STRINGSTRING
LOC108883014 LOC108883014 LOC108888178 LOC108888178 ENSLCAP00010001230 ENSLCAP00010001230 ENSLCAP00010001731 ENSLCAP00010001731 kat5 kat5 ENSLCAP00010002675 ENSLCAP00010002675 PSMD3 PSMD3 LOC108875967 LOC108875967 dbf4 dbf4 psmd5 psmd5 psmc4 psmc4 ENSLCAP00010004085 ENSLCAP00010004085 ENSLCAP00010004286 ENSLCAP00010004286 Rnf168 Rnf168 ENSLCAP00010005350 ENSLCAP00010005350 Psme1 Psme1 rps27a rps27a rhno1 rhno1 wee1 wee1 psma1 psma1 Rmi2 Rmi2 brca1 brca1 ENSLCAP00010006345 ENSLCAP00010006345 ENSLCAP00010006513 ENSLCAP00010006513 Rbbp8 Rbbp8 ENSLCAP00010006661 ENSLCAP00010006661 ENSLCAP00010006675 ENSLCAP00010006675 Orc5 Orc5 cdc45 cdc45 LOC108876221 LOC108876221 ENSLCAP00010008081 ENSLCAP00010008081 ENSLCAP00010008183 ENSLCAP00010008183 mcm6 mcm6 psmc1 psmc1 ENSLCAP00010008769 ENSLCAP00010008769 psmd13 psmd13 LOC108895836 LOC108895836 ENSLCAP00010009091 ENSLCAP00010009091 Mdc1 Mdc1 CCNB2 CCNB2 Psmd10 Psmd10 ENSLCAP00010009839 ENSLCAP00010009839 ENSLCAP00010010086 ENSLCAP00010010086 ENSLCAP00010010263 ENSLCAP00010010263 blm blm ube2v2 ube2v2 Rad1 Rad1 mcm4 mcm4 mcm3 mcm3 rpa3 rpa3 psmd8 psmd8 ankrd11 ankrd11 ENSLCAP00010013279 ENSLCAP00010013279 LOC108890157 LOC108890157 ENSLCAP00010013668 ENSLCAP00010013668 ENSLCAP00010013869 ENSLCAP00010013869 cdk2 cdk2 babam1 babam1 ENSLCAP00010015456 ENSLCAP00010015456 LOC108883947 LOC108883947 LOC108883948 LOC108883948 hus1 hus1 LOC108879980 LOC108879980 psmd14 psmd14 ENSLCAP00010017449 ENSLCAP00010017449 LOC108883334 LOC108883334 LOC108901366 LOC108901366 ENSLCAP00010018208 ENSLCAP00010018208 tdrd3 tdrd3 ENSLCAP00010018730 ENSLCAP00010018730 ENSLCAP00010018773 ENSLCAP00010018773 ENSLCAP00010018791 ENSLCAP00010018791 RCBTB1 RCBTB1 LOC108873252 LOC108873252 LOC108881898 LOC108881898 LOC108888425 LOC108888425 LOC108888424 LOC108888424 chek1 chek1 psmd6 psmd6 Rfc2 Rfc2 exd2 exd2 LOC108890174 LOC108890174 ENSLCAP00010021619 ENSLCAP00010021619 psmb3 psmb3 psma8 psma8 Fam175a Fam175a Wdr41 Wdr41 psmf1 psmf1 Top3a Top3a rad9a rad9a mcm2 mcm2 rpa2 rpa2 psmd1 psmd1 PSME3 PSME3 psma5 psma5 Psmc6 Psmc6 Psmb7 Psmb7 LOC108873640 LOC108873640 LOC108901759 LOC108901759 ENSLCAP00010026411 ENSLCAP00010026411 ENSLCAP00010026416 ENSLCAP00010026416 LOC108876085 LOC108876085 LOC108901759-2 LOC108901759-2 cdca7l cdca7l LOC108873640-2 LOC108873640-2 mcm9 mcm9 ENSLCAP00010027853 ENSLCAP00010027853 Cdc25b Cdc25b Cdk1 Cdk1 Orc4 Orc4 ENSLCAP00010029188 ENSLCAP00010029188 ENSLCAP00010029462 ENSLCAP00010029462 ENSLCAP00010029487 ENSLCAP00010029487 ENSLCAP00010029519 ENSLCAP00010029519 ENSLCAP00010029533 ENSLCAP00010029533 ENSLCAP00010029538 ENSLCAP00010029538 ENSLCAP00010029546 ENSLCAP00010029546 ENSLCAP00010029552 ENSLCAP00010029552 ENSLCAP00010029557 ENSLCAP00010029557 rnf169 rnf169 LOC108889333 LOC108889333 ENSLCAP00010029805 ENSLCAP00010029805 LOC108898131 LOC108898131 ENSLCAP00010031434 ENSLCAP00010031434 ENSLCAP00010031718 ENSLCAP00010031718 LOC108889618 LOC108889618 LOC108891918 LOC108891918 kxd1 kxd1 LOC108883136 LOC108883136 ENSLCAP00010032855 ENSLCAP00010032855 psmc5 psmc5 YWHAB YWHAB psmc2 psmc2 BRCC3 BRCC3 psme4 psme4 ENSLCAP00010034255 ENSLCAP00010034255 Rfc5 Rfc5 ENSLCAP00010034591 ENSLCAP00010034591 LOC108890486 LOC108890486 Mre11 Mre11 psma2 psma2 atrip atrip LOC108893914 LOC108893914 LOC108892908 LOC108892908 PSMD11 PSMD11 Ubb Ubb LOC108900816 LOC108900816 PSMA4 PSMA4 rnf8 rnf8 LOC108873639 LOC108873639 LOC108884383 LOC108884383 Cdca7l