(20 nodes) Programmed necrotic cell death network (Lates calcarifer)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	alkbh7	Uncharacterized protein. (230 aa)
	Cyld	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family. (920 aa)
	ENSLCAP00010032551	Inositol-tetrakisphosphate 1-kinase; Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Belongs to the ITPK1 family. (310 aa)
	ENSLCAP00010024823	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (365 aa)
	ENSLCAP00010023502	Ins134_P3_kin domain-containing protein. (259 aa)
	LOC108880505	Uncharacterized protein. (195 aa)
	LOC108879004	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (267 aa)
	fas	Uncharacterized protein. (324 aa)
	bax	Uncharacterized protein. (192 aa)
	ENSLCAP00010013688	Inositol-tetrakisphosphate 1-kinase; Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Belongs to the ITPK1 family. (304 aa)
	LOC108890753	Protein kinase domain-containing protein. (531 aa)
	LOC108899401	TNF_2 domain-containing protein. (254 aa)
	LOC108884442	IRF tryptophan pentad repeat domain-containing protein. (466 aa)
	Itpk1	Inositol-tetrakisphosphate 1-kinase b. (401 aa)
	ENSLCAP00010046779	Cylindromatosis (turban tumor syndrome), like; Belongs to the peptidase C19 family. (520 aa)
	ENSLCAP00010043697	Inositol-tetrakisphosphate 1-kinase; Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Belongs to the ITPK1 family. (335 aa)
	LOC108885597	Uncharacterized protein. (712 aa)
	ENSLCAP00010037600	Kinase; Belongs to the inositol phosphokinase (IPK) family. (446 aa)
	ENSLCAP00010036864	Protein kinase domain-containing protein. (318 aa)
	MLKL	Protein kinase domain-containing protein. (474 aa)

Your Current Organism:

Lates calcarifer

NCBI taxonomy Id: 8187
Other names: Asian seabass, Holocentrus calcarifer, L. calcarifer, barramundi, barramundi perch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cyld	ENSLCAP00010024823	ENSLCAP00010034631	ENSLCAP00010024823	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.445
Cyld	LOC108880505	ENSLCAP00010034631	ENSLCAP00010018598	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family.	Uncharacterized protein.	0.650
Cyld	LOC108890753	ENSLCAP00010034631	ENSLCAP00010009740	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family.	Protein kinase domain-containing protein.	0.445
ENSLCAP00010024823	Cyld	ENSLCAP00010024823	ENSLCAP00010034631	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family.	0.445
ENSLCAP00010024823	ENSLCAP00010036864	ENSLCAP00010024823	ENSLCAP00010036864	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein.	0.888
ENSLCAP00010024823	ENSLCAP00010046779	ENSLCAP00010024823	ENSLCAP00010046779	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Cylindromatosis (turban tumor syndrome), like; Belongs to the peptidase C19 family.	0.445
ENSLCAP00010024823	LOC108879004	ENSLCAP00010024823	ENSLCAP00010017663	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.473
ENSLCAP00010024823	LOC108880505	ENSLCAP00010024823	ENSLCAP00010018598	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.956
ENSLCAP00010024823	LOC108885597	ENSLCAP00010024823	ENSLCAP00010042082	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.445
ENSLCAP00010024823	LOC108890753	ENSLCAP00010024823	ENSLCAP00010009740	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein.	0.904
ENSLCAP00010024823	MLKL	ENSLCAP00010024823	ENSLCAP00010036863	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein.	0.988
ENSLCAP00010024823	fas	ENSLCAP00010024823	ENSLCAP00010015051	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.514
ENSLCAP00010036864	ENSLCAP00010024823	ENSLCAP00010036864	ENSLCAP00010024823	Protein kinase domain-containing protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.888
ENSLCAP00010036864	LOC108880505	ENSLCAP00010036864	ENSLCAP00010018598	Protein kinase domain-containing protein.	Uncharacterized protein.	0.589
ENSLCAP00010036864	LOC108890753	ENSLCAP00010036864	ENSLCAP00010009740	Protein kinase domain-containing protein.	Protein kinase domain-containing protein.	0.888
ENSLCAP00010043697	Itpk1	ENSLCAP00010043697	ENSLCAP00010048065	Inositol-tetrakisphosphate 1-kinase; Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Belongs to the ITPK1 family.	Inositol-tetrakisphosphate 1-kinase b.	0.903
ENSLCAP00010046779	ENSLCAP00010024823	ENSLCAP00010046779	ENSLCAP00010024823	Cylindromatosis (turban tumor syndrome), like; Belongs to the peptidase C19 family.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.445
ENSLCAP00010046779	LOC108880505	ENSLCAP00010046779	ENSLCAP00010018598	Cylindromatosis (turban tumor syndrome), like; Belongs to the peptidase C19 family.	Uncharacterized protein.	0.650
ENSLCAP00010046779	LOC108890753	ENSLCAP00010046779	ENSLCAP00010009740	Cylindromatosis (turban tumor syndrome), like; Belongs to the peptidase C19 family.	Protein kinase domain-containing protein.	0.445
Itpk1	ENSLCAP00010043697	ENSLCAP00010048065	ENSLCAP00010043697	Inositol-tetrakisphosphate 1-kinase b.	Inositol-tetrakisphosphate 1-kinase; Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Belongs to the ITPK1 family.	0.903