(38 nodes) Homologous recombination network (Lates calcarifer)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	nbn	FHA domain-containing protein. (868 aa)
	Pold1	DNA polymerase. (1098 aa)
	sycp3	Cor1 domain-containing protein. (261 aa)
	LOC108875967	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (606 aa)
	brca1	Uncharacterized protein. (1411 aa)
	Rbbp8	SAE2 domain-containing protein. (73 aa)
	ENSLCAP00010006675	Uncharacterized protein. (176 aa)
	pold3	Uncharacterized protein. (446 aa)
	brip1	Helicase ATP-binding domain-containing protein. (1549 aa)
	mus81	ERCC4 domain-containing protein. (622 aa)
	blm	Uncharacterized protein. (1413 aa)
	cdh17	Uncharacterized protein. (937 aa)
	rpa3	Uncharacterized protein. (122 aa)
	babam1	Uncharacterized protein. (377 aa)
	rad51d	RECA_2 domain-containing protein. (334 aa)
	rad54l	Uncharacterized protein. (740 aa)
	Fam175a	Abraxas 1, BRCA1 A complex subunit. (252 aa)
	Top3a	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1041 aa)
	rpa2	RPA_C domain-containing protein. (290 aa)
	rad51b	RECA_2 domain-containing protein. (386 aa)
	LOC108889333	MPN domain-containing protein. (260 aa)
	Brca2	Breast cancer 2, early onset. (2872 aa)
	rad52	Uncharacterized protein. (435 aa)
	XRCC2	X-ray repair cross complementing 2. (217 aa)
	Mre11	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (666 aa)
	Xrcc3	X-ray repair complementing defective repair in Chinese hamster cells 3. (342 aa)
	rad51c	RECA_2 domain-containing protein. (381 aa)
	sem1	Uncharacterized protein. (87 aa)
	LOC108880436	Uncharacterized protein. (814 aa)
	rad50	Zinc-hook domain-containing protein. (1313 aa)
	ENSLCAP00010046789	Uncharacterized protein. (536 aa)
	Bre	BRISC and BRCA1 A complex member 2. (383 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (678 aa)
	top3b	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (858 aa)
	pold2	Uncharacterized protein. (471 aa)
	pold4	Uncharacterized protein. (108 aa)
	eme1	ERCC4 domain-containing protein. (571 aa)
	ssbp1	Uncharacterized protein. (147 aa)

Your Current Organism:

Lates calcarifer

NCBI taxonomy Id: 8187
Other names: Asian seabass, Holocentrus calcarifer, L. calcarifer, barramundi, barramundi perch

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Brca2	Bre	ENSLCAP00010030231	ENSLCAP00010047145	Breast cancer 2, early onset.	BRISC and BRCA1 A complex member 2.	0.529
Brca2	ENSLCAP00010006675	ENSLCAP00010030231	ENSLCAP00010006675	Breast cancer 2, early onset.	Uncharacterized protein.	0.473
Brca2	LOC108875967	ENSLCAP00010030231	ENSLCAP00010003251	Breast cancer 2, early onset.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.621
Brca2	LOC108880436	ENSLCAP00010030231	ENSLCAP00010043080	Breast cancer 2, early onset.	Uncharacterized protein.	0.976
Brca2	LOC108889333	ENSLCAP00010030231	ENSLCAP00010029669	Breast cancer 2, early onset.	MPN domain-containing protein.	0.570
Brca2	Mre11	ENSLCAP00010030231	ENSLCAP00010035359	Breast cancer 2, early onset.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.885
Brca2	Pold1	ENSLCAP00010030231	ENSLCAP00010000489	Breast cancer 2, early onset.	DNA polymerase.	0.710
Brca2	RPA1	ENSLCAP00010030231	ENSLCAP00010051821	Breast cancer 2, early onset.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.621
Brca2	Rbbp8	ENSLCAP00010030231	ENSLCAP00010006577	Breast cancer 2, early onset.	SAE2 domain-containing protein.	0.862
Brca2	Top3a	ENSLCAP00010030231	ENSLCAP00010023203	Breast cancer 2, early onset.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.842
Brca2	XRCC2	ENSLCAP00010030231	ENSLCAP00010034447	Breast cancer 2, early onset.	X-ray repair cross complementing 2.	0.908
Brca2	Xrcc3	ENSLCAP00010030231	ENSLCAP00010037345	Breast cancer 2, early onset.	X-ray repair complementing defective repair in Chinese hamster cells 3.	0.978
Brca2	babam1	ENSLCAP00010030231	ENSLCAP00010015152	Breast cancer 2, early onset.	Uncharacterized protein.	0.407
Brca2	blm	ENSLCAP00010030231	ENSLCAP00010010683	Breast cancer 2, early onset.	Uncharacterized protein.	0.858
Brca2	brca1	ENSLCAP00010030231	ENSLCAP00010006276	Breast cancer 2, early onset.	Uncharacterized protein.	0.999
Brca2	brip1	ENSLCAP00010030231	ENSLCAP00010009245	Breast cancer 2, early onset.	Helicase ATP-binding domain-containing protein.	0.980
Brca2	cdh17	ENSLCAP00010030231	ENSLCAP00010011482	Breast cancer 2, early onset.	Uncharacterized protein.	0.409
Brca2	eme1	ENSLCAP00010030231	ENSLCAP00010055961	Breast cancer 2, early onset.	ERCC4 domain-containing protein.	0.658
Brca2	mus81	ENSLCAP00010030231	ENSLCAP00010010087	Breast cancer 2, early onset.	ERCC4 domain-containing protein.	0.743
Brca2	pold2	ENSLCAP00010030231	ENSLCAP00010053951	Breast cancer 2, early onset.	Uncharacterized protein.	0.418