(26 nodes) Stem cell proliferation network (Lates calcarifer)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	arih2	RBR-type E3 ubiquitin transferase. (511 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	ism1	AMOP domain-containing protein. (453 aa)
	Nf1	Neurofibromin 1b. (2806 aa)
	kdf1	Uncharacterized protein. (401 aa)
	Mettl3	Methyltransferase like 3; Belongs to the MT-A70-like family. (579 aa)
	LOC108876160	Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
	ENSLCAP00010016816	Centrosomal protein 120. (977 aa)
	ETV6	Uncharacterized protein. (490 aa)
	ercc2	Helicase ATP-binding domain-containing protein. (774 aa)
	ENSLCAP00010021412	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (174 aa)
	ENSLCAP00010021801	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (190 aa)
	Brca2	Breast cancer 2, early onset. (2872 aa)
	ENSLCAP00010030874	Uncharacterized protein. (69 aa)
	lig4	DNA ligase. (918 aa)
	ENSLCAP00010033319	MDS1 and EVI1 complex locus. (1219 aa)
	Znrf3	Zinc and ring finger 3. (884 aa)
	rnf43	RING-type domain-containing protein. (821 aa)
	bysl	Uncharacterized protein. (436 aa)
	LOC108877739	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (225 aa)
	ENSLCAP00010040426	YTH N(6)-methyladenosine RNA binding protein 2. (671 aa)
	Sfrp2	Secreted frizzled-related protein 2. (284 aa)
	LOC108886611	Uncharacterized protein. (389 aa)
	ENSLCAP00010051016	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (666 aa)
	trim71	Uncharacterized protein. (830 aa)
	Cdkn2c	ANK_REP_REGION domain-containing protein. (118 aa)

Your Current Organism:

Lates calcarifer

NCBI taxonomy Id: 8187
Other names: Asian seabass, Holocentrus calcarifer, L. calcarifer, barramundi, barramundi perch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Brca2	ENSLCAP00010051016	ENSLCAP00010030231	ENSLCAP00010051016	Breast cancer 2, early onset.	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.618
Brca2	Nf1	ENSLCAP00010030231	ENSLCAP00010005746	Breast cancer 2, early onset.	Neurofibromin 1b.	0.589
Brca2	ercc2	ENSLCAP00010030231	ENSLCAP00010019831	Breast cancer 2, early onset.	Helicase ATP-binding domain-containing protein.	0.659
Brca2	lig4	ENSLCAP00010030231	ENSLCAP00010031670	Breast cancer 2, early onset.	DNA ligase.	0.736
ENSLCAP00010040426	Mettl3	ENSLCAP00010040426	ENSLCAP00010013996	YTH N(6)-methyladenosine RNA binding protein 2.	Methyltransferase like 3; Belongs to the MT-A70-like family.	0.600
ENSLCAP00010051016	Brca2	ENSLCAP00010051016	ENSLCAP00010030231	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	Breast cancer 2, early onset.	0.618
ENSLCAP00010051016	ercc2	ENSLCAP00010051016	ENSLCAP00010019831	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	Helicase ATP-binding domain-containing protein.	0.596
ENSLCAP00010051016	lig4	ENSLCAP00010051016	ENSLCAP00010031670	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	DNA ligase.	0.984
LOC108876160	fgf2	ENSLCAP00010015620	ENSLCAP00010002620	Transforming growth factor beta; Belongs to the TGF-beta family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.607
Mettl3	ENSLCAP00010040426	ENSLCAP00010013996	ENSLCAP00010040426	Methyltransferase like 3; Belongs to the MT-A70-like family.	YTH N(6)-methyladenosine RNA binding protein 2.	0.600
Nf1	Brca2	ENSLCAP00010005746	ENSLCAP00010030231	Neurofibromin 1b.	Breast cancer 2, early onset.	0.589
Znrf3	rnf43	ENSLCAP00010033668	ENSLCAP00010038101	Zinc and ring finger 3.	RING-type domain-containing protein.	0.764
ercc2	Brca2	ENSLCAP00010019831	ENSLCAP00010030231	Helicase ATP-binding domain-containing protein.	Breast cancer 2, early onset.	0.659
ercc2	ENSLCAP00010051016	ENSLCAP00010019831	ENSLCAP00010051016	Helicase ATP-binding domain-containing protein.	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.596
ercc2	lig4	ENSLCAP00010019831	ENSLCAP00010031670	Helicase ATP-binding domain-containing protein.	DNA ligase.	0.624
fgf2	LOC108876160	ENSLCAP00010002620	ENSLCAP00010015620	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.607
lig4	Brca2	ENSLCAP00010031670	ENSLCAP00010030231	DNA ligase.	Breast cancer 2, early onset.	0.736
lig4	ENSLCAP00010051016	ENSLCAP00010031670	ENSLCAP00010051016	DNA ligase.	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.984
lig4	ercc2	ENSLCAP00010031670	ENSLCAP00010019831	DNA ligase.	Helicase ATP-binding domain-containing protein.	0.624
rnf43	Znrf3	ENSLCAP00010038101	ENSLCAP00010033668	RING-type domain-containing protein.	Zinc and ring finger 3.	0.764