(84 nodes) Signaling by MET network (Lates calcarifer)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSLCAP00010032567	Tyrosine-protein kinase. (526 aa)
	LOC108891917	Uncharacterized protein. (319 aa)
	Ranbp10	RAN binding protein 10. (651 aa)
	LOC108876789	Ubiquitin-like domain-containing protein. (128 aa)
	LOC108898162	Tyrosine-protein phosphatase non-receptor type. (393 aa)
	ENSLCAP00010029562	VHS domain-containing protein. (109 aa)
	stam2	Uncharacterized protein. (510 aa)
	fndc3b	Uncharacterized protein. (1186 aa)
	Cd2ap	CD2-associated protein. (621 aa)
	ENSLCAP00010026443	ADP-ribosylation factor 6a. (113 aa)
	ENSLCAP00010024755	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (710 aa)
	ENSLCAP00010003073	Uncharacterized protein. (992 aa)
	ENSLCAP00010003663	Fibrillar collagen NC1 domain-containing protein. (1368 aa)
	SHC4	SHC adaptor protein 4. (460 aa)
	ENSLCAP00010003783	Laminin, alpha 4. (1766 aa)
	Met	MET proto-oncogene, receptor tyrosine kinase. (1377 aa)
	LOC108902945	Uncharacterized protein. (324 aa)
	rps27a	Ubiquitin-like domain-containing protein. (156 aa)
	STAM2	Signal transducing adaptor molecule 2. (479 aa)
	LOC108884107	Uncharacterized protein. (185 aa)
	sh3d21	Uncharacterized protein. (493 aa)
	Fndc3a	Fibronectin type III domain containing 3A. (1213 aa)
	ENSLCAP00010008667	Laminin, beta 1a. (1792 aa)
	LOC108873688	PH domain-containing protein. (786 aa)
	Lamc1	Laminin, gamma 1. (1598 aa)
	LAMC2	Uncharacterized protein. (1133 aa)
	sh3gl2	Uncharacterized protein. (363 aa)
	CSDE1	Uncharacterized protein. (913 aa)
	LOC108879160	Uncharacterized protein. (1060 aa)
	LOC108882207	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
	cbl	Uncharacterized protein. (958 aa)
	LOC108880525	Uncharacterized protein. (384 aa)
	rap1b	Uncharacterized protein. (188 aa)
	tns4	SH2 domain-containing protein. (566 aa)
	TNS3	Uncharacterized protein. (1403 aa)
	LAMA3	Laminin subunit alpha 3. (2779 aa)
	Dock7	Dedicator of cytokinesis 7; Belongs to the DOCK family. (2136 aa)
	Spint1	Serine peptidase inhibitor, Kunitz type 1 a. (491 aa)
	crkl	Uncharacterized protein. (306 aa)
	ENSLCAP00010000123	Cbl proto-oncogene C, E3 ubiquitin protein ligase. (533 aa)
	grb2	Uncharacterized protein. (217 aa)
	LOC108886836	Uncharacterized protein. (353 aa)
	crk	Uncharacterized protein. (315 aa)
	ENSLCAP00010001305	SH3-domain kinase binding protein 1. (624 aa)
	ENSLCAP00010001528	Laminin, gamma 3. (1030 aa)
	ranbp9	Uncharacterized protein. (601 aa)
	LOC108892325	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1070 aa)
	LOC108888321	Uncharacterized protein. (341 aa)
	rapgef1	Uncharacterized protein. (1100 aa)
	ENSLCAP00010057781	Epidermal growth factor receptor pathway substrate 15. (944 aa)
	Lamb2	Laminin, beta 2 (laminin S). (1788 aa)
	ENSLCAP00010056969	Laminin, alpha 5. (1650 aa)
	hgs	Uncharacterized protein. (811 aa)
	Rab4a	RAB4a, member RAS oncogene family. (218 aa)
	LOC108893685	Uncharacterized protein. (864 aa)
	LOC108895090	Tyrosine-protein kinase. (543 aa)
	LOC108877358	Uncharacterized protein. (351 aa)
	shc1	Uncharacterized protein. (596 aa)
	ENSLCAP00010053299	Ggolgi-associated, gamma adaptin ear containing, ARF binding protein 3. (621 aa)
	ENSLCAP00010052333	Fibrillar collagen NC1 domain-containing protein. (148 aa)
	LOC108883763	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	ENSLCAP00010051319	N-terminal Ras-GEF domain-containing protein. (688 aa)
	lrig1	Uncharacterized protein. (1048 aa)
	ENSLCAP00010048292	Tensin 1b. (1602 aa)
	LOC108880106	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	LOC108876789-2	Ubiquitin-like domain-containing protein. (155 aa)
	ENSLCAP00010046672	Ubiquitin-like domain-containing protein. (116 aa)
	LOC108883656	Ubiquitin-like domain-containing protein. (128 aa)
	Arf6	Uncharacterized protein. (111 aa)
	ENSLCAP00010045441	Tensin 1. (1533 aa)
	stam	Uncharacterized protein. (521 aa)
	ptpn2	Tyrosine-protein phosphatase non-receptor type. (419 aa)
	gab1	PH domain-containing protein. (758 aa)
	ENSLCAP00010041386	Zgc:55558. (187 aa)
	Ubb	Ubiquitin B. (517 aa)
	LOC108900813	Uncharacterized protein. (224 aa)
	ENSLCAP00010039782	Uncharacterized protein. (1576 aa)
	hras	Uncharacterized protein. (189 aa)
	ENSLCAP00010035999	Fibrillar collagen NC1 domain-containing protein. (112 aa)
	kras	Uncharacterized protein. (189 aa)
	LOC108890490	Uncharacterized protein. (185 aa)
	hpn	Uncharacterized protein; Belongs to the peptidase S1 family. (427 aa)
	LOC108890482	Tyrosine-protein phosphatase non-receptor type. (435 aa)
	ENSLCAP00010035172	Laminin, alpha 1. (2542 aa)

