STRINGSTRING
Mdc1 Mdc1 CASP3 CASP3 LOC108877950 LOC108877950 ENSLCAP00010037861 ENSLCAP00010037861 Brca2 Brca2 Cdc25b Cdc25b ENSLCAP00010027048 ENSLCAP00010027048 e2f1 e2f1 foxm1 foxm1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Mdc1Uncharacterized protein. (2161 aa)
CASP3Caspase 3, apoptosis-related cysteine peptidase b; Belongs to the peptidase C14A family. (259 aa)
LOC108877950DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (768 aa)
ENSLCAP00010037861Caspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. (279 aa)
Brca2Breast cancer 2, early onset. (2872 aa)
Cdc25bRhodanese domain-containing protein. (385 aa)
ENSLCAP00010027048DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (314 aa)
e2f1E2F_TDP domain-containing protein. (454 aa)
foxm1Fork-head domain-containing protein. (678 aa)
Your Current Organism:
Lates calcarifer
NCBI taxonomy Id: 8187
Other names: Asian seabass, Holocentrus calcarifer, L. calcarifer, barramundi, barramundi perch
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