STRINGSTRING
mcm5 mcm5 ccnc ccnc Med13 Med13 ENSLCAP00010031718 ENSLCAP00010031718 cdk8 cdk8 Sirt1 Sirt1 cdk2 cdk2 pcna pcna cdc45 cdc45 brca1 brca1 dbf4 dbf4 LOC108895376 LOC108895376 Cdt1 Cdt1 cdk2-2 cdk2-2 ccna2 ccna2 ccna1 ccna1 mcm10 mcm10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mcm5DNA helicase; Belongs to the MCM family. (737 aa)
ccncUncharacterized protein; Belongs to the cyclin family. (283 aa)
Med13Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (2171 aa)
ENSLCAP00010031718DNA topoisomerase II binding protein 1. (1435 aa)
cdk8Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (500 aa)
Sirt1Deacetylase sirtuin-type domain-containing protein. (705 aa)
cdk2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (298 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
cdc45Uncharacterized protein. (568 aa)
brca1Uncharacterized protein. (1411 aa)
dbf4Uncharacterized protein. (628 aa)
LOC108895376Med12 domain-containing protein. (2147 aa)
Cdt1Chromatin licensing and DNA replication factor 1. (482 aa)
cdk2-2Cyclin-dependent kinase 2. (298 aa)
ccna2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (436 aa)
ccna1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (416 aa)
mcm10Mcm10 domain-containing protein. (908 aa)
Your Current Organism:
Lates calcarifer
NCBI taxonomy Id: 8187
Other names: Asian seabass, Holocentrus calcarifer, L. calcarifer, barramundi, barramundi perch
Server load: low (14%) [HD]