Cdca7l ENSLCAP00010042963 ENSLCAP00010042963 ENSLCAP00010042987 ENSLCAP00010042987 ENSLCAP00010042999 ENSLCAP00010042999 LOC108876274 LOC108876274 rad50 rad50 ENSLCAP00010043392 ENSLCAP00010043392 LOC108883136-2 LOC108883136-2 cdk2-2 cdk2-2 LOC108881898-2 LOC108881898-2 LOC108881905 LOC108881905 LOC108881903 LOC108881903 mcm5 mcm5 Orc3 Orc3 mcm10 mcm10 LOC108877696 LOC108877696 psmb2 psmb2 ENSLCAP00010046672 ENSLCAP00010046672 psmb4 psmb4 ENSLCAP00010046789 ENSLCAP00010046789 ENSLCAP00010046942 ENSLCAP00010046942 Bre Bre mcm7 mcm7 Psma6 Psma6 LOC108888868 LOC108888868 cdc7 cdc7 ywhaq ywhaq rfc3 rfc3 ccnb1 ccnb1 ENSLCAP00010049581 ENSLCAP00010049581 ENSLCAP00010050470 ENSLCAP00010050470 ENSLCAP00010050501 ENSLCAP00010050501 LOC108873640-3 LOC108873640-3 LOC108878669 LOC108878669 ENSLCAP00010051639 ENSLCAP00010051639 RPA1 RPA1 ankrd12 ankrd12 ccnb3 ccnb3 PIEZO2 PIEZO2 Psmd12 Psmd12 ENSLCAP00010054492 ENSLCAP00010054492 ENSLCAP00010055640 ENSLCAP00010055640 rfc4 rfc4 ENSLCAP00010055815 ENSLCAP00010055815 Cdca7 Cdca7 Dna2 Dna2 Psmc3 Psmc3 Psmb1 Psmb1 psme2 psme2 psma3 psma3 LOC108882499 LOC108882499 rad9b rad9b Slf1 Slf1 ENSLCAP00010060028 ENSLCAP00010060028 meiob meiob psmd9 psmd9 rmi1 rmi1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC108883014Proteasome subunit alpha type. (261 aa)
LOC10888817814_3_3 domain-containing protein; Belongs to the 14-3-3 family. (255 aa)
ENSLCAP00010001230Nuclear receptor binding SET domain protein 2. (1162 aa)
ENSLCAP00010001731Uncharacterized protein. (1947 aa)
kat5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (578 aa)
ENSLCAP00010002675Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (556 aa)
PSMD3PCI domain-containing protein. (534 aa)
LOC108875967Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (606 aa)
dbf4Uncharacterized protein. (628 aa)
psmd5Uncharacterized protein. (504 aa)
psmc4AAA domain-containing protein; Belongs to the AAA ATPase family. (417 aa)
ENSLCAP00010004085Proteasome subunit beta 6. (497 aa)
ENSLCAP00010004286Wee1-like protein kinase. (540 aa)
Rnf168Ring finger protein 168. (381 aa)
ENSLCAP00010005350Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (806 aa)
Psme1Proteasome activator subunit 1. (265 aa)
rps27aUbiquitin-like domain-containing protein. (156 aa)
rhno1Uncharacterized protein. (300 aa)
wee1Wee1-like protein kinase. (620 aa)
psma1Proteasome subunit alpha type. (262 aa)
Rmi2RecQ mediated genome instability 2. (91 aa)
brca1Uncharacterized protein. (1411 aa)
ENSLCAP00010006345Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (869 aa)
ENSLCAP00010006513Uncharacterized protein. (348 aa)
Rbbp8SAE2 domain-containing protein. (73 aa)
ENSLCAP00010006661Piezo-type mechanosensitive ion channel component. (2201 aa)
ENSLCAP00010006675Uncharacterized protein. (176 aa)
Orc5Origin recognition complex, subunit 5. (449 aa)
cdc45Uncharacterized protein. (568 aa)
LOC108876221BTB domain-containing protein. (546 aa)
ENSLCAP00010008081Tumor protein p53 binding protein, 1. (1495 aa)
ENSLCAP00010008183RecQ helicase-like 4. (1236 aa)
mcm6DNA helicase; Belongs to the MCM family. (832 aa)
psmc1AAA domain-containing protein; Belongs to the AAA ATPase family. (440 aa)
ENSLCAP00010008769Origin recognition complex, subunit 2. (534 aa)
psmd13PCI domain-containing protein. (399 aa)
LOC108895836Proteasome endopeptidase complex. (295 aa)
ENSLCAP00010009091Histone H2B; Belongs to the histone H2B family. (67 aa)
