(48 nodes) Extrinsic apoptotic signaling pathway network (Lates calcarifer)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	dedd2	DED domain-containing protein. (412 aa)
	ENSLCAP00010059112	Caspase 8, apoptosis-related cysteine peptidase, like 2; Belongs to the peptidase C14A family. (647 aa)
	ENSLCAP00010058824	Hematopoietic death receptor. (406 aa)
	gsk3b	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (425 aa)
	LOC108877071	Uncharacterized protein. (191 aa)
	rnf41	Uncharacterized protein. (318 aa)
	LOC108881923	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (438 aa)
	LOC108881908	Daxx domain-containing protein. (723 aa)
	LOC108872574	Transforming growth factor beta; Belongs to the TGF-beta family. (420 aa)
	bcl2l11	Bclx_interact domain-containing protein. (284 aa)
	LOC108885588	BH4_2 domain-containing protein. (221 aa)
	bad	Uncharacterized protein. (229 aa)
	skil	c-SKI_SMAD_bind domain-containing protein. (772 aa)
	LOC108889267	Sortilin. (826 aa)
	ENSLCAP00010030143	P53-induced death domain protein 1. (910 aa)
	LOC108883475	BH4_2 domain-containing protein. (213 aa)
	Ddx47	DEAD (Asp-Glu-Ala-Asp) box polypeptide 47; Belongs to the DEAD box helicase family. (486 aa)
	ENSLCAP00010025630	Sortilin. (753 aa)
	Casp8ap2	Uncharacterized protein. (1358 aa)
	LOC108890976	Uncharacterized protein. (115 aa)
	bok	Uncharacterized protein. (216 aa)
	casp2	Uncharacterized protein; Belongs to the peptidase C14A family. (468 aa)
	ENSLCAP00010019751	Death-domain associated protein. (411 aa)
	LOC108880505	Uncharacterized protein. (195 aa)
	LOC108880508	Uncharacterized protein. (205 aa)
	LOC108879004	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (267 aa)
	bag3	Uncharacterized protein. (572 aa)
	LOC108876160	Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
	Itprip	Inositol 1,4,5-trisphosphate receptor interacting protein. (382 aa)
	fas	Uncharacterized protein. (324 aa)
	LOC108881637	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (581 aa)
	LOC108902465	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (246 aa)
	bax	Uncharacterized protein. (192 aa)
	ENSLCAP00010012586	Tumor necrosis factor receptor superfamily, member a. (419 aa)
	rb1cc1	ATG11 domain-containing protein. (1651 aa)
	ENSLCAP00010009593	MCL1, BCL2 family apoptosis regulator b. (325 aa)
	ENSLCAP00010008403	Uncharacterized protein; Belongs to the peptidase C14A family. (480 aa)
	Catip	Uncharacterized protein; Belongs to the peptidase C14A family. (459 aa)
	ENSLCAP00010007633	Si:dkeyp-80c12.4. (542 aa)
	tgfb2	Transforming growth factor beta; Belongs to the TGF-beta family. (444 aa)
	Nf1	Neurofibromin 1b. (2806 aa)
	ENSLCAP00010005441	Uncharacterized protein. (478 aa)
	tradd	Death domain-containing protein. (293 aa)
	LOC108899401	TNF_2 domain-containing protein. (254 aa)
	G0S2	Uncharacterized protein. (125 aa)
	LOC108884881	BH4_2 domain-containing protein. (232 aa)
	Parp2	Poly [ADP-ribose] polymerase. (658 aa)
	LOC108880704	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (440 aa)

Your Current Organism:

Lates calcarifer

NCBI taxonomy Id: 8187
Other names: Asian seabass, Holocentrus calcarifer, L. calcarifer, barramundi, barramundi perch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Casp8ap2	Catip	ENSLCAP00010023849	ENSLCAP00010008252	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.443
Casp8ap2	ENSLCAP00010008403	ENSLCAP00010023849	ENSLCAP00010008403	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.514
Casp8ap2	ENSLCAP00010059112	ENSLCAP00010023849	ENSLCAP00010059112	Uncharacterized protein.	Caspase 8, apoptosis-related cysteine peptidase, like 2; Belongs to the peptidase C14A family.	0.514
Catip	Casp8ap2	ENSLCAP00010008252	ENSLCAP00010023849	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.443
Catip	ENSLCAP00010009593	ENSLCAP00010008252	ENSLCAP00010009593	Uncharacterized protein; Belongs to the peptidase C14A family.	MCL1, BCL2 family apoptosis regulator b.	0.437
Catip	ENSLCAP00010012586	ENSLCAP00010008252	ENSLCAP00010012586	Uncharacterized protein; Belongs to the peptidase C14A family.	Tumor necrosis factor receptor superfamily, member a.	0.829
Catip	ENSLCAP00010058824	ENSLCAP00010008252	ENSLCAP00010058824	Uncharacterized protein; Belongs to the peptidase C14A family.	Hematopoietic death receptor.	0.546
Catip	LOC108879004	ENSLCAP00010008252	ENSLCAP00010017663	Uncharacterized protein; Belongs to the peptidase C14A family.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.835
Catip	LOC108880505	ENSLCAP00010008252	ENSLCAP00010018598	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.953
Catip	LOC108884881	ENSLCAP00010008252	ENSLCAP00010001507	Uncharacterized protein; Belongs to the peptidase C14A family.	BH4_2 domain-containing protein.	0.401
Catip	LOC108885588	ENSLCAP00010008252	ENSLCAP00010041376	Uncharacterized protein; Belongs to the peptidase C14A family.	BH4_2 domain-containing protein.	0.401
Catip	casp2	ENSLCAP00010008252	ENSLCAP00010021664	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.482
Catip	fas	ENSLCAP00010008252	ENSLCAP00010015051	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.877
Catip	tradd	ENSLCAP00010008252	ENSLCAP00010004372	Uncharacterized protein; Belongs to the peptidase C14A family.	Death domain-containing protein.	0.836
ENSLCAP00010008403	Casp8ap2	ENSLCAP00010008403	ENSLCAP00010023849	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.514
ENSLCAP00010008403	ENSLCAP00010009593	ENSLCAP00010008403	ENSLCAP00010009593	Uncharacterized protein; Belongs to the peptidase C14A family.	MCL1, BCL2 family apoptosis regulator b.	0.466
ENSLCAP00010008403	ENSLCAP00010012586	ENSLCAP00010008403	ENSLCAP00010012586	Uncharacterized protein; Belongs to the peptidase C14A family.	Tumor necrosis factor receptor superfamily, member a.	0.880
ENSLCAP00010008403	ENSLCAP00010058824	ENSLCAP00010008403	ENSLCAP00010058824	Uncharacterized protein; Belongs to the peptidase C14A family.	Hematopoietic death receptor.	0.597
ENSLCAP00010008403	LOC108879004	ENSLCAP00010008403	ENSLCAP00010017663	Uncharacterized protein; Belongs to the peptidase C14A family.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.895
ENSLCAP00010008403	LOC108880505	ENSLCAP00010008403	ENSLCAP00010018598	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.972