STRINGSTRING
Cdt1 Cdt1 ENSLCAP00010002675 ENSLCAP00010002675 LOC108875967 LOC108875967 dbf4 dbf4 ENSLCAP00010005350 ENSLCAP00010005350 ENSLCAP00010006345 ENSLCAP00010006345 ENSLCAP00010006675 ENSLCAP00010006675 Orc5 Orc5 cdc45 cdc45 pola2 pola2 mcm6 mcm6 ENSLCAP00010008769 ENSLCAP00010008769 pole3 pole3 mcm4 mcm4 mcm3 mcm3 ENSLCAP00010011831 ENSLCAP00010011831 rpa3 rpa3 cdk2 cdk2 LOC108883334 LOC108883334 mcm2 mcm2 rpa2 rpa2 mcm9 mcm9 Orc4 Orc4 gmnn gmnn Pole2 Pole2 prim1 prim1 cdk2-2 cdk2-2 mcm5 mcm5 Orc3 Orc3 mcm10 mcm10 mcm7 mcm7 cdc7 cdc7 RPA1 RPA1 ENSLCAP00010055640 ENSLCAP00010055640 ENSLCAP00010055815 ENSLCAP00010055815 pole4 pole4 LOC108881387 LOC108881387 LOC108882499 LOC108882499 Prim2 Prim2 meiob meiob pole pole
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Cdt1Chromatin licensing and DNA replication factor 1. (482 aa)
ENSLCAP00010002675Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (556 aa)
LOC108875967Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (606 aa)
dbf4Uncharacterized protein. (628 aa)
ENSLCAP00010005350Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (806 aa)
ENSLCAP00010006345Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (869 aa)
ENSLCAP00010006675Uncharacterized protein. (176 aa)
Orc5Origin recognition complex, subunit 5. (449 aa)
cdc45Uncharacterized protein. (568 aa)
pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (602 aa)
mcm6DNA helicase; Belongs to the MCM family. (832 aa)
ENSLCAP00010008769Origin recognition complex, subunit 2. (534 aa)
pole3CBFD_NFYB_HMF domain-containing protein. (149 aa)
mcm4DNA helicase; Belongs to the MCM family. (860 aa)
mcm3DNA helicase; Belongs to the MCM family. (815 aa)
ENSLCAP00010011831DNA polymerase. (1466 aa)
rpa3Uncharacterized protein. (122 aa)
cdk2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (298 aa)
LOC108883334Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (940 aa)
mcm2DNA helicase; Belongs to the MCM family. (916 aa)
rpa2RPA_C domain-containing protein. (290 aa)
mcm9MCM domain-containing protein; Belongs to the MCM family. (1238 aa)
Orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (462 aa)
gmnnUncharacterized protein. (234 aa)
Pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (513 aa)
prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (424 aa)
cdk2-2Cyclin-dependent kinase 2. (298 aa)
mcm5DNA helicase; Belongs to the MCM family. (737 aa)
Orc3Origin recognition complex, subunit 3. (712 aa)
mcm10Mcm10 domain-containing protein. (908 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (729 aa)
cdc7Protein kinase domain-containing protein. (610 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (678 aa)
ENSLCAP00010055640annotation not available (277 aa)
ENSLCAP00010055815Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (285 aa)
pole4CBFD_NFYB_HMF domain-containing protein. (129 aa)
LOC108881387SCY domain-containing protein. (125 aa)
LOC108882499Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (573 aa)
Prim2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (502 aa)
meiobUncharacterized protein. (460 aa)
poleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2296 aa)
Your Current Organism:
Lates calcarifer
NCBI taxonomy Id: 8187
Other names: Asian seabass, Holocentrus calcarifer, L. calcarifer, barramundi, barramundi perch
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