Your Current Organism:

Lates calcarifer

NCBI taxonomy Id: 8187
Other names: Asian seabass, Holocentrus calcarifer, L. calcarifer, barramundi, barramundi perch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Arf6	ENSLCAP00010024755	ENSLCAP00010045797	ENSLCAP00010024755	Uncharacterized protein.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.426
Arf6	ENSLCAP00010029562	ENSLCAP00010045797	ENSLCAP00010029562	Uncharacterized protein.	VHS domain-containing protein.	0.818
Arf6	ENSLCAP00010053299	ENSLCAP00010045797	ENSLCAP00010053299	Uncharacterized protein.	Ggolgi-associated, gamma adaptin ear containing, ARF binding protein 3.	0.818
Arf6	LOC108873688	ENSLCAP00010045797	ENSLCAP00010008961	Uncharacterized protein.	PH domain-containing protein.	0.520
Arf6	LOC108891917	ENSLCAP00010045797	ENSLCAP00010032312	Uncharacterized protein.	Uncharacterized protein.	0.555
Arf6	LOC108900813	ENSLCAP00010045797	ENSLCAP00010040624	Uncharacterized protein.	Uncharacterized protein.	0.475
Arf6	Met	ENSLCAP00010045797	ENSLCAP00010004840	Uncharacterized protein.	MET proto-oncogene, receptor tyrosine kinase.	0.753
Arf6	Rab4a	ENSLCAP00010045797	ENSLCAP00010056527	Uncharacterized protein.	RAB4a, member RAS oncogene family.	0.475
Arf6	crk	ENSLCAP00010045797	ENSLCAP00010000564	Uncharacterized protein.	Uncharacterized protein.	0.555
Arf6	crkl	ENSLCAP00010045797	ENSLCAP00010024452	Uncharacterized protein.	Uncharacterized protein.	0.555
Arf6	gab1	ENSLCAP00010045797	ENSLCAP00010042744	Uncharacterized protein.	PH domain-containing protein.	0.520
Arf6	grb2	ENSLCAP00010045797	ENSLCAP00010000204	Uncharacterized protein.	Uncharacterized protein.	0.620
CSDE1	ENSLCAP00010032567	ENSLCAP00010012243	ENSLCAP00010032567	Uncharacterized protein.	Tyrosine-protein kinase.	0.418
CSDE1	ENSLCAP00010046672	ENSLCAP00010012243	ENSLCAP00010046672	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.447
CSDE1	ENSLCAP00010051319	ENSLCAP00010012243	ENSLCAP00010051319	Uncharacterized protein.	N-terminal Ras-GEF domain-containing protein.	0.405
CSDE1	LOC108876789	ENSLCAP00010012243	ENSLCAP00010031146	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.427
CSDE1	LOC108876789-2	ENSLCAP00010012243	ENSLCAP00010046809	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.427
CSDE1	LOC108880106	ENSLCAP00010012243	ENSLCAP00010047146	Uncharacterized protein.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.531
CSDE1	LOC108882207	ENSLCAP00010012243	ENSLCAP00010015383	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.531
CSDE1	LOC108883656	ENSLCAP00010012243	ENSLCAP00010046378	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.427