125 items (Lates calcarifer) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	mcm9	MCM domain-containing protein; Belongs to the MCM family. (1238 aa)
	mcm2	DNA helicase; Belongs to the MCM family. (916 aa)
	LOC108900731	F-box domain-containing protein. (421 aa)
	Anapc2	Anaphase promoting complex subunit 2; Belongs to the cullin family. (872 aa)
	cdc16	TPR_REGION domain-containing protein. (620 aa)
	rbx1	RING-type domain-containing protein. (108 aa)
	psmf1	Uncharacterized protein. (277 aa)
	psma8	Proteasome subunit alpha type. (251 aa)
	anapc11	RING-type domain-containing protein. (84 aa)
	psmb3	Proteasome subunit beta. (205 aa)
	ccne1	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (433 aa)
	psmd6	PCI domain-containing protein. (397 aa)
	LOC108884668	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (395 aa)
	LOC108888424	Proteasome subunit beta. (275 aa)
	LOC108888423	Proteasome subunit beta. (275 aa)
	LOC108888425	Uncharacterized protein. (217 aa)
	LOC108881898	Proteasome subunit beta. (216 aa)
	ube2s	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (236 aa)
	LOC108873252	PCI domain-containing protein. (520 aa)
	LOC108883334	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (940 aa)
	psmd14	MPN domain-containing protein. (310 aa)
	LOC108883948	Proteasome subunit beta. (271 aa)
	LOC108883947	Uncharacterized protein. (355 aa)
	cdc23	Uncharacterized protein. (600 aa)
	cdk2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (298 aa)
	ENSLCAP00010013668	PROTEASOME_ALPHA_1 domain-containing protein. (104 aa)
	cdc26	Uncharacterized protein. (95 aa)
	bicra	GLTSCR1 domain-containing protein. (1918 aa)
	psmd8	PCI domain-containing protein. (290 aa)
	mcm3	DNA helicase; Belongs to the MCM family. (815 aa)
	mcm4	DNA helicase; Belongs to the MCM family. (860 aa)
	Psmd10	Proteasome 26S subunit, non-ATPase 10. (228 aa)
	LOC108895836	Proteasome endopeptidase complex. (295 aa)
	psmd13	PCI domain-containing protein. (399 aa)
	ENSLCAP00010008769	Origin recognition complex, subunit 2. (534 aa)
	psmc1	AAA domain-containing protein; Belongs to the AAA ATPase family. (440 aa)
	mcm6	DNA helicase; Belongs to the MCM family. (832 aa)
	LOC108883014	Proteasome subunit alpha type. (261 aa)
	Orc5	Origin recognition complex, subunit 5. (449 aa)
	ENSLCAP00010006513	Uncharacterized protein. (348 aa)
	ENSLCAP00010006345	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (869 aa)
	LOC108874380	Uncharacterized protein. (256 aa)
	psma1	Proteasome subunit alpha type. (262 aa)
	rps27a	Ubiquitin-like domain-containing protein. (156 aa)
	Psme1	Proteasome activator subunit 1. (265 aa)
	ENSLCAP00010005350	Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (806 aa)
	anapc10	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (186 aa)
	ENSLCAP00010004085	Proteasome subunit beta 6. (497 aa)
	psmc4	AAA domain-containing protein; Belongs to the AAA ATPase family. (417 aa)
	psmd5	Uncharacterized protein. (504 aa)
	LOC108883827	WD_REPEATS_REGION domain-containing protein. (487 aa)
	PSMD3	PCI domain-containing protein. (534 aa)
	ENSLCAP00010002675	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (556 aa)
	Cdt1	Chromatin licensing and DNA replication factor 1. (482 aa)
	psmd1	26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (961 aa)
	PSME3	Proteasome activator subunit 3. (272 aa)
	psma5	Proteasome subunit alpha type. (241 aa)
	Psmc6	Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (421 aa)
	Psmb7	Proteasome subunit beta. (305 aa)
	ENSLCAP00010027853	Proteasome 26S subunit, non-ATPase 7. (337 aa)
	skp1	Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
	Orc4	Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (462 aa)
