41 items (Lates calcarifer) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC108872509	Histone H3; Belongs to the histone H3 family. (136 aa)
	ENSLCAP00010018787	Histone H3; Belongs to the histone H3 family. (117 aa)
	LOC108897230	Annexin. (544 aa)
	LOC108886019	Annexin. (369 aa)
	gapdh	Glyceraldehyde-3-phosphate dehydrogenase. (339 aa)
	mcm2	DNA helicase; Belongs to the MCM family. (916 aa)
	ewsr1	Uncharacterized protein. (603 aa)
	CASP3	Caspase 3, apoptosis-related cysteine peptidase b; Belongs to the peptidase C14A family. (259 aa)
	ENSLCAP00010026315	Histone H3; Belongs to the histone H3 family. (98 aa)
	Cdk9	Cyclin-dependent kinase 9 (CDC2-related kinase); Belongs to the protein kinase superfamily. (374 aa)
	ENSLCAP00010026403	Histone H3; Belongs to the histone H3 family. (107 aa)
	LOC108900018	Annexin. (326 aa)
	ENSLCAP00010029507	Histone H3; Belongs to the histone H3 family. (125 aa)
	ENSLCAP00010029530	Histone H3; Belongs to the histone H3 family. (98 aa)
	ENSLCAP00010037861	Caspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. (279 aa)
	Anxa10	Annexin. (348 aa)
	ENSLCAP00010041597	Histone H3; Belongs to the histone H3 family. (88 aa)
	ENSLCAP00010042315	Annexin. (509 aa)
	LOC108903146	Annexin. (315 aa)
	cdk2-2	Cyclin-dependent kinase 2. (298 aa)
	ccna1	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (416 aa)
	cdc7	Protein kinase domain-containing protein. (610 aa)
	ccnb1	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (404 aa)
	ENSLCAP00010049518	Annexin. (350 aa)
	ENSLCAP00010050497	Histone H3; Belongs to the histone H3 family. (90 aa)
	anxa1	Annexin. (372 aa)
	LOC108901497	Annexin. (321 aa)
	ccna2	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (436 aa)
	ENSLCAP00010057079	Es1 protein. (264 aa)
	Cdt1	Chromatin licensing and DNA replication factor 1. (482 aa)
	dbf4	Uncharacterized protein. (628 aa)
	LOC108883871	Annexin. (320 aa)
	wee1	Wee1-like protein kinase. (620 aa)
	LOC108879211	Annexin. (338 aa)
	Anxa4	Annexin. (342 aa)
	cdk2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (298 aa)
	anxa3	Annexin. (339 aa)
	LOC108894308	Annexin. (338 aa)
	LOC108879980	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (380 aa)
	fli1	Uncharacterized protein. (458 aa)
	anxa6	Annexin. (683 aa)

Your Current Organism:

Lates calcarifer

NCBI taxonomy Id: 8187
Other names: Asian seabass, Holocentrus calcarifer, L. calcarifer, barramundi, barramundi perch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP3	ENSLCAP00010037861	ENSLCAP00010058548	ENSLCAP00010037861	Caspase 3, apoptosis-related cysteine peptidase b; Belongs to the peptidase C14A family.	Caspase 3, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family.	0.902
CASP3	LOC108879980	ENSLCAP00010058548	ENSLCAP00010016052	Caspase 3, apoptosis-related cysteine peptidase b; Belongs to the peptidase C14A family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.523
CASP3	ccnb1	ENSLCAP00010058548	ENSLCAP00010049414	Caspase 3, apoptosis-related cysteine peptidase b; Belongs to the peptidase C14A family.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.575
Cdk9	LOC108879980	ENSLCAP00010025072	ENSLCAP00010016052	Cyclin-dependent kinase 9 (CDC2-related kinase); Belongs to the protein kinase superfamily.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.594
Cdk9	ccna1	ENSLCAP00010025072	ENSLCAP00010047573	Cyclin-dependent kinase 9 (CDC2-related kinase); Belongs to the protein kinase superfamily.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.445
Cdk9	ccna2	ENSLCAP00010025072	ENSLCAP00010056469	Cyclin-dependent kinase 9 (CDC2-related kinase); Belongs to the protein kinase superfamily.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.445
Cdk9	fli1	ENSLCAP00010025072	ENSLCAP00010016391	Cyclin-dependent kinase 9 (CDC2-related kinase); Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.486
Cdt1	ENSLCAP00010018787	ENSLCAP00010000317	ENSLCAP00010018787	Chromatin licensing and DNA replication factor 1.	Histone H3; Belongs to the histone H3 family.	0.528
Cdt1	ENSLCAP00010026315	ENSLCAP00010000317	ENSLCAP00010026315	Chromatin licensing and DNA replication factor 1.	Histone H3; Belongs to the histone H3 family.	0.528
Cdt1	ENSLCAP00010026403	ENSLCAP00010000317	ENSLCAP00010026403	Chromatin licensing and DNA replication factor 1.	Histone H3; Belongs to the histone H3 family.	0.528
Cdt1	ENSLCAP00010029507	ENSLCAP00010000317	ENSLCAP00010029507	Chromatin licensing and DNA replication factor 1.	Histone H3; Belongs to the histone H3 family.	0.528
Cdt1	ENSLCAP00010029530	ENSLCAP00010000317	ENSLCAP00010029530	Chromatin licensing and DNA replication factor 1.	Histone H3; Belongs to the histone H3 family.	0.521
Cdt1	ENSLCAP00010041597	ENSLCAP00010000317	ENSLCAP00010041597	Chromatin licensing and DNA replication factor 1.	Histone H3; Belongs to the histone H3 family.	0.528
Cdt1	ENSLCAP00010050497	ENSLCAP00010000317	ENSLCAP00010050497	Chromatin licensing and DNA replication factor 1.	Histone H3; Belongs to the histone H3 family.	0.528
Cdt1	LOC108872509	ENSLCAP00010000317	ENSLCAP00010057084	Chromatin licensing and DNA replication factor 1.	Histone H3; Belongs to the histone H3 family.	0.526
Cdt1	ccna1	ENSLCAP00010000317	ENSLCAP00010047573	Chromatin licensing and DNA replication factor 1.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.966
Cdt1	ccna2	ENSLCAP00010000317	ENSLCAP00010056469	Chromatin licensing and DNA replication factor 1.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.962
Cdt1	ccnb1	ENSLCAP00010000317	ENSLCAP00010049414	Chromatin licensing and DNA replication factor 1.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.491
Cdt1	cdc7	ENSLCAP00010000317	ENSLCAP00010048952	Chromatin licensing and DNA replication factor 1.	Protein kinase domain-containing protein.	0.931
Cdt1	cdk2	ENSLCAP00010000317	ENSLCAP00010014041	Chromatin licensing and DNA replication factor 1.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.823