Mdc1Uncharacterized protein. (2161 aa)
CCNB2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (397 aa)
Psmd10Proteasome 26S subunit, non-ATPase 10. (228 aa)
ENSLCAP00010009839Cyclin B2; Belongs to the cyclin family. (315 aa)
ENSLCAP00010010086Uncharacterized protein. (497 aa)
ENSLCAP00010010263Histone H2B; Belongs to the histone H2B family. (117 aa)
blmUncharacterized protein. (1413 aa)
ube2v2UBIQUITIN_CONJUGAT_2 domain-containing protein. (175 aa)
Rad1RAD1 homolog (S. pombe). (329 aa)
mcm4DNA helicase; Belongs to the MCM family. (860 aa)
mcm3DNA helicase; Belongs to the MCM family. (815 aa)
rpa3Uncharacterized protein. (122 aa)
psmd8PCI domain-containing protein. (290 aa)
ankrd11ANK_REP_REGION domain-containing protein. (2872 aa)
ENSLCAP00010013279Protein inhibitor of activated STAT, 4a. (491 aa)
LOC108890157UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
ENSLCAP00010013668PROTEASOME_ALPHA_1 domain-containing protein. (104 aa)
ENSLCAP00010013869Protein kinase, membrane associated tyrosine/threonine 1; Belongs to the protein kinase superfamily. (436 aa)
cdk2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (298 aa)
babam1Uncharacterized protein. (377 aa)
ENSLCAP00010015456Si:ch211-132b12.8; Belongs to the cyclin family. (361 aa)
LOC108883947Uncharacterized protein. (355 aa)
LOC108883948Proteasome subunit beta. (271 aa)
hus1Checkpoint protein; Belongs to the HUS1 family. (285 aa)
LOC108879980Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (380 aa)
psmd14MPN domain-containing protein. (310 aa)
ENSLCAP00010017449Uncharacterized protein. (477 aa)
LOC108883334Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (940 aa)
LOC108901366Histone H2B; Belongs to the histone H2B family. (124 aa)
ENSLCAP00010018208Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (80 aa)
tdrd3Uncharacterized protein. (785 aa)
ENSLCAP00010018730Uncharacterized protein; Belongs to the histone H2A family. (242 aa)
ENSLCAP00010018773Uncharacterized protein; Belongs to the histone H2A family. (244 aa)
ENSLCAP00010018791Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (97 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (508 aa)
LOC108873252PCI domain-containing protein. (520 aa)
LOC108881898Proteasome subunit beta. (216 aa)
LOC108888425Uncharacterized protein. (217 aa)
LOC108888424Proteasome subunit beta. (275 aa)
chek1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (486 aa)
psmd6PCI domain-containing protein. (397 aa)
Rfc2Replication factor C (activator 1) 2. (444 aa)
exd23'-5' exonuclease domain-containing protein. (639 aa)
LOC108890174Histone H2B; Belongs to the histone H2B family. (143 aa)
ENSLCAP00010021619Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa)
psmb3Proteasome subunit beta. (205 aa)
psma8Proteasome subunit alpha type. (251 aa)
Fam175aAbraxas 1, BRCA1 A complex subunit. (252 aa)
Wdr41WD_REPEATS_REGION domain-containing protein. (160 aa)
psmf1Uncharacterized protein. (277 aa)
Top3aDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1041 aa)
rad9aCell cycle checkpoint control protein; Belongs to the rad9 family. (393 aa)
mcm2DNA helicase; Belongs to the MCM family. (916 aa)
rpa2RPA_C domain-containing protein. (290 aa)
psmd126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (961 aa)
PSME3Proteasome activator subunit 3. (272 aa)
psma5Proteasome subunit alpha type. (241 aa)
Psmc6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (421 aa)
Psmb7Proteasome subunit beta. (305 aa)
