12 items (Lates calcarifer) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	wee1	Wee1-like protein kinase. (620 aa)
	Mtor	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2508 aa)
	LOC108895768	Uncharacterized protein. (356 aa)
	cdk2-2	Cyclin-dependent kinase 2. (298 aa)
	atrip	Uncharacterized protein. (873 aa)
	Cdk1	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (331 aa)
	mgmt	DNA_binding_1 domain-containing protein. (240 aa)
	idh1	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (428 aa)
	cdk2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (298 aa)
	Pdgfra	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1052 aa)
	atmin	C2H2-type domain-containing protein. (800 aa)
	egfr	Receptor protein-tyrosine kinase. (1196 aa)

Your Current Organism:

Lates calcarifer

NCBI taxonomy Id: 8187
Other names: Asian seabass, Holocentrus calcarifer, L. calcarifer, barramundi, barramundi perch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cdk1	atrip	ENSLCAP00010028139	ENSLCAP00010037873	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.485
Cdk1	wee1	ENSLCAP00010028139	ENSLCAP00010005543	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	Wee1-like protein kinase.	0.974
LOC108895768	Mtor	ENSLCAP00010047608	ENSLCAP00010004314	Uncharacterized protein.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.701
Mtor	LOC108895768	ENSLCAP00010004314	ENSLCAP00010047608	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein.	0.701
Pdgfra	atmin	ENSLCAP00010011522	ENSLCAP00010007971	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	C2H2-type domain-containing protein.	0.552
Pdgfra	egfr	ENSLCAP00010011522	ENSLCAP00010006148	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	Receptor protein-tyrosine kinase.	0.926
Pdgfra	idh1	ENSLCAP00010011522	ENSLCAP00010018731	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	0.400
Pdgfra	mgmt	ENSLCAP00010011522	ENSLCAP00010021697	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	DNA_binding_1 domain-containing protein.	0.432
atmin	Pdgfra	ENSLCAP00010007971	ENSLCAP00010011522	C2H2-type domain-containing protein.	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	0.552
atrip	Cdk1	ENSLCAP00010037873	ENSLCAP00010028139	Uncharacterized protein.	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	0.485
atrip	cdk2	ENSLCAP00010037873	ENSLCAP00010014041	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.413
atrip	cdk2-2	ENSLCAP00010037873	ENSLCAP00010044385	Uncharacterized protein.	Cyclin-dependent kinase 2.	0.413
cdk2	atrip	ENSLCAP00010014041	ENSLCAP00010037873	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.413
cdk2	wee1	ENSLCAP00010014041	ENSLCAP00010005543	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Wee1-like protein kinase.	0.827
cdk2-2	atrip	ENSLCAP00010044385	ENSLCAP00010037873	Cyclin-dependent kinase 2.	Uncharacterized protein.	0.413
cdk2-2	wee1	ENSLCAP00010044385	ENSLCAP00010005543	Cyclin-dependent kinase 2.	Wee1-like protein kinase.	0.827
egfr	Pdgfra	ENSLCAP00010006148	ENSLCAP00010011522	Receptor protein-tyrosine kinase.	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	0.926
egfr	mgmt	ENSLCAP00010006148	ENSLCAP00010021697	Receptor protein-tyrosine kinase.	DNA_binding_1 domain-containing protein.	0.427
idh1	Pdgfra	ENSLCAP00010018731	ENSLCAP00010011522	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	0.400
idh1	mgmt	ENSLCAP00010018731	ENSLCAP00010021697	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	DNA_binding_1 domain-containing protein.	0.793