(19 nodes) Breast cancer carboxy-terminal domain network (Lates calcarifer)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC108898738	DBF4-type domain-containing protein. (841 aa)
	brca1	Uncharacterized protein. (1411 aa)
	Poll	Polymerase (DNA directed), lambda; Belongs to the DNA polymerase type-X family. (601 aa)
	ENSLCAP00010008081	Tumor protein p53 binding protein, 1. (1495 aa)
	Mdc1	Uncharacterized protein. (2161 aa)
	ENSLCAP00010016365	DNA ligase. (967 aa)
	Paxip1	PAX interacting (with transcription-activation domain) protein 1. (1141 aa)
	parp1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
	Dntt	DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (532 aa)
	Rfc1	Replication factor C subunit 1. (1148 aa)
	mcph1	Uncharacterized protein. (835 aa)
	lig4	DNA ligase. (918 aa)
	dbf4	Uncharacterized protein. (628 aa)
	xrcc1	Uncharacterized protein. (627 aa)
	pes1	Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (586 aa)
	ect2	Uncharacterized protein. (1130 aa)
	LOC108880436	Uncharacterized protein. (814 aa)
	polm	DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (598 aa)
	ENSLCAP00010031718	DNA topoisomerase II binding protein 1. (1435 aa)

Your Current Organism:

Lates calcarifer

NCBI taxonomy Id: 8187
Other names: Asian seabass, Holocentrus calcarifer, L. calcarifer, barramundi, barramundi perch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Dntt	ENSLCAP00010016365	ENSLCAP00010021720	ENSLCAP00010016365	DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family.	DNA ligase.	0.708
Dntt	Poll	ENSLCAP00010021720	ENSLCAP00010007958	DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family.	Polymerase (DNA directed), lambda; Belongs to the DNA polymerase type-X family.	0.598
Dntt	lig4	ENSLCAP00010021720	ENSLCAP00010031670	DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family.	DNA ligase.	0.779
Dntt	parp1	ENSLCAP00010021720	ENSLCAP00010021233	DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.453
Dntt	xrcc1	ENSLCAP00010021720	ENSLCAP00010004235	DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family.	Uncharacterized protein.	0.867
ENSLCAP00010008081	ENSLCAP00010016365	ENSLCAP00010008081	ENSLCAP00010016365	Tumor protein p53 binding protein, 1.	DNA ligase.	0.579
ENSLCAP00010008081	ENSLCAP00010031718	ENSLCAP00010008081	ENSLCAP00010031718	Tumor protein p53 binding protein, 1.	DNA topoisomerase II binding protein 1.	0.993
ENSLCAP00010008081	LOC108880436	ENSLCAP00010008081	ENSLCAP00010043080	Tumor protein p53 binding protein, 1.	Uncharacterized protein.	0.877
ENSLCAP00010008081	Mdc1	ENSLCAP00010008081	ENSLCAP00010009212	Tumor protein p53 binding protein, 1.	Uncharacterized protein.	0.951
ENSLCAP00010008081	Paxip1	ENSLCAP00010008081	ENSLCAP00010016424	Tumor protein p53 binding protein, 1.	PAX interacting (with transcription-activation domain) protein 1.	0.951
ENSLCAP00010008081	brca1	ENSLCAP00010008081	ENSLCAP00010006276	Tumor protein p53 binding protein, 1.	Uncharacterized protein.	0.950
ENSLCAP00010008081	lig4	ENSLCAP00010008081	ENSLCAP00010031670	Tumor protein p53 binding protein, 1.	DNA ligase.	0.744
ENSLCAP00010008081	mcph1	ENSLCAP00010008081	ENSLCAP00010030336	Tumor protein p53 binding protein, 1.	Uncharacterized protein.	0.752
ENSLCAP00010008081	parp1	ENSLCAP00010008081	ENSLCAP00010021233	Tumor protein p53 binding protein, 1.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.552
ENSLCAP00010008081	xrcc1	ENSLCAP00010008081	ENSLCAP00010004235	Tumor protein p53 binding protein, 1.	Uncharacterized protein.	0.503
ENSLCAP00010016365	Dntt	ENSLCAP00010016365	ENSLCAP00010021720	DNA ligase.	DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family.	0.708
ENSLCAP00010016365	ENSLCAP00010008081	ENSLCAP00010016365	ENSLCAP00010008081	DNA ligase.	Tumor protein p53 binding protein, 1.	0.579
ENSLCAP00010016365	Poll	ENSLCAP00010016365	ENSLCAP00010007958	DNA ligase.	Polymerase (DNA directed), lambda; Belongs to the DNA polymerase type-X family.	0.866
ENSLCAP00010016365	Rfc1	ENSLCAP00010016365	ENSLCAP00010002331	DNA ligase.	Replication factor C subunit 1.	0.744
ENSLCAP00010016365	lig4	ENSLCAP00010016365	ENSLCAP00010031670	DNA ligase.	DNA ligase.	0.422