STRINGSTRING
ENSLCAP00010041597 ENSLCAP00010041597 wdhd1 wdhd1 dvl2 dvl2 sall1 sall1 Baz1b Baz1b ENSLCAP00010032855 ENSLCAP00010032855 ENSLCAP00010032564 ENSLCAP00010032564 ENSLCAP00010029530 ENSLCAP00010029530 ENSLCAP00010029507 ENSLCAP00010029507 braf braf Cdk1 Cdk1 ENSLCAP00010027354 ENSLCAP00010027354 ENSLCAP00010026403 ENSLCAP00010026403 ENSLCAP00010026315 ENSLCAP00010026315 zbtb18 zbtb18 top2a top2a rnaseh2b rnaseh2b ccne1 ccne1 fen1 fen1 LOC108879043 LOC108879043 ENSLCAP00010018787 ENSLCAP00010018787 ENSLCAP00010017630 ENSLCAP00010017630 LOC108882658 LOC108882658 LOC108879980 LOC108879980 Sirt1 Sirt1 uhrf1 uhrf1 ENSLCAP00010014063 ENSLCAP00010014063 cdk2 cdk2 Zbtb2 Zbtb2 Rcc1 Rcc1 cdk5 cdk5 hdac1 hdac1 dscc1 dscc1 pcna pcna lrwd1 lrwd1 Prmt6 Prmt6 cdc45 cdc45 LOC108884044 LOC108884044 Rnf168 Rnf168 jun jun smarcad1 smarcad1 cgnl1 cgnl1 pole pole LOC108887082 LOC108887082 Prim2 Prim2 LOC108872509 LOC108872509 ENSLCAP00010056833 ENSLCAP00010056833 rad18 rad18 apex1 apex1 ccna2 ccna2 chtf18 chtf18 dnmt1 dnmt1 Rnaseh2a Rnaseh2a sall4 sall4 Hdac3 Hdac3 pold2 pold2 Top2b Top2b ENSLCAP00010050497 ENSLCAP00010050497 HDAC2 HDAC2 hmces hmces LOC108897909 LOC108897909 LOC108877950 LOC108877950 Orc3 Orc3 LOC108892827 LOC108892827 cdk2-2 cdk2-2 smarca5 smarca5 prim1 prim1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSLCAP00010041597Histone H3; Belongs to the histone H3 family. (88 aa)
wdhd1Uncharacterized protein. (1130 aa)
dvl2Uncharacterized protein. (767 aa)
sall1Uncharacterized protein. (1306 aa)
Baz1bBromodomain adjacent to zinc finger domain, 1B. (1557 aa)
ENSLCAP00010032855RAD17 checkpoint clamp loader component. (467 aa)
ENSLCAP00010032564Alpha thalassemia/mental retardation syndrome X-linked homolog (human). (1999 aa)
ENSLCAP00010029530Histone H3; Belongs to the histone H3 family. (98 aa)
ENSLCAP00010029507Histone H3; Belongs to the histone H3 family. (125 aa)
brafUncharacterized protein. (856 aa)
Cdk1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (331 aa)
ENSLCAP00010027354Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (481 aa)
ENSLCAP00010026403Histone H3; Belongs to the histone H3 family. (107 aa)
ENSLCAP00010026315Histone H3; Belongs to the histone H3 family. (98 aa)
zbtb18Uncharacterized protein. (584 aa)
top2aDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1570 aa)
rnaseh2bUncharacterized protein. (306 aa)
ccne1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (433 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
LOC108879043Uncharacterized protein. (901 aa)
ENSLCAP00010018787Histone H3; Belongs to the histone H3 family. (117 aa)
ENSLCAP00010017630Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (327 aa)
LOC108882658Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1008 aa)
LOC108879980Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (380 aa)
Sirt1Deacetylase sirtuin-type domain-containing protein. (705 aa)
uhrf1Uncharacterized protein. (804 aa)
ENSLCAP00010014063Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (945 aa)
cdk2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (298 aa)
Zbtb2Uncharacterized protein. (103 aa)
Rcc1Regulator of chromosome condensation 1. (430 aa)
cdk5Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (292 aa)
hdac1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (482 aa)
dscc1Uncharacterized protein. (390 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
lrwd1WD_REPEATS_REGION domain-containing protein. (744 aa)
Prmt6Protein arginine methyltransferase 6; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (334 aa)
cdc45Uncharacterized protein. (568 aa)
LOC108884044Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (962 aa)
Rnf168Ring finger protein 168. (381 aa)
junBZIP domain-containing protein; Belongs to the bZIP family. (322 aa)
smarcad1Uncharacterized protein. (1071 aa)
cgnl1Uncharacterized protein. (1318 aa)
poleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2296 aa)
LOC108887082Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1112 aa)
Prim2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (502 aa)
LOC108872509Histone H3; Belongs to the histone H3 family. (136 aa)
ENSLCAP00010056833L3MBTL2, polycomb repressive complex 1 subunit. (615 aa)
rad18Uncharacterized protein. (505 aa)
apex1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (349 aa)
ccna2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (436 aa)
chtf18AAA domain-containing protein. (921 aa)
dnmt1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1511 aa)
Rnaseh2aRibonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (311 aa)
sall4Uncharacterized protein. (1088 aa)
Hdac3Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (459 aa)
pold2Uncharacterized protein. (471 aa)
Top2bDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1396 aa)
ENSLCAP00010050497Histone H3; Belongs to the histone H3 family. (90 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (507 aa)
hmcesAbasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (344 aa)
LOC108897909Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (436 aa)
LOC108877950DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (768 aa)
Orc3Origin recognition complex, subunit 3. (712 aa)
LOC108892827Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1098 aa)
cdk2-2Cyclin-dependent kinase 2. (298 aa)
smarca5Uncharacterized protein. (1056 aa)
prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (424 aa)
Your Current Organism:
Lates calcarifer
NCBI taxonomy Id: 8187
Other names: Asian seabass, Holocentrus calcarifer, L. calcarifer, barramundi, barramundi perch
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