18 items (Lates calcarifer) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC108882770	Uncharacterized protein. (691 aa)
	Mtor	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2508 aa)
	ccnd1	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (292 aa)
	LOC108890171	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (116 aa)
	cdc20	WD_REPEATS_REGION domain-containing protein. (502 aa)
	LOC108893384	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (115 aa)
	Cdk6	Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (313 aa)
	cdk2-2	Cyclin-dependent kinase 2. (298 aa)
	LOC108883763	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	cdk4	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (306 aa)
	ccna2	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (436 aa)
	LOC108893617	Uncharacterized protein. (765 aa)
	Cdk1	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (331 aa)
	LOC108900731	F-box domain-containing protein. (421 aa)
	LOC108890171-2	Insulin. (116 aa)
	cdk2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (298 aa)
	ENSLCAP00010013378	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (623 aa)
	ENSLCAP00010011972	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (62 aa)

Your Current Organism:

Lates calcarifer

NCBI taxonomy Id: 8187
Other names: Asian seabass, Holocentrus calcarifer, L. calcarifer, barramundi, barramundi perch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cdk1	LOC108900731	ENSLCAP00010028139	ENSLCAP00010024210	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	F-box domain-containing protein.	0.784
Cdk1	ccna2	ENSLCAP00010028139	ENSLCAP00010056469	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.992
Cdk1	ccnd1	ENSLCAP00010028139	ENSLCAP00010000381	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.726
Cdk1	cdc20	ENSLCAP00010028139	ENSLCAP00010028455	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	WD_REPEATS_REGION domain-containing protein.	0.826
Cdk6	LOC108900731	ENSLCAP00010041910	ENSLCAP00010024210	Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily.	F-box domain-containing protein.	0.784
Cdk6	ccna2	ENSLCAP00010041910	ENSLCAP00010056469	Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.892
Cdk6	ccnd1	ENSLCAP00010041910	ENSLCAP00010000381	Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.990
Cdk6	cdc20	ENSLCAP00010041910	ENSLCAP00010028455	Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily.	WD_REPEATS_REGION domain-containing protein.	0.739
Cdk6	cdk4	ENSLCAP00010041910	ENSLCAP00010044799	Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.909
ENSLCAP00010013378	ccnd1	ENSLCAP00010013378	ENSLCAP00010000381	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.579
LOC108882770	LOC108893617	ENSLCAP00010008657	ENSLCAP00010050141	Uncharacterized protein.	Uncharacterized protein.	0.902
LOC108882770	ccnd1	ENSLCAP00010008657	ENSLCAP00010000381	Uncharacterized protein.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.578
LOC108883763	Mtor	ENSLCAP00010052307	ENSLCAP00010004314	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.932
LOC108890171	LOC108893384	ENSLCAP00010000353	ENSLCAP00010038821	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.901
LOC108893384	LOC108890171	ENSLCAP00010038821	ENSLCAP00010000353	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.901
LOC108893617	LOC108882770	ENSLCAP00010050141	ENSLCAP00010008657	Uncharacterized protein.	Uncharacterized protein.	0.902
LOC108893617	ccnd1	ENSLCAP00010050141	ENSLCAP00010000381	Uncharacterized protein.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.553
LOC108900731	Cdk1	ENSLCAP00010024210	ENSLCAP00010028139	F-box domain-containing protein.	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	0.784
LOC108900731	Cdk6	ENSLCAP00010024210	ENSLCAP00010041910	F-box domain-containing protein.	Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily.	0.784
LOC108900731	ccna2	ENSLCAP00010024210	ENSLCAP00010056469	F-box domain-containing protein.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.959