(27 nodes) Translesion synthesis by POLK network (Lates calcarifer)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Ubb	Ubiquitin B. (517 aa)
	mad2l2	HORMA domain-containing protein. (210 aa)
	Rfc1	Replication factor C subunit 1. (1148 aa)
	LOC108875967	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (606 aa)
	ENSLCAP00010004003	REV3-like, polymerase (DNA directed), zeta, catalytic subunit. (2860 aa)
	rps27a	Ubiquitin-like domain-containing protein. (156 aa)
	ENSLCAP00010006675	Uncharacterized protein. (176 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	LOC108876221	BTB domain-containing protein. (546 aa)
	rpa3	Uncharacterized protein. (122 aa)
	Rev1	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1013 aa)
	RCBTB1	RCC1 and BTB domain containing protein 1. (508 aa)
	Rfc2	Replication factor C (activator 1) 2. (444 aa)
	rpa2	RPA_C domain-containing protein. (290 aa)
	ENSLCAP00010029854	ATPase family, AAA domain containing 5a. (1490 aa)
	LOC108876789	Ubiquitin-like domain-containing protein. (128 aa)
	kxd1	KxDL domain-containing protein. (184 aa)
	Rfc5	AAA domain-containing protein. (350 aa)
	LOC108892908	BTB domain-containing protein. (570 aa)
	LOC108883656	Ubiquitin-like domain-containing protein. (128 aa)
	ENSLCAP00010046672	Ubiquitin-like domain-containing protein. (116 aa)
	LOC108876789-2	Ubiquitin-like domain-containing protein. (155 aa)
	rfc3	AAA domain-containing protein. (356 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (678 aa)
	rfc4	AAA domain-containing protein. (357 aa)
	polk	UmuC domain-containing protein. (887 aa)
	meiob	Uncharacterized protein. (460 aa)

Your Current Organism:

Lates calcarifer

NCBI taxonomy Id: 8187
Other names: Asian seabass, Holocentrus calcarifer, L. calcarifer, barramundi, barramundi perch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSLCAP00010004003	ENSLCAP00010006675	ENSLCAP00010004003	ENSLCAP00010006675	REV3-like, polymerase (DNA directed), zeta, catalytic subunit.	Uncharacterized protein.	0.682
ENSLCAP00010004003	ENSLCAP00010029854	ENSLCAP00010004003	ENSLCAP00010029854	REV3-like, polymerase (DNA directed), zeta, catalytic subunit.	ATPase family, AAA domain containing 5a.	0.810
ENSLCAP00010004003	LOC108875967	ENSLCAP00010004003	ENSLCAP00010003251	REV3-like, polymerase (DNA directed), zeta, catalytic subunit.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.740
ENSLCAP00010004003	LOC108876789	ENSLCAP00010004003	ENSLCAP00010031146	REV3-like, polymerase (DNA directed), zeta, catalytic subunit.	Ubiquitin-like domain-containing protein.	0.575
ENSLCAP00010004003	LOC108876789-2	ENSLCAP00010004003	ENSLCAP00010046809	REV3-like, polymerase (DNA directed), zeta, catalytic subunit.	Ubiquitin-like domain-containing protein.	0.575
ENSLCAP00010004003	LOC108883656	ENSLCAP00010004003	ENSLCAP00010046378	REV3-like, polymerase (DNA directed), zeta, catalytic subunit.	Ubiquitin-like domain-containing protein.	0.575
ENSLCAP00010004003	RPA1	ENSLCAP00010004003	ENSLCAP00010051821	REV3-like, polymerase (DNA directed), zeta, catalytic subunit.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.740
ENSLCAP00010004003	Rev1	ENSLCAP00010004003	ENSLCAP00010014861	REV3-like, polymerase (DNA directed), zeta, catalytic subunit.	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family.	0.994
ENSLCAP00010004003	Rfc1	ENSLCAP00010004003	ENSLCAP00010002331	REV3-like, polymerase (DNA directed), zeta, catalytic subunit.	Replication factor C subunit 1.	0.801
ENSLCAP00010004003	Rfc2	ENSLCAP00010004003	ENSLCAP00010021203	REV3-like, polymerase (DNA directed), zeta, catalytic subunit.	Replication factor C (activator 1) 2.	0.810
ENSLCAP00010004003	Rfc5	ENSLCAP00010004003	ENSLCAP00010034522	REV3-like, polymerase (DNA directed), zeta, catalytic subunit.	AAA domain-containing protein.	0.810
ENSLCAP00010004003	mad2l2	ENSLCAP00010004003	ENSLCAP00010001134	REV3-like, polymerase (DNA directed), zeta, catalytic subunit.	HORMA domain-containing protein.	0.999
ENSLCAP00010004003	meiob	ENSLCAP00010004003	ENSLCAP00010060389	REV3-like, polymerase (DNA directed), zeta, catalytic subunit.	Uncharacterized protein.	0.711
ENSLCAP00010004003	pcna	ENSLCAP00010004003	ENSLCAP00010007860	REV3-like, polymerase (DNA directed), zeta, catalytic subunit.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.980
ENSLCAP00010004003	polk	ENSLCAP00010004003	ENSLCAP00010060302	REV3-like, polymerase (DNA directed), zeta, catalytic subunit.	UmuC domain-containing protein.	0.942
ENSLCAP00010004003	rfc3	ENSLCAP00010004003	ENSLCAP00010049213	REV3-like, polymerase (DNA directed), zeta, catalytic subunit.	AAA domain-containing protein.	0.810
ENSLCAP00010004003	rfc4	ENSLCAP00010004003	ENSLCAP00010055666	REV3-like, polymerase (DNA directed), zeta, catalytic subunit.	AAA domain-containing protein.	0.810
ENSLCAP00010004003	rpa2	ENSLCAP00010004003	ENSLCAP00010024284	REV3-like, polymerase (DNA directed), zeta, catalytic subunit.	RPA_C domain-containing protein.	0.682
ENSLCAP00010004003	rpa3	ENSLCAP00010004003	ENSLCAP00010012048	REV3-like, polymerase (DNA directed), zeta, catalytic subunit.	Uncharacterized protein.	0.729
ENSLCAP00010006675	ENSLCAP00010004003	ENSLCAP00010006675	ENSLCAP00010004003	Uncharacterized protein.	REV3-like, polymerase (DNA directed), zeta, catalytic subunit.	0.682