(126 nodes) Termination of translesion DNA synthesis network (Lates calcarifer)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (678 aa)
	pole	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2296 aa)
	meiob	Uncharacterized protein. (460 aa)
	polk	UmuC domain-containing protein. (887 aa)
	ENSLCAP00010059307	Ig-like domain-containing protein. (171 aa)
	LOC108884412	Uncharacterized protein. (551 aa)
	LOC108881387	SCY domain-containing protein. (125 aa)
	pole4	CBFD_NFYB_HMF domain-containing protein. (129 aa)
	rfc4	AAA domain-containing protein. (357 aa)
	pold4	Uncharacterized protein. (108 aa)
	ENSLCAP00010054724	annotation not available (207 aa)
	LOC108891078	Uncharacterized protein. (555 aa)
	pold2	Uncharacterized protein. (471 aa)
	ENSLCAP00010053910	Uncharacterized protein. (568 aa)
	ENSLCAP00010053252	Ubiquitin specific peptidase 43a; Belongs to the peptidase C19 family. (1058 aa)
	ENSLCAP00010050374	Uncharacterized protein. (606 aa)
	ENSLCAP00010000246	Ig-like domain-containing protein. (177 aa)
	Pold1	DNA polymerase. (1098 aa)
	LOC108886791	USP domain-containing protein; Belongs to the peptidase C19 family. (1323 aa)
	LOC108883298	Uncharacterized protein. (567 aa)
	LOC108883300	Uncharacterized protein. (451 aa)
	LOC108884762	Uncharacterized protein. (566 aa)
	LOC108884772	Uncharacterized protein. (558 aa)
	LOC108884771	Uncharacterized protein. (558 aa)
	LOC108884779	Uncharacterized protein. (559 aa)
	Rfc1	Replication factor C subunit 1. (1148 aa)
	LOC108880987	Uncharacterized protein. (429 aa)
	ENSLCAP00010002992	Uncharacterized protein. (263 aa)
	ENSLCAP00010003055	Uncharacterized protein. (332 aa)
	ENSLCAP00010003079	Uncharacterized protein. (475 aa)
	ENSLCAP00010003085	C2-set_2 domain-containing protein. (158 aa)
	LOC108875967	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (606 aa)
	ENSLCAP00010003975	B30.2/SPRY domain-containing protein. (186 aa)
	ENSLCAP00010003981	RING-type domain-containing protein. (148 aa)
	ENSLCAP00010003984	B30.2/SPRY domain-containing protein. (340 aa)
	LOC108874157	Uncharacterized protein. (536 aa)
	ENSLCAP00010004017	Si:dkey-46i9.6. (183 aa)
	ENSLCAP00010004023	Bloodthirsty-related gene family, member 12. (559 aa)
	ENSLCAP00010004179	Uncharacterized protein. (511 aa)
	ENSLCAP00010005412	Uncharacterized protein. (421 aa)
	ENSLCAP00010005416	Uncharacterized protein. (431 aa)
	rps27a	Ubiquitin-like domain-containing protein. (156 aa)
	ENSLCAP00010005801	Ubiquitin specific peptidase 31; Belongs to the peptidase C19 family. (1229 aa)
	LOC108880937	Uncharacterized protein. (556 aa)
	LOC108880936	Uncharacterized protein. (559 aa)
	ENSLCAP00010006675	Uncharacterized protein. (176 aa)
	pold3	Uncharacterized protein. (446 aa)
	LOC108880941	Uncharacterized protein. (558 aa)
	ENSLCAP00010007616	Ig-like domain-containing protein. (236 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	ENSLCAP00010007901	Uncharacterized protein. (440 aa)
	LOC108876221	BTB domain-containing protein. (546 aa)
	ENSLCAP00010008116	Uncharacterized protein. (400 aa)
	ENSLCAP00010008985	Uncharacterized protein. (530 aa)
	LOC108902425	Uncharacterized protein. (473 aa)
	ENSLCAP00010009099	B box-type domain-containing protein. (410 aa)
	pole3	CBFD_NFYB_HMF domain-containing protein. (149 aa)
	LOC108877214	Uncharacterized protein. (546 aa)
	ENSLCAP00010009712	Uncharacterized protein. (229 aa)
	LOC108891957	Uncharacterized protein. (608 aa)
	rpa3	Uncharacterized protein. (122 aa)
	LOC108873960	Uncharacterized protein. (547 aa)
	LOC108873958	Uncharacterized protein. (550 aa)
