(44 nodes) Cellular response to cAMP network (Lates calcarifer)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSLCAP00010049166	Rap guanine nucleotide exchange factor (GEF) 2. (1603 aa)
	LOC108886373	Uncharacterized protein. (868 aa)
	ENSLCAP00010051319	N-terminal Ras-GEF domain-containing protein. (688 aa)
	LOC108885900	Cyclic nucleotide-binding domain-containing protein. (1521 aa)
	pik3cg	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1122 aa)
	gata1	Uncharacterized protein. (365 aa)
	LOC108884757	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1107 aa)
	aqp8	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (260 aa)
	ENSLCAP00010048677	Hyperpolarization activated cyclic nucleotide-gated potassium channel 3. (332 aa)
	LOC108890780	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (260 aa)
	LOC108898703	N-acetyltransferase domain-containing protein. (226 aa)
	rapgef1	Uncharacterized protein. (1100 aa)
	ENSLCAP00010003849	Uncharacterized protein. (120 aa)
	ENSLCAP00010004102	AKAP7_NLS domain-containing protein. (403 aa)
	ENSLCAP00010005348	Arylalkylamine N-acetyltransferase 2. (209 aa)
	ENSLCAP00010005778	annotation not available (209 aa)
	HCN2	Cyclic nucleotide-binding domain-containing protein. (1065 aa)
	LOC108884107	Uncharacterized protein. (185 aa)
	ENSLCAP00010007608	Aquaporin 1a (Colton blood group), tandem duplicate 2; Belongs to the MIP/aquaporin (TC 1.A.8) family. (277 aa)
	LOC108883341	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (265 aa)
	LOC108883342	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (280 aa)
	ENSLCAP00010008828	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
	ENSLCAP00010009815	Hyperpolarization activated cyclic nucleotide-gated potassium channel 1. (913 aa)
	wt1	Uncharacterized protein. (481 aa)
	ENSLCAP00010013012	Uncharacterized protein. (788 aa)
	ENSLCAP00010016697	Uncharacterized protein; Belongs to the potassium channel family. (657 aa)
	HCN4	Hyperpolarization activated cyclic nucleotide-gated potassium channel 4l. (821 aa)
	rap1b	Uncharacterized protein. (188 aa)
	LOC108886282	Uncharacterized protein; Belongs to the cytochrome P450 family. (559 aa)
	crhbp	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (323 aa)
	ENSLCAP00010026153	Eukaryotic elongation factor 2 kinase. (690 aa)
	LOC108879697	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (257 aa)
	ENSLCAP00010028729	Cytochrome P450, family 1, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family. (522 aa)
	LOC108883584	Cyclic nucleotide-binding domain-containing protein. (1161 aa)
	LOC108890490	Uncharacterized protein. (185 aa)
	ENSLCAP00010038111	Wilms tumor 1a. (443 aa)
	LOC108896860	Uncharacterized protein. (509 aa)
	LOC108887807	Uncharacterized protein; Belongs to the potassium channel family. (686 aa)
	ENSLCAP00010040277	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (854 aa)
	ENSLCAP00010040286	Hyperpolarization activated cyclic nucleotide-gated potassium channel 4. (1242 aa)
	ENSLCAP00010041366	GATA binding protein 1a. (416 aa)
	AANAT	N-acetyltransferase domain-containing protein. (202 aa)
	LOC108873031	Uncharacterized protein. (266 aa)
	LOC108897190	Uncharacterized protein. (275 aa)

Your Current Organism:

