14 items (Lates calcarifer) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	rad18	Uncharacterized protein. (505 aa)
	usp19	Uncharacterized protein. (1574 aa)
	ENSLCAP00010053132	Ubiquitin carboxyl-terminal hydrolase. (763 aa)
	Ubr5	Ubiquitin protein ligase E3 component n-recognin 5. (2772 aa)
	cdk2-2	Cyclin-dependent kinase 2. (298 aa)
	rnf8	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (523 aa)
	trip12	Uncharacterized protein. (2062 aa)
	ENSLCAP00010031816	Granulin a. (787 aa)
	cdk2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (298 aa)
	e2f1	E2F_TDP domain-containing protein. (454 aa)
	atmin	C2H2-type domain-containing protein. (800 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	usp18	USP domain-containing protein; Belongs to the peptidase C19 family. (347 aa)
	Rnf168	Ring finger protein 168. (381 aa)

Your Current Organism:

Lates calcarifer

NCBI taxonomy Id: 8187
Other names: Asian seabass, Holocentrus calcarifer, L. calcarifer, barramundi, barramundi perch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSLCAP00010031816	Ubr5	ENSLCAP00010031816	ENSLCAP00010046631	Granulin a.	Ubiquitin protein ligase E3 component n-recognin 5.	0.478
ENSLCAP00010053132	Ubr5	ENSLCAP00010053132	ENSLCAP00010046631	Ubiquitin carboxyl-terminal hydrolase.	Ubiquitin protein ligase E3 component n-recognin 5.	0.480
ENSLCAP00010053132	pcna	ENSLCAP00010053132	ENSLCAP00010007860	Ubiquitin carboxyl-terminal hydrolase.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.845
ENSLCAP00010053132	rad18	ENSLCAP00010053132	ENSLCAP00010056799	Ubiquitin carboxyl-terminal hydrolase.	Uncharacterized protein.	0.819
ENSLCAP00010053132	rnf8	ENSLCAP00010053132	ENSLCAP00010041064	Ubiquitin carboxyl-terminal hydrolase.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.510
ENSLCAP00010053132	trip12	ENSLCAP00010053132	ENSLCAP00010036987	Ubiquitin carboxyl-terminal hydrolase.	Uncharacterized protein.	0.638
Rnf168	Ubr5	ENSLCAP00010005270	ENSLCAP00010046631	Ring finger protein 168.	Ubiquitin protein ligase E3 component n-recognin 5.	0.605
Rnf168	rad18	ENSLCAP00010005270	ENSLCAP00010056799	Ring finger protein 168.	Uncharacterized protein.	0.575
Rnf168	rnf8	ENSLCAP00010005270	ENSLCAP00010041064	Ring finger protein 168.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.882
Rnf168	trip12	ENSLCAP00010005270	ENSLCAP00010036987	Ring finger protein 168.	Uncharacterized protein.	0.695
Rnf168	usp18	ENSLCAP00010005270	ENSLCAP00010006772	Ring finger protein 168.	USP domain-containing protein; Belongs to the peptidase C19 family.	0.540
Ubr5	ENSLCAP00010031816	ENSLCAP00010046631	ENSLCAP00010031816	Ubiquitin protein ligase E3 component n-recognin 5.	Granulin a.	0.478
Ubr5	ENSLCAP00010053132	ENSLCAP00010046631	ENSLCAP00010053132	Ubiquitin protein ligase E3 component n-recognin 5.	Ubiquitin carboxyl-terminal hydrolase.	0.480
Ubr5	Rnf168	ENSLCAP00010046631	ENSLCAP00010005270	Ubiquitin protein ligase E3 component n-recognin 5.	Ring finger protein 168.	0.605
Ubr5	atmin	ENSLCAP00010046631	ENSLCAP00010007971	Ubiquitin protein ligase E3 component n-recognin 5.	C2H2-type domain-containing protein.	0.792
Ubr5	e2f1	ENSLCAP00010046631	ENSLCAP00010013681	Ubiquitin protein ligase E3 component n-recognin 5.	E2F_TDP domain-containing protein.	0.475
Ubr5	rad18	ENSLCAP00010046631	ENSLCAP00010056799	Ubiquitin protein ligase E3 component n-recognin 5.	Uncharacterized protein.	0.408
Ubr5	rnf8	ENSLCAP00010046631	ENSLCAP00010041064	Ubiquitin protein ligase E3 component n-recognin 5.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.487
Ubr5	trip12	ENSLCAP00010046631	ENSLCAP00010036987	Ubiquitin protein ligase E3 component n-recognin 5.	Uncharacterized protein.	0.999
Ubr5	usp18	ENSLCAP00010046631	ENSLCAP00010006772	Ubiquitin protein ligase E3 component n-recognin 5.	USP domain-containing protein; Belongs to the peptidase C19 family.	0.595