	ENSLCAP00010013775	B30.2/SPRY domain-containing protein. (362 aa)
	ENSLCAP00010049736	Uncharacterized protein. (476 aa)
	Rev1	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1013 aa)
	ENSLCAP00010015630	Uncharacterized protein. (406 aa)
	ENSLCAP00010015900	Ig-like domain-containing protein. (186 aa)
	RCBTB1	RCC1 and BTB domain containing protein 1. (508 aa)
	Rfc2	Replication factor C (activator 1) 2. (444 aa)
	LOC108886862	Ig-like domain-containing protein. (235 aa)
	polh	UmuC domain-containing protein. (738 aa)
	rpa2	RPA_C domain-containing protein. (290 aa)
	ENSLCAP00010024631	Ig-like domain-containing protein. (198 aa)
	LOC108888736	Uncharacterized protein. (547 aa)
	ENSLCAP00010024793	Uncharacterized protein. (452 aa)
	ENSLCAP00010026619	Uncharacterized protein. (624 aa)
	LOC108893345	Uncharacterized protein. (559 aa)
	LOC108885824	Butyrophilin subfamily 2 member A2-like. (473 aa)
	ENSLCAP00010027562	Uncharacterized protein. (546 aa)
	ENSLCAP00010029361	Ig-like domain-containing protein. (171 aa)
	ENSLCAP00010029365	Ig-like domain-containing protein. (146 aa)
	ENSLCAP00010029373	Ig-like domain-containing protein. (254 aa)
	ENSLCAP00010029403	Uncharacterized protein. (349 aa)
	ENSLCAP00010029662	RING-type domain-containing protein. (80 aa)
	ENSLCAP00010029670	Uncharacterized protein. (530 aa)
	ENSLCAP00010029854	ATPase family, AAA domain containing 5a. (1490 aa)
	ENSLCAP00010030201	Uncharacterized protein. (551 aa)
	ENSLCAP00010030207	Uncharacterized protein. (364 aa)
	ENSLCAP00010030304	Uncharacterized protein. (573 aa)
	LOC108876789	Ubiquitin-like domain-containing protein. (128 aa)
	kxd1	KxDL domain-containing protein. (184 aa)
	ENSLCAP00010032557	Uncharacterized protein. (554 aa)
	LOC108882294	Uncharacterized protein. (546 aa)
	LOC108898993	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (199 aa)
	LOC108880841	Uncharacterized protein. (611 aa)
	LOC108889329	Uncharacterized protein. (565 aa)
	ENSLCAP00010034121	Uncharacterized protein. (491 aa)
	LOC108890137	Uncharacterized protein. (550 aa)
	Rfc5	AAA domain-containing protein. (350 aa)
	LOC108893392	Uncharacterized protein. (574 aa)
	usp10	Ubiquitin carboxyl-terminal hydrolase. (883 aa)
	ENSLCAP00010036720	UmuC domain-containing protein. (598 aa)
	ENSLCAP00010037241	Uncharacterized protein. (251 aa)
	LOC108894959	Uncharacterized protein. (610 aa)
	ENSLCAP00010037776	Uncharacterized protein. (245 aa)
	ENSLCAP00010037799	Uncharacterized protein. (598 aa)
	LOC108892908	BTB domain-containing protein. (570 aa)
	Pole2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (513 aa)
	ENSLCAP00010040494	Uncharacterized protein. (205 aa)
	Ubb	Ubiquitin B. (517 aa)
	LOC108890922	Uncharacterized protein. (547 aa)
	LOC108890921	Uncharacterized protein. (547 aa)
	ENSLCAP00010040865	Uncharacterized protein. (492 aa)
	LOC108873867	Uncharacterized protein. (432 aa)
	LOC108890940	Uncharacterized protein. (569 aa)
	ENSLCAP00010045012	B30.2/SPRY domain-containing protein. (242 aa)
	LOC108898690	USP domain-containing protein; Belongs to the peptidase C19 family. (1220 aa)
	LOC108883656	Ubiquitin-like domain-containing protein. (128 aa)
	ENSLCAP00010046672	Ubiquitin-like domain-containing protein. (116 aa)
	LOC108876789-2	Ubiquitin-like domain-containing protein. (155 aa)
	ENSLCAP00010048234	Uncharacterized protein. (573 aa)
	ENSLCAP00010049090	Uncharacterized protein. (439 aa)
	rfc3	AAA domain-containing protein. (356 aa)
	ENSLCAP00010049633	PCNA clamp associated factor. (92 aa)
	LOC108895865	Uncharacterized protein. (429 aa)

