific demethylase 4B. | 0.631 |
ENSLCAP00010040277 | ENSLCAP00010032564 | ENSLCAP00010040277 | ENSLCAP00010032564 | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | Alpha thalassemia/mental retardation syndrome X-linked homolog (human). | 0.408 |
ENSLCAP00010040277 | ENSLCAP00010039432 | ENSLCAP00010040277 | ENSLCAP00010039432 | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | Euchromatic histone-lysine N-methyltransferase 2. | 0.550 |
ENSLCAP00010040277 | ENSLCAP00010051031 | ENSLCAP00010040277 | ENSLCAP00010051031 | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | Alpha thalassemia/mental retardation syndrome X-linked, like. | 0.408 |
ENSLCAP00010040277 | ENSLCAP00010058195 | ENSLCAP00010040277 | ENSLCAP00010058195 | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | Euchromatic histone-lysine N-methyltransferase 1a. | 0.550 |
ENSLCAP00010040277 | ENSLCAP00010059417 | ENSLCAP00010040277 | ENSLCAP00010059417 | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | Lysine (K)-specific demethylase 4C. | 0.631 |
ENSLCAP00010040277 | LOC108883687 | ENSLCAP00010040277 | ENSLCAP00010048244 | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | Uncharacterized protein. | 0.631 |
ENSLCAP00010040277 | LOC108889015 | ENSLCAP00010040277 | ENSLCAP00010048420 | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | Uncharacterized protein. | 0.550 |
ENSLCAP00010040277 | Mecp2 | ENSLCAP00010040277 | ENSLCAP00010037882 | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. | Methyl CpG binding protein 2. | 0.565 |