LOC108873640Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
LOC108901759Histone H2B; Belongs to the histone H2B family. (124 aa)
ENSLCAP00010026411Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (92 aa)
ENSLCAP00010026416annotation not available (67 aa)
LOC10887608514_3_3 domain-containing protein; Belongs to the 14-3-3 family. (247 aa)
LOC108901759-2Histone H2B 1/2-like. (124 aa)
cdca7lzf-4CXXC_R1 domain-containing protein. (417 aa)
LOC108873640-2Histone H4. (103 aa)
mcm9MCM domain-containing protein; Belongs to the MCM family. (1238 aa)
ENSLCAP00010027853Proteasome 26S subunit, non-ATPase 7. (337 aa)
Cdc25bRhodanese domain-containing protein. (385 aa)
Cdk1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (331 aa)
Orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (462 aa)
ENSLCAP00010029188ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2552 aa)
ENSLCAP00010029462Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (92 aa)
ENSLCAP00010029487Histone H2B; Belongs to the histone H2B family. (113 aa)
ENSLCAP00010029519Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (91 aa)
ENSLCAP00010029533annotation not available (67 aa)
ENSLCAP00010029538CENP-T_C domain-containing protein. (82 aa)
ENSLCAP00010029546Histone domain-containing protein; Belongs to the histone H2B family. (54 aa)
ENSLCAP00010029552Uncharacterized protein; Belongs to the histone H2B family. (122 aa)
ENSLCAP00010029557Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (118 aa)
rnf169Uncharacterized protein. (596 aa)
LOC108889333MPN domain-containing protein. (260 aa)
ENSLCAP00010029805Proteasome 26S subunit, non-ATPase 11b. (439 aa)
LOC10889813114_3_3 domain-containing protein; Belongs to the 14-3-3 family. (252 aa)
ENSLCAP00010031434Proteasome subunit beta11b. (302 aa)
ENSLCAP00010031718DNA topoisomerase II binding protein 1. (1435 aa)
LOC108889618VWFA domain-containing protein. (375 aa)
LOC10889191814_3_3 domain-containing protein; Belongs to the 14-3-3 family. (258 aa)
kxd1KxDL domain-containing protein. (184 aa)
LOC108883136Proteasome subunit alpha type. (246 aa)
ENSLCAP00010032855RAD17 checkpoint clamp loader component. (467 aa)
psmc5AAA domain-containing protein; Belongs to the AAA ATPase family. (406 aa)
YWHAB14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (249 aa)
psmc2AAA domain-containing protein; Belongs to the AAA ATPase family. (433 aa)
BRCC3Lys-63-specific deubiquitinase BRCC36. (260 aa)
psme4Uncharacterized protein. (1847 aa)
ENSLCAP00010034255Exonuclease 1. (607 aa)
Rfc5AAA domain-containing protein. (350 aa)
ENSLCAP00010034591UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (167 aa)
LOC108890486UBIQUITIN_CONJUGAT_2 domain-containing protein. (202 aa)
Mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (666 aa)
psma2Proteasome subunit alpha type. (234 aa)
atripUncharacterized protein. (873 aa)
LOC10889391414_3_3 domain-containing protein; Belongs to the 14-3-3 family. (247 aa)
LOC108892908BTB domain-containing protein. (570 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (461 aa)
UbbUbiquitin B. (517 aa)
LOC108900816Histone H2A; Belongs to the histone H2A family. (138 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
rnf8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (523 aa)
LOC108873639Histone H2B; Belongs to the histone H2B family. (122 aa)
LOC10888438314_3_3 domain-containing protein; Belongs to the 14-3-3 family. (252 aa)
