(37 nodes) Positive regulation of peptide hormone secretion network (Lates calcarifer)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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co-expression

protein homology

Your Input:
	nr1h4	Uncharacterized protein. (485 aa)
	mcu	MCU domain-containing protein. (377 aa)
	ENSLCAP00010033852	Si:dkey-211g8.9. (295 aa)
	capn10	Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (671 aa)
	LOC108884137	RabBD domain-containing protein. (1367 aa)
	FFAR4	G_PROTEIN_RECEP_F1_2 domain-containing protein. (352 aa)
	LOC108881787	CRF domain-containing protein. (171 aa)
	pdx1	Homeobox domain-containing protein. (261 aa)
	LOC108892270	tRNA-binding domain-containing protein. (369 aa)
	ENSLCAP00010024560	MCU domain-containing protein. (249 aa)
	ucn	CRF domain-containing protein. (146 aa)
	LOC108895615	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1184 aa)
	trh	Pro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (270 aa)
	LOC108884681	Uncharacterized protein. (232 aa)
	tnfsf11	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (268 aa)
	fgb	Fibrinogen C-terminal domain-containing protein. (492 aa)
	LOC108879344	NR LBD domain-containing protein. (261 aa)
	nr0b2	NR LBD domain-containing protein. (258 aa)
	adcy8	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1240 aa)
	MCUB	MCU domain-containing protein. (336 aa)
	LOC108900264	NR LBD domain-containing protein. (261 aa)
	LOC108884930	CRF domain-containing protein. (140 aa)
	aimp1	tRNA-binding domain-containing protein. (323 aa)
	LOC108882618	Uncharacterized protein. (512 aa)
	c2cd2l	SMP_C2CD2L domain-containing protein. (700 aa)
	LOC108900585	Uncharacterized protein. (235 aa)
	psmd9	PDZ domain-containing protein. (212 aa)
	pla2g6	Uncharacterized protein. (825 aa)
	tm7sf3	DUF4203 domain-containing protein. (565 aa)
	ENSLCAP00010054314	Si:ch211-132f19.7; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (844 aa)
	mpc2	Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (126 aa)
	LOC108893121	tRNA-binding domain-containing protein. (315 aa)
	Rfx6	Regulatory factor X, 6. (967 aa)
	bad	Uncharacterized protein. (229 aa)
	LOC108881433	Motilin_assoc domain-containing protein. (107 aa)
	aacs	Uncharacterized protein. (678 aa)
	sirt6	Deacetylase sirtuin-type domain-containing protein. (351 aa)

Your Current Organism:

Lates calcarifer

NCBI taxonomy Id: 8187
Other names: Asian seabass, Holocentrus calcarifer, L. calcarifer, barramundi, barramundi perch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSLCAP00010033852	FFAR4	ENSLCAP00010033852	ENSLCAP00010031551	Si:dkey-211g8.9.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.644
FFAR4	ENSLCAP00010033852	ENSLCAP00010031551	ENSLCAP00010033852	G_PROTEIN_RECEP_F1_2 domain-containing protein.	Si:dkey-211g8.9.	0.644
LOC108879344	LOC108882618	ENSLCAP00010013665	ENSLCAP00010004014	NR LBD domain-containing protein.	Uncharacterized protein.	0.494
LOC108879344	nr1h4	ENSLCAP00010013665	ENSLCAP00010034558	NR LBD domain-containing protein.	Uncharacterized protein.	0.494
LOC108881433	LOC108881787	ENSLCAP00010038847	ENSLCAP00010027771	Motilin_assoc domain-containing protein.	CRF domain-containing protein.	0.507
LOC108881433	LOC108884930	ENSLCAP00010038847	ENSLCAP00010010458	Motilin_assoc domain-containing protein.	CRF domain-containing protein.	0.507
LOC108881433	trh	ENSLCAP00010038847	ENSLCAP00010020811	Motilin_assoc domain-containing protein.	Pro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.	0.709
LOC108881433	ucn	ENSLCAP00010038847	ENSLCAP00010023614	Motilin_assoc domain-containing protein.	CRF domain-containing protein.	0.451
LOC108881787	LOC108881433	ENSLCAP00010027771	ENSLCAP00010038847	CRF domain-containing protein.	Motilin_assoc domain-containing protein.	0.507
LOC108881787	LOC108884930	ENSLCAP00010027771	ENSLCAP00010010458	CRF domain-containing protein.	CRF domain-containing protein.	0.904
LOC108881787	trh	ENSLCAP00010027771	ENSLCAP00010020811	CRF domain-containing protein.	Pro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.	0.473
LOC108881787	ucn	ENSLCAP00010027771	ENSLCAP00010023614	CRF domain-containing protein.	CRF domain-containing protein.	0.922
LOC108882618	LOC108879344	ENSLCAP00010004014	ENSLCAP00010013665	Uncharacterized protein.	NR LBD domain-containing protein.	0.494
LOC108882618	LOC108900264	ENSLCAP00010004014	ENSLCAP00010010628	Uncharacterized protein.	NR LBD domain-containing protein.	0.494
LOC108882618	nr0b2	ENSLCAP00010004014	ENSLCAP00010012504	Uncharacterized protein.	NR LBD domain-containing protein.	0.494
LOC108884930	LOC108881433	ENSLCAP00010010458	ENSLCAP00010038847	CRF domain-containing protein.	Motilin_assoc domain-containing protein.	0.507
LOC108884930	LOC108881787	ENSLCAP00010010458	ENSLCAP00010027771	CRF domain-containing protein.	CRF domain-containing protein.	0.904
LOC108884930	trh	ENSLCAP00010010458	ENSLCAP00010020811	CRF domain-containing protein.	Pro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.	0.473
LOC108884930	ucn	ENSLCAP00010010458	ENSLCAP00010023614	CRF domain-containing protein.	CRF domain-containing protein.	0.912
LOC108900264	LOC108882618	ENSLCAP00010010628	ENSLCAP00010004014	NR LBD domain-containing protein.	Uncharacterized protein.	0.494