17 items (Lates calcarifer) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	cdk8	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (500 aa)
	Sirt1	Deacetylase sirtuin-type domain-containing protein. (705 aa)
	cdk2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (298 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	cdc45	Uncharacterized protein. (568 aa)
	dbf4	Uncharacterized protein. (628 aa)
	brca1	Uncharacterized protein. (1411 aa)
	LOC108895376	Med12 domain-containing protein. (2147 aa)
	Cdt1	Chromatin licensing and DNA replication factor 1. (482 aa)
	ccna2	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (436 aa)
	ccna1	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (416 aa)
	mcm10	Mcm10 domain-containing protein. (908 aa)
	mcm5	DNA helicase; Belongs to the MCM family. (737 aa)
	cdk2-2	Cyclin-dependent kinase 2. (298 aa)
	ccnc	Uncharacterized protein; Belongs to the cyclin family. (283 aa)
	Med13	Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (2171 aa)
	ENSLCAP00010031718	DNA topoisomerase II binding protein 1. (1435 aa)

Your Current Organism:

Lates calcarifer

NCBI taxonomy Id: 8187
Other names: Asian seabass, Holocentrus calcarifer, L. calcarifer, barramundi, barramundi perch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cdt1	ENSLCAP00010031718	ENSLCAP00010000317	ENSLCAP00010031718	Chromatin licensing and DNA replication factor 1.	DNA topoisomerase II binding protein 1.	0.604
Cdt1	ccna1	ENSLCAP00010000317	ENSLCAP00010047573	Chromatin licensing and DNA replication factor 1.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.966
Cdt1	ccna2	ENSLCAP00010000317	ENSLCAP00010056469	Chromatin licensing and DNA replication factor 1.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.962
Cdt1	cdc45	ENSLCAP00010000317	ENSLCAP00010007031	Chromatin licensing and DNA replication factor 1.	Uncharacterized protein.	0.986
Cdt1	cdk2	ENSLCAP00010000317	ENSLCAP00010014041	Chromatin licensing and DNA replication factor 1.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.823
Cdt1	cdk2-2	ENSLCAP00010000317	ENSLCAP00010044385	Chromatin licensing and DNA replication factor 1.	Cyclin-dependent kinase 2.	0.823
Cdt1	dbf4	ENSLCAP00010000317	ENSLCAP00010003550	Chromatin licensing and DNA replication factor 1.	Uncharacterized protein.	0.914
Cdt1	mcm10	ENSLCAP00010000317	ENSLCAP00010046085	Chromatin licensing and DNA replication factor 1.	Mcm10 domain-containing protein.	0.997
Cdt1	mcm5	ENSLCAP00010000317	ENSLCAP00010045182	Chromatin licensing and DNA replication factor 1.	DNA helicase; Belongs to the MCM family.	0.999
Cdt1	pcna	ENSLCAP00010000317	ENSLCAP00010007860	Chromatin licensing and DNA replication factor 1.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.965
ENSLCAP00010031718	Cdt1	ENSLCAP00010031718	ENSLCAP00010000317	DNA topoisomerase II binding protein 1.	Chromatin licensing and DNA replication factor 1.	0.604
ENSLCAP00010031718	LOC108895376	ENSLCAP00010031718	ENSLCAP00010002633	DNA topoisomerase II binding protein 1.	Med12 domain-containing protein.	0.405
ENSLCAP00010031718	Med13	ENSLCAP00010031718	ENSLCAP00010035140	DNA topoisomerase II binding protein 1.	Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.405
ENSLCAP00010031718	brca1	ENSLCAP00010031718	ENSLCAP00010006276	DNA topoisomerase II binding protein 1.	Uncharacterized protein.	0.993
ENSLCAP00010031718	ccna1	ENSLCAP00010031718	ENSLCAP00010047573	DNA topoisomerase II binding protein 1.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.502
ENSLCAP00010031718	ccna2	ENSLCAP00010031718	ENSLCAP00010056469	DNA topoisomerase II binding protein 1.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.501
ENSLCAP00010031718	cdc45	ENSLCAP00010031718	ENSLCAP00010007031	DNA topoisomerase II binding protein 1.	Uncharacterized protein.	0.993
ENSLCAP00010031718	dbf4	ENSLCAP00010031718	ENSLCAP00010003550	DNA topoisomerase II binding protein 1.	Uncharacterized protein.	0.645
ENSLCAP00010031718	mcm10	ENSLCAP00010031718	ENSLCAP00010046085	DNA topoisomerase II binding protein 1.	Mcm10 domain-containing protein.	0.814
ENSLCAP00010031718	mcm5	ENSLCAP00010031718	ENSLCAP00010045182	DNA topoisomerase II binding protein 1.	DNA helicase; Belongs to the MCM family.	0.963