Cdca7lCell division cycle associated 7b. (416 aa)
ENSLCAP00010042963Histone H2B; Belongs to the histone H2B family. (175 aa)
ENSLCAP00010042987Histone H2B; Belongs to the histone H2B family. (111 aa)
ENSLCAP00010042999Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (145 aa)
LOC10887627414_3_3 domain-containing protein; Belongs to the 14-3-3 family. (251 aa)
rad50Zinc-hook domain-containing protein. (1313 aa)
ENSLCAP00010043392Rpn3_C domain-containing protein. (104 aa)
LOC108883136-2Proteasome subunit alpha type-6-like. (246 aa)
cdk2-2Cyclin-dependent kinase 2. (298 aa)
LOC108881898-2Proteasome subunit beta type-9. (216 aa)
LOC108881905Uncharacterized protein. (217 aa)
LOC108881903Proteasome subunit beta. (275 aa)
mcm5DNA helicase; Belongs to the MCM family. (737 aa)
Orc3Origin recognition complex, subunit 3. (712 aa)
mcm10Mcm10 domain-containing protein. (908 aa)
LOC108877696Proteasome subunit beta. (278 aa)
psmb2Proteasome subunit beta. (199 aa)
ENSLCAP00010046672Ubiquitin-like domain-containing protein. (116 aa)
psmb4Proteasome subunit beta; Belongs to the peptidase T1B family. (262 aa)
ENSLCAP00010046789Uncharacterized protein. (536 aa)
ENSLCAP00010046942Reverse transcriptase domain-containing protein. (1107 aa)
BreBRISC and BRCA1 A complex member 2. (383 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (729 aa)
Psma6Proteasome subunit alpha type. (204 aa)
LOC108888868VWFA domain-containing protein. (372 aa)
cdc7Protein kinase domain-containing protein. (610 aa)
ywhaq14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (257 aa)
rfc3AAA domain-containing protein. (356 aa)
ccnb1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (404 aa)
ENSLCAP00010049581Uncharacterized protein. (1795 aa)
ENSLCAP00010050470Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (209 aa)
ENSLCAP00010050501annotation not available (67 aa)
LOC108873640-3Histone H4. (103 aa)
LOC108878669ANK_REP_REGION domain-containing protein. (693 aa)
ENSLCAP00010051639Uncharacterized protein. (521 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (678 aa)
ankrd12ANK_REP_REGION domain-containing protein. (1957 aa)
ccnb3Uncharacterized protein; Belongs to the cyclin family. (431 aa)
PIEZO2Piezo-type mechanosensitive ion channel component. (2361 aa)
Psmd12Proteasome 26S subunit, non-ATPase 12. (456 aa)
ENSLCAP00010054492Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (91 aa)
ENSLCAP00010055640annotation not available (277 aa)
rfc4AAA domain-containing protein. (357 aa)
ENSLCAP00010055815Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (285 aa)
Cdca7Cell division cycle associated 7a. (391 aa)
Dna2DNA replication helicase/nuclease 2. (1408 aa)
Psmc3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (436 aa)
Psmb1Proteasome subunit beta. (243 aa)
psme2Uncharacterized protein. (341 aa)
psma3Proteasome subunit alpha type. (255 aa)
LOC108882499Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (573 aa)
rad9bUncharacterized protein. (328 aa)
Slf1SMC5-SMC6 complex localization factor 1. (752 aa)
ENSLCAP00010060028Proteasome activator subunit 3. (272 aa)
meiobUncharacterized protein. (460 aa)
psmd9PDZ domain-containing protein. (212 aa)
rmi1DUF1767 domain-containing protein. (700 aa)
Your Current Organism:
Lates calcarifer
NCBI taxonomy Id: 8187
Other names: Asian seabass, Holocentrus calcarifer, L. calcarifer, barramundi, barramundi perch
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