Lates calcarifer

NCBI taxonomy Id: 8187
Other names: Asian seabass, Holocentrus calcarifer, L. calcarifer, barramundi, barramundi perch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AANAT	ENSLCAP00010005348	ENSLCAP00010044202	ENSLCAP00010005348	N-acetyltransferase domain-containing protein.	Arylalkylamine N-acetyltransferase 2.	0.901
AANAT	LOC108898703	ENSLCAP00010044202	ENSLCAP00010000866	N-acetyltransferase domain-containing protein.	N-acetyltransferase domain-containing protein.	0.901
ENSLCAP00010003849	ENSLCAP00010016697	ENSLCAP00010003849	ENSLCAP00010016697	Uncharacterized protein.	Uncharacterized protein; Belongs to the potassium channel family.	0.816
ENSLCAP00010003849	LOC108887807	ENSLCAP00010003849	ENSLCAP00010039868	Uncharacterized protein.	Uncharacterized protein; Belongs to the potassium channel family.	0.816
ENSLCAP00010004102	ENSLCAP00010013012	ENSLCAP00010004102	ENSLCAP00010013012	AKAP7_NLS domain-containing protein.	Uncharacterized protein.	0.501
ENSLCAP00010005348	AANAT	ENSLCAP00010005348	ENSLCAP00010044202	Arylalkylamine N-acetyltransferase 2.	N-acetyltransferase domain-containing protein.	0.901
ENSLCAP00010005348	LOC108898703	ENSLCAP00010005348	ENSLCAP00010000866	Arylalkylamine N-acetyltransferase 2.	N-acetyltransferase domain-containing protein.	0.902
ENSLCAP00010007608	LOC108879697	ENSLCAP00010007608	ENSLCAP00010028077	Aquaporin 1a (Colton blood group), tandem duplicate 2; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.514
ENSLCAP00010007608	LOC108890780	ENSLCAP00010007608	ENSLCAP00010060412	Aquaporin 1a (Colton blood group), tandem duplicate 2; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.517
ENSLCAP00010007608	aqp8	ENSLCAP00010007608	ENSLCAP00010060409	Aquaporin 1a (Colton blood group), tandem duplicate 2; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.505
ENSLCAP00010013012	ENSLCAP00010004102	ENSLCAP00010013012	ENSLCAP00010004102	Uncharacterized protein.	AKAP7_NLS domain-containing protein.	0.501
ENSLCAP00010013012	LOC108886373	ENSLCAP00010013012	ENSLCAP00010051180	Uncharacterized protein.	Uncharacterized protein.	0.658
ENSLCAP00010013012	LOC108896860	ENSLCAP00010013012	ENSLCAP00010038712	Uncharacterized protein.	Uncharacterized protein.	0.501
ENSLCAP00010016697	ENSLCAP00010003849	ENSLCAP00010016697	ENSLCAP00010003849	Uncharacterized protein; Belongs to the potassium channel family.	Uncharacterized protein.	0.816
ENSLCAP00010016697	LOC108887807	ENSLCAP00010016697	ENSLCAP00010039868	Uncharacterized protein; Belongs to the potassium channel family.	Uncharacterized protein; Belongs to the potassium channel family.	0.903
ENSLCAP00010048677	HCN4	ENSLCAP00010048677	ENSLCAP00010017457	Hyperpolarization activated cyclic nucleotide-gated potassium channel 3.	Hyperpolarization activated cyclic nucleotide-gated potassium channel 4l.	0.896
ENSLCAP00010049166	LOC108884107	ENSLCAP00010049166	ENSLCAP00010006905	Rap guanine nucleotide exchange factor (GEF) 2.	Uncharacterized protein.	0.803
ENSLCAP00010049166	LOC108890490	ENSLCAP00010049166	ENSLCAP00010035702	Rap guanine nucleotide exchange factor (GEF) 2.	Uncharacterized protein.	0.803
ENSLCAP00010049166	rap1b	ENSLCAP00010049166	ENSLCAP00010017502	Rap guanine nucleotide exchange factor (GEF) 2.	Uncharacterized protein.	0.803
ENSLCAP00010051319	LOC108884107	ENSLCAP00010051319	ENSLCAP00010006905	N-terminal Ras-GEF domain-containing protein.	Uncharacterized protein.	0.966