STRINGSTRING
LOC108876221 LOC108876221 cdc45 cdc45 rpa3 rpa3 ENSLCAP00010002675 ENSLCAP00010002675 LOC108875967 LOC108875967 dbf4 dbf4 ENSLCAP00010005350 ENSLCAP00010005350 ENSLCAP00010006345 ENSLCAP00010006345 ENSLCAP00010006675 ENSLCAP00010006675 Orc5 Orc5 rad9b rad9b LOC108882499 LOC108882499 ENSLCAP00010055815 ENSLCAP00010055815 rfc4 rfc4 ENSLCAP00010055640 ENSLCAP00010055640 RPA1 RPA1 rfc3 rfc3 cdc7 cdc7 mcm7 mcm7 mcm10 mcm10 Orc3 Orc3 mcm5 mcm5 cdk2-2 cdk2-2 LOC108892908 LOC108892908 atrip atrip Rfc5 Rfc5 ENSLCAP00010032855 ENSLCAP00010032855 ENSLCAP00010029188 ENSLCAP00010029188 Orc4 Orc4 Cdc25b Cdc25b rpa2 rpa2 mcm2 mcm2 rad9a rad9a Rfc2 Rfc2 chek1 chek1 RCBTB1 RCBTB1 LOC108883334 LOC108883334 hus1 hus1 cdk2 cdk2 mcm3 mcm3 mcm4 mcm4 Rad1 Rad1 ENSLCAP00010008769 ENSLCAP00010008769 mcm6 mcm6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC108876221BTB domain-containing protein. (546 aa)
cdc45Uncharacterized protein. (568 aa)
rpa3Uncharacterized protein. (122 aa)
ENSLCAP00010002675Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (556 aa)
LOC108875967Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (606 aa)
dbf4Uncharacterized protein. (628 aa)
ENSLCAP00010005350Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (806 aa)
ENSLCAP00010006345Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (869 aa)
ENSLCAP00010006675Uncharacterized protein. (176 aa)
Orc5Origin recognition complex, subunit 5. (449 aa)
rad9bUncharacterized protein. (328 aa)
LOC108882499Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (573 aa)
ENSLCAP00010055815Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (285 aa)
rfc4AAA domain-containing protein. (357 aa)
ENSLCAP00010055640annotation not available (277 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (678 aa)
rfc3AAA domain-containing protein. (356 aa)
cdc7Protein kinase domain-containing protein. (610 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (729 aa)
mcm10Mcm10 domain-containing protein. (908 aa)
Orc3Origin recognition complex, subunit 3. (712 aa)
mcm5DNA helicase; Belongs to the MCM family. (737 aa)
cdk2-2Cyclin-dependent kinase 2. (298 aa)
LOC108892908BTB domain-containing protein. (570 aa)
atripUncharacterized protein. (873 aa)
Rfc5AAA domain-containing protein. (350 aa)
ENSLCAP00010032855RAD17 checkpoint clamp loader component. (467 aa)
ENSLCAP00010029188ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2552 aa)
Orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (462 aa)
Cdc25bRhodanese domain-containing protein. (385 aa)
rpa2RPA_C domain-containing protein. (290 aa)
mcm2DNA helicase; Belongs to the MCM family. (916 aa)
rad9aCell cycle checkpoint control protein; Belongs to the rad9 family. (393 aa)
Rfc2Replication factor C (activator 1) 2. (444 aa)
chek1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (486 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (508 aa)
LOC108883334Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (940 aa)
hus1Checkpoint protein; Belongs to the HUS1 family. (285 aa)
cdk2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (298 aa)
mcm3DNA helicase; Belongs to the MCM family. (815 aa)
mcm4DNA helicase; Belongs to the MCM family. (860 aa)
Rad1RAD1 homolog (S. pombe). (329 aa)
ENSLCAP00010008769Origin recognition complex, subunit 2. (534 aa)
mcm6DNA helicase; Belongs to the MCM family. (832 aa)
Your Current Organism:
Lates calcarifer
NCBI taxonomy Id: 8187
Other names: Asian seabass, Holocentrus calcarifer, L. calcarifer, barramundi, barramundi perch
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