	CCNE2	Cyclin E2; Belongs to the cyclin family. (394 aa)
	gmnn	Uncharacterized protein. (234 aa)
	ENSLCAP00010029805	Proteasome 26S subunit, non-ATPase 11b. (439 aa)
	Gltscr1l	BRD4 interacting chromatin remodeling complex associated protein like. (663 aa)
	LOC108876789	Ubiquitin-like domain-containing protein. (128 aa)
	ENSLCAP00010031434	Proteasome subunit beta11b. (302 aa)
	LOC108889618	VWFA domain-containing protein. (375 aa)
	kxd1	KxDL domain-containing protein. (184 aa)
	anapc4	Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (804 aa)
	LOC108883136	Proteasome subunit alpha type. (246 aa)
	psmc5	AAA domain-containing protein; Belongs to the AAA ATPase family. (406 aa)
	psmc2	AAA domain-containing protein; Belongs to the AAA ATPase family. (433 aa)
	psme4	Uncharacterized protein. (1847 aa)
	FZR1	WD_REPEATS_REGION domain-containing protein. (496 aa)
	psma2	Proteasome subunit alpha type. (234 aa)
	LOC108898553	Uncharacterized protein. (256 aa)
	PSMD11	Proteasome 26S subunit, non-ATPase 11. (461 aa)
	fam89a	Uncharacterized protein. (178 aa)
	Ubb	Ubiquitin B. (517 aa)
	PSMA4	Proteasome subunit alpha type. (261 aa)
	ENSLCAP00010042538	Anaphase promoting complex subunit 1. (1892 aa)
	cdc27	Uncharacterized protein. (808 aa)
	ENSLCAP00010043392	Rpn3_C domain-containing protein. (104 aa)
	anapc16	Uncharacterized protein. (108 aa)
	LOC108883136-2	Proteasome subunit alpha type-6-like. (246 aa)
	LOC108894001	Uncharacterized protein. (189 aa)
	cdk2-2	Cyclin-dependent kinase 2. (298 aa)
	LOC108881898-2	Proteasome subunit beta type-9. (216 aa)
	LOC108881905	Uncharacterized protein. (217 aa)
	LOC108881904	Proteasome subunit beta. (275 aa)
	LOC108881903	Proteasome subunit beta. (275 aa)
	anapc5	Uncharacterized protein. (773 aa)
	mcm5	DNA helicase; Belongs to the MCM family. (737 aa)
	Orc3	Origin recognition complex, subunit 3. (712 aa)
	anapc15	Uncharacterized protein. (122 aa)
	LOC108877696	Proteasome subunit beta. (278 aa)
	LOC108883656	Ubiquitin-like domain-containing protein. (128 aa)
	psmb2	Proteasome subunit beta. (199 aa)
	ENSLCAP00010046672	Ubiquitin-like domain-containing protein. (116 aa)
	psmb4	Proteasome subunit beta; Belongs to the peptidase T1B family. (262 aa)
	LOC108876789-2	Ubiquitin-like domain-containing protein. (155 aa)
	ccna1	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (416 aa)
	mcm7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (729 aa)
	Psma6	Proteasome subunit alpha type. (204 aa)
	LOC108888868	VWFA domain-containing protein. (372 aa)
	ENSLCAP00010049581	Uncharacterized protein. (1795 aa)
	ube2c	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (174 aa)
	Psmd12	Proteasome 26S subunit, non-ATPase 12. (456 aa)
	LOC108881353	WD_REPEATS_REGION domain-containing protein. (495 aa)
	cul1	CULLIN_2 domain-containing protein; Belongs to the cullin family. (776 aa)
	ENSLCAP00010055640	annotation not available (277 aa)
	ENSLCAP00010055815	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (285 aa)
	tm7sf3	DUF4203 domain-containing protein. (565 aa)
	ccna2	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (436 aa)
	Psmc3	Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (436 aa)
	Psmb1	Proteasome subunit beta. (243 aa)
	psme2	Uncharacterized protein. (341 aa)
	LOC108889222	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (201 aa)
	psma3	Proteasome subunit alpha type. (255 aa)
	LOC108882499	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (573 aa)
	anapc7	Uncharacterized protein. (574 aa)
	ENSLCAP00010060028	Proteasome activator subunit 3. (272 aa)
	psmd9	PDZ domain-containing protein. (212 aa)

Your Current Organism:

Lates calcarifer