Your Current Organism:

Lates calcarifer

NCBI taxonomy Id: 8187
Other names: Asian seabass, Holocentrus calcarifer, L. calcarifer, barramundi, barramundi perch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSLCAP00010005801	ENSLCAP00010036720	ENSLCAP00010005801	ENSLCAP00010036720	Ubiquitin specific peptidase 31; Belongs to the peptidase C19 family.	UmuC domain-containing protein.	0.481
ENSLCAP00010005801	ENSLCAP00010046672	ENSLCAP00010005801	ENSLCAP00010046672	Ubiquitin specific peptidase 31; Belongs to the peptidase C19 family.	Ubiquitin-like domain-containing protein.	0.565
ENSLCAP00010005801	Rev1	ENSLCAP00010005801	ENSLCAP00010014861	Ubiquitin specific peptidase 31; Belongs to the peptidase C19 family.	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family.	0.518
ENSLCAP00010005801	Rfc1	ENSLCAP00010005801	ENSLCAP00010002331	Ubiquitin specific peptidase 31; Belongs to the peptidase C19 family.	Replication factor C subunit 1.	0.498
ENSLCAP00010005801	Rfc2	ENSLCAP00010005801	ENSLCAP00010021203	Ubiquitin specific peptidase 31; Belongs to the peptidase C19 family.	Replication factor C (activator 1) 2.	0.505
ENSLCAP00010005801	Rfc5	ENSLCAP00010005801	ENSLCAP00010034522	Ubiquitin specific peptidase 31; Belongs to the peptidase C19 family.	AAA domain-containing protein.	0.521
ENSLCAP00010005801	Ubb	ENSLCAP00010005801	ENSLCAP00010040766	Ubiquitin specific peptidase 31; Belongs to the peptidase C19 family.	Ubiquitin B.	0.565
ENSLCAP00010005801	pcna	ENSLCAP00010005801	ENSLCAP00010007860	Ubiquitin specific peptidase 31; Belongs to the peptidase C19 family.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.558
ENSLCAP00010005801	polh	ENSLCAP00010005801	ENSLCAP00010024082	Ubiquitin specific peptidase 31; Belongs to the peptidase C19 family.	UmuC domain-containing protein.	0.534
ENSLCAP00010005801	polk	ENSLCAP00010005801	ENSLCAP00010060302	Ubiquitin specific peptidase 31; Belongs to the peptidase C19 family.	UmuC domain-containing protein.	0.512
ENSLCAP00010005801	rfc3	ENSLCAP00010005801	ENSLCAP00010049213	Ubiquitin specific peptidase 31; Belongs to the peptidase C19 family.	AAA domain-containing protein.	0.502
ENSLCAP00010005801	rfc4	ENSLCAP00010005801	ENSLCAP00010055666	Ubiquitin specific peptidase 31; Belongs to the peptidase C19 family.	AAA domain-containing protein.	0.508
ENSLCAP00010005801	rps27a	ENSLCAP00010005801	ENSLCAP00010005493	Ubiquitin specific peptidase 31; Belongs to the peptidase C19 family.	Ubiquitin-like domain-containing protein.	0.537
ENSLCAP00010005801	usp10	ENSLCAP00010005801	ENSLCAP00010035902	Ubiquitin specific peptidase 31; Belongs to the peptidase C19 family.	Ubiquitin carboxyl-terminal hydrolase.	0.610
ENSLCAP00010006675	ENSLCAP00010029854	ENSLCAP00010006675	ENSLCAP00010029854	Uncharacterized protein.	ATPase family, AAA domain containing 5a.	0.589
ENSLCAP00010006675	ENSLCAP00010036720	ENSLCAP00010006675	ENSLCAP00010036720	Uncharacterized protein.	UmuC domain-containing protein.	0.561
ENSLCAP00010006675	ENSLCAP00010046672	ENSLCAP00010006675	ENSLCAP00010046672	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.516
ENSLCAP00010006675	LOC108875967	ENSLCAP00010006675	ENSLCAP00010003251	Uncharacterized protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.991
ENSLCAP00010006675	LOC108876789	ENSLCAP00010006675	ENSLCAP00010031146	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.435
ENSLCAP00010006675	LOC108876789-2	ENSLCAP00010006675	ENSLCAP00010046809	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.435