STRINGSTRING
rfc4 rfc4 ENSLCAP00010000450 ENSLCAP00010000450 Pold1 Pold1 Pot1 Pot1 Rfc1 Rfc1 LOC108875967 LOC108875967 lig1 lig1 ENSLCAP00010006675 ENSLCAP00010006675 pold3 pold3 pcna pcna pola2 pola2 LOC108876221 LOC108876221 ENSLCAP00010008183 ENSLCAP00010008183 dscc1 dscc1 nop10 nop10 ENSLCAP00010055689 ENSLCAP00010055689 ENSLCAP00010055815 ENSLCAP00010055815 chtf18 chtf18 Dna2 Dna2 ccna2 ccna2 PPP6C-2 PPP6C-2 Prim2 Prim2 meiob meiob nhp2 nhp2 blm blm ENSLCAP00010011831 ENSLCAP00010011831 rpa3 rpa3 cdk2 cdk2 stn1 stn1 RCBTB1 RCBTB1 fen1 fen1 Rfc2 Rfc2 exd2 exd2 rpa2 rpa2 ankrd28 ankrd28 PPP6C PPP6C LOC108900468 LOC108900468 Rfc5 Rfc5 wrap53 wrap53 Ruvbl2 Ruvbl2 LOC108892908 LOC108892908 prim1 prim1 LOC108877712 LOC108877712 ten1 ten1 cdk2-2 cdk2-2 ENSLCAP00010044467 ENSLCAP00010044467 ENSLCAP00010044578 ENSLCAP00010044578 chtf8 chtf8 ENSLCAP00010046546 ENSLCAP00010046546 Gar1 Gar1 ccna1 ccna1 dkc1 dkc1 pif1 pif1 rfc3 rfc3 LOC108902035 LOC108902035 ENSLCAP00010050488 ENSLCAP00010050488 trub1 trub1 RPA1 RPA1 tert tert LOC108886744 LOC108886744 pold2 pold2 Terf2 Terf2 ENSLCAP00010055044 ENSLCAP00010055044 pold4 pold4 ENSLCAP00010055640 ENSLCAP00010055640
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rfc4AAA domain-containing protein. (357 aa)
ENSLCAP00010000450TINF2_N domain-containing protein. (96 aa)
Pold1DNA polymerase. (1098 aa)
Pot1Protection of telomeres 1 homolog. (536 aa)
Rfc1Replication factor C subunit 1. (1148 aa)
LOC108875967Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (606 aa)
lig1DNA ligase. (1015 aa)
ENSLCAP00010006675Uncharacterized protein. (176 aa)
pold3Uncharacterized protein. (446 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (602 aa)
LOC108876221BTB domain-containing protein. (546 aa)
ENSLCAP00010008183RecQ helicase-like 4. (1236 aa)
dscc1Uncharacterized protein. (390 aa)
nop10Uncharacterized protein. (64 aa)
ENSLCAP00010055689SHQ1, H/ACA ribonucleoprotein assembly factor. (577 aa)
ENSLCAP00010055815Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (285 aa)
chtf18AAA domain-containing protein. (921 aa)
Dna2DNA replication helicase/nuclease 2. (1408 aa)
ccna2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (436 aa)
PPP6C-2Serine/threonine-protein phosphatase. (305 aa)
Prim2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (502 aa)
meiobUncharacterized protein. (460 aa)
nhp2Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (159 aa)
blmUncharacterized protein. (1413 aa)
ENSLCAP00010011831DNA polymerase. (1466 aa)
rpa3Uncharacterized protein. (122 aa)
cdk2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (298 aa)
stn1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (382 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (508 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
Rfc2Replication factor C (activator 1) 2. (444 aa)
exd23'-5' exonuclease domain-containing protein. (639 aa)
rpa2RPA_C domain-containing protein. (290 aa)
ankrd28ANK_REP_REGION domain-containing protein. (1083 aa)
PPP6CSerine/threonine-protein phosphatase. (301 aa)
LOC108900468Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1108 aa)
Rfc5AAA domain-containing protein. (350 aa)
wrap53WD_REPEATS_REGION domain-containing protein. (557 aa)
Ruvbl2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (418 aa)
LOC108892908BTB domain-containing protein. (570 aa)
prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (424 aa)
LOC108877712ANK_REP_REGION domain-containing protein. (1101 aa)
ten1Uncharacterized protein. (124 aa)
cdk2-2Cyclin-dependent kinase 2. (298 aa)
ENSLCAP00010044467BRCT domain-containing protein. (486 aa)
ENSLCAP00010044578Uncharacterized protein. (476 aa)
chtf8Uncharacterized protein. (198 aa)
ENSLCAP00010046546Ankyrin repeat domain 44. (1050 aa)
Gar1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (222 aa)
ccna1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (416 aa)
dkc1PUA domain-containing protein. (507 aa)
pif1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (632 aa)
rfc3AAA domain-containing protein. (356 aa)
LOC108902035ANK_REP_REGION domain-containing protein. (168 aa)
ENSLCAP00010050488Zgc:110269. (339 aa)
trub1Uncharacterized protein. (278 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (678 aa)
tertTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1100 aa)
LOC108886744ANK_REP_REGION domain-containing protein. (168 aa)
pold2Uncharacterized protein. (471 aa)
Terf2Uncharacterized protein. (185 aa)
ENSLCAP00010055044HTH myb-type domain-containing protein. (124 aa)
pold4Uncharacterized protein. (108 aa)
ENSLCAP00010055640annotation not available (277 aa)
Your Current Organism:
Lates calcarifer
NCBI taxonomy Id: 8187
Other names: Asian seabass, Holocentrus calcarifer, L. calcarifer, barramundi, barramundi perch
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.