NCBI taxonomy Id: 8187
Other names: Asian seabass, Holocentrus calcarifer, L. calcarifer, barramundi, barramundi perch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Anapc2	ENSLCAP00010002675	ENSLCAP00010023649	ENSLCAP00010002675	Anaphase promoting complex subunit 2; Belongs to the cullin family.	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	0.599
Anapc2	ENSLCAP00010029805	ENSLCAP00010023649	ENSLCAP00010029805	Anaphase promoting complex subunit 2; Belongs to the cullin family.	Proteasome 26S subunit, non-ATPase 11b.	0.588
Anapc2	ENSLCAP00010031434	ENSLCAP00010023649	ENSLCAP00010031434	Anaphase promoting complex subunit 2; Belongs to the cullin family.	Proteasome subunit beta11b.	0.436
Anapc2	ENSLCAP00010042538	ENSLCAP00010023649	ENSLCAP00010042538	Anaphase promoting complex subunit 2; Belongs to the cullin family.	Anaphase promoting complex subunit 1.	0.999
Anapc2	ENSLCAP00010046672	ENSLCAP00010023649	ENSLCAP00010046672	Anaphase promoting complex subunit 2; Belongs to the cullin family.	Ubiquitin-like domain-containing protein.	0.831
Anapc2	ENSLCAP00010055640	ENSLCAP00010023649	ENSLCAP00010055640	Anaphase promoting complex subunit 2; Belongs to the cullin family.	annotation not available	0.471
Anapc2	ENSLCAP00010055815	ENSLCAP00010023649	ENSLCAP00010055815	Anaphase promoting complex subunit 2; Belongs to the cullin family.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.471
Anapc2	FZR1	ENSLCAP00010023649	ENSLCAP00010035104	Anaphase promoting complex subunit 2; Belongs to the cullin family.	WD_REPEATS_REGION domain-containing protein.	0.986
Anapc2	Gltscr1l	ENSLCAP00010023649	ENSLCAP00010030117	Anaphase promoting complex subunit 2; Belongs to the cullin family.	BRD4 interacting chromatin remodeling complex associated protein like.	0.949
Anapc2	LOC108876789	ENSLCAP00010023649	ENSLCAP00010031146	Anaphase promoting complex subunit 2; Belongs to the cullin family.	Ubiquitin-like domain-containing protein.	0.814
Anapc2	LOC108876789-2	ENSLCAP00010023649	ENSLCAP00010046809	Anaphase promoting complex subunit 2; Belongs to the cullin family.	Ubiquitin-like domain-containing protein.	0.814
Anapc2	LOC108881353	ENSLCAP00010023649	ENSLCAP00010054207	Anaphase promoting complex subunit 2; Belongs to the cullin family.	WD_REPEATS_REGION domain-containing protein.	0.986
Anapc2	LOC108881903	ENSLCAP00010023649	ENSLCAP00010044848	Anaphase promoting complex subunit 2; Belongs to the cullin family.	Proteasome subunit beta.	0.444
Anapc2	LOC108882499	ENSLCAP00010023649	ENSLCAP00010059323	Anaphase promoting complex subunit 2; Belongs to the cullin family.	Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.	0.599
Anapc2	LOC108883656	ENSLCAP00010023649	ENSLCAP00010046378	Anaphase promoting complex subunit 2; Belongs to the cullin family.	Ubiquitin-like domain-containing protein.	0.814
Anapc2	LOC108883827	ENSLCAP00010023649	ENSLCAP00010002941	Anaphase promoting complex subunit 2; Belongs to the cullin family.	WD_REPEATS_REGION domain-containing protein.	0.986
Anapc2	LOC108883947	ENSLCAP00010023649	ENSLCAP00010015562	Anaphase promoting complex subunit 2; Belongs to the cullin family.	Uncharacterized protein.	0.436
Anapc2	LOC108883948	ENSLCAP00010023649	ENSLCAP00010015575	Anaphase promoting complex subunit 2; Belongs to the cullin family.	Proteasome subunit beta.	0.444
Anapc2	LOC108884668	ENSLCAP00010023649	ENSLCAP00010019748	Anaphase promoting complex subunit 2; Belongs to the cullin family.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.650
Anapc2	LOC108888424	ENSLCAP00010023649	ENSLCAP00010019687	Anaphase promoting complex subunit 2; Belongs to the cullin family.	Proteasome subunit beta.	0.444